Epigenetic control of microRNA in the development gastric carcinomas in the elderly

• Project/Area Number: 22590329
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
• Principal Investigator: ARAI Tomio 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (20232019)
• Co-Investigator(Renkei-kenkyūsha): IZUMIYAMA Naotaka 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 助手 (10158751)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 胃癌 / 加齢 / microRNA / 高齢者 / マイクロサテライト不安定性 / 分化型癌 / 未分化型癌

Research Abstract

Gastric cancer is representative malignant neoplasm which increases with aging, and its carcinogenesis has been commonly studied based on the histological classification : differentiated type and undifferentiated type. However, gastric cancer often has histologic diversity within the tumor and it is difficult to explain a close relationship between histological classification and carcinogenesis. Therefore, we examined microsatellite instability (MSI) as a marker and found that MSI was significantly related with older age, occurrence in women, papillary adenocarcinoma and solid-type poorly differentiated adenocarcinoma. Unlike colorectal cancer, MSI was not associated with microRNA profile in gastric cancer. This may be due to variety of gastric cancer. Then, we focused on gastric poorly differentiated adenocarcinoma which often occurred in the elderly and found that microRNA profile in solid-type poorly cancer was different from that in nonsolid-type cancer. This result indicated that solid-type cancer may develop in the different way from nonsolid-type cancer.

Research Products

• [Journal Article] Frequent microsatellite instability in papillary and solid-type, poorly-differentiated adenocarcinomas of the stomach. (2013)
  • Author(s): Arai T, Sakurai U, Sawabe M, Honma N, Aijda J, Kanazawa N, Kuroiwa K, Takubo K.
  • Journal Title: Gastric Cancer Volume: (in press)
  • NAID: 40019845240
• [Journal Article] hTERT promoter polymorphism, -1327OT, is associated with the risk of epithelial cancer. (2013)
  • Author(s): Iizuka T, Sawabe M, Kaiyo Takubo K, Liu M, Homma Y, Suzui M, Arai T.
  • Journal Title: Springer Plus Volume: 2 Pages: 249-249
• [Journal Article] KRAS and BRAF mutations are rare and related to DNA mismatch repair deficiency in gastric cancer from the East and the West : Results from a large international multicentre study. (2013)
  • Author(s): van Grieken NCT, Aoyma T, Chambers PA, Bottomley D, Ward LC, Inam I, Buffart TE, Das K, Lim T, Pang B, Zhang SL, Tan IB, Carvalho B, Heideman DA, Miyagi Y, Kameda Y, AraiT, Meijer GA, Tsuburaya A, Tan P, Yoshikawa T, Grabsch HI.
  • Journal Title: Br J Cancer Volume: 108 Pages: 1495-501
• [Journal Article] Frequent microsatellite instability in papillary and solid-type, poorly-differentiated adenocarcinomas of the stomach (2013)
  • Author(s): Arai T, Sakurai U, Sawabe M, Honma N, Aijda J, Kanazawa N, Kuroiwa K, Takubo K
  • Journal Title: Gastric Cancer Volume: 16
  • NAID: 40019845240
  • Peer Reviewed
• [Journal Article] KRAS and BRAF mutations are rare and related to DNA mismatch repair deficiency in gastric cancer from the East and the West: Results from a large international multicentre study (2013)
  • Author(s): van Grieken NC, Aoyma T, Chambers PA, Bottomley D, Ward LC, et al.
  • Journal Title: Br J Cancer Volume: 108 Issue: 7 Pages: 1495-1501
  • DOI: 10.1038/bjc.2013.109
  • Peer Reviewed
• [Journal Article] Association between estrogen receptor-β dinucleotide repeat polymorphism and incidence of femoral fracture (2013)
  • Author(s): Honma N, Mori S, Zhou H, Ikeda S, Mieno MN, Tanaka N, Takubo K, Arai T,Sawabe M, Muramatsu M, Ito H
  • Journal Title: J Bone Miner Metab Volume: 31 Issue: 1 Pages: 96-101
  • DOI: 10.1007/s00774-012-0383-z
  • NAID: 10031168842
  • Peer Reviewed
• [Journal Article] Short telomeres in an oral precancerous lesion : Q-FISH analysis of leukoplakia (2012)
  • Author(s): Aida J, Kobayashi T, Saku T, Yamaguchi M, Shimomura N, Nakamura KI, Ishikawa N, Maruyama S, Cheng J, Poon SS, Sawabe M, aida T, Takubo K.
