| Project/Area Number |
22590325
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
IWAMOTO Takahiro 福岡大学, 医学部, 教授 (20300973)
TASHIRO Tadashi 福岡大学, 医学部, 教授 (20268981)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 急性大動脈解離 / 中膜平滑筋細胞 / Na+/Ca2+交換体 / 壁構成成分 / アポトーシス / 血行力学的因子 / Ｎａ＋／Ｃａ２＋交換体 / エラスチン / コラーゲン / プロテオグリカン / NCX1 / 壁力学特性 / mRNA / PT-PCR / 電子顕微鏡 / 単軸伸展試験 / 免疫組織化学染色 / 抗原賦活法 / 大動脈解離 / 嚢状中膜壊死 |
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| Research Abstract |
To clarify the mechanism of the aortic dissection, we investigated the protein and mRNA expression of sodium/calcium ion exchanger and the mechanical properties of the aortic wall of patients with aortic dissection (AD). The aortic wall of AD showed a significantly higher elasticity and decreased elastin fibers than that of normal control. This was associated with apoptosis of medial smoothmuscle cells, but not with the expression of sodium/calcium ion exchanger.
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