| Project/Area Number |
22590323
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Human pathology
|
|---|
| Research Institution | Kanazawa Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TSUCHIYA Hiroyuki 金沢大学, 医学部, 教授 (40227434)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SHIMASAKI Miyako 金沢医科大学, 医学部, 助教 (00440511)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | アクアポリン / 骨肉腫 / 軟部肉腫 / 浸潤・転移 / 細胞移動 / 細胞増殖 / 遺伝子発 現修飾 / 自然肺転移実験動物モデル / 遺伝子導入 / 自然転移動物モデル / Aquaporin 1 / Aquaporin 5 / 細胞分化 / 移動・浸潤能 / 転移 / 偽細胞突起 / 免疫組織化学 / 細胞移動能 / 浸潤能 / HT1080 / トランスフェクション |
|---|
| Research Abstract |
Little is known on the molecular mechanism of invasion and metastasis of bone and soft tissue sarcomas. The present research addressing to the involvement of the novel functions of aquaporins revealed the expression of aquaporin1 and 5 and their prognostic significance in bone and soft tissue sarcomas. Furthermore, modification of aquaporin 1 and 5 gene expression in human bone and soft tissue sarcoma cell lines disclosed the functional roles of aquaporin 1 in the migration and invasion and aquaporin in cell proliferation in vitro, and involvement of aquaporin 1 in theinvasion and metastasis in vivo.
|