  • Journal Title: Journal of Oral Pathology & Medicine Volume: 41(5) Issue: 5 Pages: 372-378
  • DOI: 10.1111/j.1600-0714.2011.01120.x
  • Peer Reviewed
• [Journal Article] Chromosome 5q loss in colorectal flat adenomas (2012)
  • Author(s): Voorham QJM, Carvalho B, Spiertz AJ, van Grieken NCT, Mongera S, Rondagh EJA, et al.
  • Journal Title: Clin Cancer Res Volume: 18 Issue: 17 Pages: 4560-4569
  • DOI: 10.1158/1078-0432.ccr-11-2385
  • Peer Reviewed
• [Journal Article] Involvement of surfactant protein D in emphysema revealed by genetic association study (2012)
  • Author(s): Ishii T
  • Journal Title: Eur J Hum Genet Volume: 20(2) Issue: 2 Pages: 230-5
  • DOI: 10.1038/ejhg.2011.183
  • Peer Reviewed
• [Journal Article] A replication study examining three common single-nucleotide polymorphisms and the risk of prostate cancer in a Japanese population (2011)
  • Author(s): Liu M, Suzuki M, Arai T, Sawabe M, Enomoto Y, Nishimatsu H, Kume H, Homma Y, Kitamura T
  • Journal Title: Prostate Volume: 71 Issue: 10 Pages: 1023-1032
  • DOI: 10.1002/pros.21317
  • Peer Reviewed
• [Journal Article] Mitochondrial haplogroups A and M7a confer a genetic risk for coronary athrerosclerosis in the Japanese elderly : an autopsy study of 1,536 patients (2011)
  • Author(s): Sawabe M, Tanaka M, Chida K, Arai T, Nishigaki Y, Fuku N, Naka Mieno M, Kuchiba A, Tanaka N
  • Journal Title: J Athroscler Thromb Volume: 18 Pages: 166-175
  • Peer Reviewed
• [Journal Article] Alcoholics show reduced telomere length in the oesophagus (2011)
  • Author(s): Aida J, Yokoyama A, Izumiyama-Shimomura N, Nakamura K, Ishikawa N, Poon SSS, Fujiwara M, Sawabe M, Matsuura M, Arai T, Takubo K
  • Journal Title: J Pathol Volume: 223 Issue: 3 Pages: 410-416
  • DOI: 10.1002/path.2817
  • URL: http://www.thejournalofpathology.com
  • Peer Reviewed
• [Journal Article] Palisade vessels as a new histologic marker of esophageal origin in ER Specimens from columnar-lined esophagus (2011)
  • Author(s): Aida J, Vieth M, Ell C, May A, Pech O, Hoshihara Y, Kumagai Y, Kawada K, Hishima T, Tateishi Y, Sawabe M, Arai T, Matsuura M, Takubo K
  • Journal Title: Am J Surg Pathol Volume: 36 Issue: 8 Pages: 1140-1145
  • DOI: 10.1097/pas.0b013e3182206c0e
  • Peer Reviewed
• [Journal Article] Association between cancer risk and drug-metabolizing enzyme gene (CYP2A6, CYP2A13, CYP4B1, SULT1A1, GSTM1, and GSTT1) polymorphisms in cases of lung cancer in Japan (2011)
  • Author(s): Tamaki Y, Arai T, Sugimura H, Sasaki T, Honda M, Muroi Y, Matsubara Y, Kanno S, Ishikawa M, Hirasawa N, Hiratsuka M
  • Journal Title: Drug Metab Pharmacokinet Volume: 26 Pages: 516-522
  • NAID: 130004463215
  • Peer Reviewed
• [Journal Article] Novel single nucleotide polymorphism of the CYP2A13 gene in Japanese individuals (2011)
  • Author(s): Tamaki Y, Honda M, Muroi Y, Arai T, Sugimura H, Matsubara Y, Kanno S, Ishikawa M, Hirasawa N, Hiratsuka M
  • Journal Title: Drug Metab Pharmacokinet Volume: 26 Pages: 544-547
  • NAID: 130004463219
  • Peer Reviewed
• [Journal Article] Association of fucosyltransferase 8 (FUT8) polymorphism Thr267Lys with pulmonary emphysema (2011)
  • Author(s): Yamada M, Sawabe M, et al
  • Journal Title: Journal of human genetics Volume: 56 Issue: 12 Pages: 857-60
  • DOI: 10.1038/jhg.2011.118
  • NAID: 10030662015
  • Peer Reviewed
• [Journal Article] Association of rs6983561 polymorphism at 8q24 with prostate cancer mortality in a Japanese population (2011)
  • Author(s): Suzuki M, Liu M, Kurosaki T, Arai T, Sawabe M, Kasuya Y, Kato M, Fujimura T, Fukuhara H, Enomoto Y, Nishimatsu H, Ishikawa A, Kume H, Homma Y, Kitamura T
  • Journal Title: Clin Genitourin Cancer Volume: 9 Issue: 1 Pages: 46-52
  • DOI: 10.1016/j.clgc.2011.04.004
  • Peer Reviewed
• [Journal Article] Oestrogen receptor-beta CA repeat polymorphism is associated with incidence of colorectal cancer among females (2011)
  • Author(s): Honma N, et al
  • Journal Title: Histopathology Volume: 59 Issue: 2 Pages: 216-224
  • DOI: 10.1111/j.1365-2559.2011.03914.x
  • Peer Reviewed
• [Journal Article] Clinicopathologic characteristics of basaloid squamous carcinoma of the esophagus (2011)
  • Author(s): Arai T, Aida J, Nakamura K, Ushio Y, Takubo K
  • Journal Title: Esophagus Volume: 8 Issue: 3 Pages: 169-177
  • DOI: 10.1007/s10388-011-0280-x
  • Peer Reviewed
• [Journal Article] Telomere lengths in the oral epithelia with and withoutcarcmoma (2010)
  • Author(s): Aida J, Izumo T, Shimomura N, Nakamura K, Ishikawa N, Matsuura M, Poon SS, Fuijwara M, Sawabe M, Arai T, Takubo K
  • Journal Title: Eur J Cancer Volume: 46 Pages: 430-438
  • Peer Reviewed
• [Journal Article] Q-FISH analysis of telomere and chromosome instability in the oesophagus with and without squamous cell carcinoma in situ (2010)
  • Author(s): Takubo K, Fujita M, Izumiyama N, Nakamura K, Ishikawa N, Poon SS, Fujiwara M, Sawabe M, Matsuura M, Grabsch H, Arai T, Aida J
  • Journal Title: J Pathol Volume: 221 Pages: 201-209
  • Peer Reviewed
• [Journal Article] Polymorphism of SERPINE2 gene is associated with pulmonary emphysema in consecutive autopsy cases (2010)
  • Author(s): Fujimoto K, Ikeda S, Arai T, Tanaka N, Kumasaka T, Ishii T, Kida K, Muramatsu M, Sawabe M
  • Journal Title: BMC Med Genet Volume: 11 Pages: 159-159
  • Peer Reviewed
• [Journal Article] Changes of telomere length with aging (2010)
  • Author(s): Takubo K, Aida J, Izumiyama-Shimomura N, Ishikawa N, Sawabe M, Kurabayashi R, Shiraishi H, Arai T, Nakamura K
  • Journal Title: Geriatr Gerontol Int Volume: 10(Suppl 1)
  • NAID: 10027273944
  • Peer Reviewed
• [Journal Article] Role of methylation of the hMLHI gene promoter in the development of gastric and colorectal cazcinoma in the elderly (2010)
  • Author(s): Arai T
  • Journal Title: Geriatr Gerontol Int Volume: 10(Suppl 1)
  • Peer Reviewed
• [Journal Article] 髄様型大腸低分化腺癌の病理学的特徴 (2010)
  • Author(s): 新井冨生, 櫻井うらら, 沢辺元司, 金澤伸郎, 黒岩厚二郎, 潮靖子, 本間尚子, 相田順子, 田久保海誉
  • Journal Title: 胃と腸 Volume: 45 Pages: 1837-1846
• [Journal Article] 高齢者がんの臨床病理学的特徴 (2010)
  • Author(s): 新井冨生
  • Journal Title: 日本老年医学会雑誌 Volume: 47 Pages: 409-411
  • NAID: 10027914023
• [Journal Article] 大腸鋸歯状病変の病理診断 (2010)
  • Author(s): 新井冨生, 櫻井うらら, 沢辺元司, 本間尚子, 相田順子, 田久保海誉
  • Journal Title: 病理と臨床 Volume: 28 Pages: 613-618
• [Journal Article] 高齢者に対する胃癌治療の現況 (2010)
  • Author(s): 円谷彰, 林勉, 新井冨生, 浅香正博
  • Journal Title: 癌と化学療法 Volume: 37 Pages: 2817-2822
• [Presentation] 胃乳頭腺癌と充実型低分化腺癌は高頻度にマイクロサテライト不安定性を示す (2013)
  • Author(s): 新井冨生, 櫻井うらら, 本間尚子, 相田順子, 沢辺元司, 田久保海誉
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2013-06-06
• [Presentation] 高齢者胃癌におけるmicroRNA発現プロファイルとマイクロサテライト不安定性との関係 (2012)
  • Author(s): 新井冨生, 櫻井うらら, 沢辺元司, 本間尚子, 相田順子, 仲村賢一, 泉山七生貴, 田久保海誉
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-27
• [Presentation] Magnification endoscopic and histologic observations of palisade vessels at the esophagogastric junction, with reference to their nature and histologic utility (2012)
  • Author(s): Aida J, Tateishi Y, Vieth M, Kumagai Y, Arai T, Sawabe M, Fujiwara M, Hishima T, Nakamura K-I, Shimomura N, Ishikawa N, Takubo K
  • Organizer: 101^<st> Annual Meeting of the United States and Canadian Academy of Pathology
  • Place of Presentation: Vancouver (Canada)
  • Year and Date: 2012-03-20
• [Presentation] Telomere shortening in esophageal epithelium of alcoholics : differences in terms of ADH-1B and ALDH-2 genotypes and chromoendocscopy findings (2012)
  • Author(s): Aida J, Yokoyama A, Shimomura N, Nakamura K-I, Ishikawa N, Poon SSS, Fujiwara M, Sawabe M, Arai T, Takubo K
  • Organizer: 101^<st> Annual Meeting of the United States and Canadian Academy of Pathology
  • Place of Presentation: Vancouver (Canada)
  • Year and Date: 2012-03-19
• [Presentation] 老化と癌化に関連する遺伝子変化 (2012)
  • Author(s): 新井冨生
  • Organizer: 第13回関東甲信越地区遺伝子・染色体セミナー
  • Place of Presentation: 東京
  • Year and Date: 2012-02-05
• [Presentation] Clinicopathologic characteristics and molecular mechanisms of colorectal carcinomas in the elderly (2011)
  • Author(s): Arai T
  • Organizer: The 9^<th> Japan-Korea Gastrointestinal Seminar
  • Place of Presentation: Seoul (Korea)
  • Year and Date: 2011-12-09
• [Presentation] 肺癌ならびに喫煙とベンゾピレン代謝酵素,ドパミン・エストロゲン代謝酵素の遺伝子多型との関連 (2011)
  • Author(s): 新井冨生, 沢辺元司
  • Organizer: 第59回日本臨床検査医学会学術総会
  • Place of Presentation: 岡山
  • Year and Date: 2011-11-18
• [Presentation] 消化器内視鏡学会特別企画内視鏡医のための病理セッションBarrett食道の病理 (2011)
  • Author(s): 新井冨生
  • Organizer: 第82回日本消化器内視鏡学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2011-10-22
• [Presentation] Relationship between microRNA expression profile and microsatellite instability in gastric carcinomas in the elderly (高齢者胃癌におけるmicroRNA発現プロファイルとマイクロサテライト不安定性との関係) (2011)
  • Author(s): 新井冨生, 相田順子, 本間尚子, 下村七生貴, 仲村賢一, 田久保海誉
  • Organizer: 第70回日本癌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-05
• [Presentation] Relationship between microRNA expression profile and microsatellite instability in gastric carcinomas in the elderly(高齢者胃癌におけるmicroRNA発現プロファイルとマイクロサテライト不安定性との関係) (2011)
  • Author(s): 新井冨生, 相田順子, 本間尚子, 下村七生貴, 仲村賢一, 田久保海誉
  • Organizer: 第70回日本癌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-05
• [Presentation] 臓器別病理診断講習会(消化管),胃と大腸における充実型低分化腺癌の病理診断 (2011)
  • Author(s): 新井富生
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-04-30
• [Presentation] Frequent microsatellite instability and absent hMLHl expression in solid-type poorly differentiated adenocarcinoma of the stomach. (2011)
  • Author(s): Arai T, Sakurai U, Sawabe M, Honma N, Aida J, Takubo K.
  • Organizer: 9^<th> International Gastric Cancer Congress,
  • Place of Presentation: Seoul (Korea)
  • Year and Date: 2011-04-22
• [Presentation] Frequent microsatellite instability and absent hMLH1 expression in solid-type poorly differentiated adenocarcinoma of the stomach (2011)
  • Author(s): Arai T, Sakurai U, Sawabe M, Honma N, Aida J, Takubo K
  • Organizer: 9^<th> International Gastric Cancer Congress
  • Place of Presentation: Seoul (Korea)
  • Year and Date: 2011-04-22
• [Presentation] 高齢者胃癌・大腸癌の臨床病理学的特徴 (2011)
  • Author(s): 新井冨生
  • Organizer: 東海医学会
  • Place of Presentation: 伊勢原
  • Year and Date: 2011-04-12
• [Presentation] 髄様型低分化大腸癌の発生経路と組織発生に関する病理学的検討 (2011)
  • Author(s): 新井冨生, 櫻井うらら, 沢辺元司, 金澤伸郎, 黒岩厚二郎, 潮靖子, 本間尚子, 相田順子, 田久保海誉
  • Organizer: 第74回大腸癌研究会
  • Place of Presentation: 福岡
  • Year and Date: 2011-01-21
• [Presentation] 高齢者胃癌・大腸癌の臨床病理学的特徴 (2010)
  • Author(s): 新井冨生
  • Organizer: 第346回浜松消化器病研究会
  • Place of Presentation: 浜松
  • Year and Date: 2010-11-04
• [Presentation] 教育シンポジウム「高齢者腫瘍学(Geriatric Oncology):高齢者の特性とがん医療」高齢者がんの特性 (2010)
  • Author(s): 新井冨生
  • Organizer: 第48回日本癌治療学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2010-10-29
• [Presentation] Q-FISH analysis of telomere and chromosome instability in the esophagus with and without squamous cell carcinoma in situ (2010)
  • Author(s): Aida J, Fujita M, Shimomura N, Nakamura K, Arai T, Takubo K
  • Organizer: 12^<th> World Congress of the International Society for Diseases of the Esophagus
  • Place of Presentation: Kagoshima, Japan
  • Year and Date: 2010-09-03
• [Presentation] SLC22A 3-LPAL2-LPA領域のハプロタイプ,血清Lipoprotein(a)値冠動脈硬化症,冠動脈疾患のパス解析結果 (2010)
  • Author(s): 沢辺元司, 濱松晶彦, 千田宏司, 新井冨生, 原田和昌, 稲松孝思, 小澤利男, 中原賢一, 松下哲
  • Organizer: 第52回日本老年医学会学術集会・総会
  • Place of Presentation: 神戸
  • Year and Date: 2010-06-26
• [Presentation] Meet the Expert(教育企画)高齢者診療のポイント.高齢者がんの臨床病理学的特徴 (2010)
  • Author(s): 新井冨生
  • Organizer: 第52回日本老年医学会学術集会・総会
  • Place of Presentation: 神戸
  • Year and Date: 2010-06-25
• [Presentation] 病理解剖試料に由来する組織バンク(病理解剖バイオバンク)事業の開始 (2010)
  • Author(s): 沢辺元司, 新井冨生, 櫻井うらら, 本間尚子, 相田順子, 田久保海誉, 初田裕幸, 足立正, 村山繁雄
  • Organizer: 第52回日本老年医学会学術集会・総会
  • Place of Presentation: 神戸
  • Year and Date: 2010-06-25
• [Presentation] 正角化型口腔異型上皮における構成細胞のテロメア長と染色体不安定性についてQ-FISH法による解析 (2010)
  • Author(s): 相田順子, 小林孝憲, 丸山智, 程〓, 朔敬, 泉山七生貴, 仲村賢一, 石川直, 玉橋うらら, 沢辺元司, 新井冨生, 田久保海誉
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-29
• [Presentation] Estrogen receptor-β CA repeat遺伝子多型と大腸癌発症率との関係 (2010)
  • Author(s): 本間尚子, 新井冨生, 玉橋うらら, 田久保海誉, 沢辺元司
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-28
• [Presentation] SLC22A3-LPAL2-LPA領域の遺伝子多型は血清Lipoprotein(a)値,冠動脈疾患,脳血管疾患と有意な関連を示す (2010)
  • Author(s): 沢辺元司, 濱松晶彦, 玉橋うらら, 新井冨生, 相田順子, 本間尚子, 村山繁雄, 田久保海誉
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-28
• [Presentation] マイクロサテライト不安定性を示す大腸癌の臨床病理学的特徴 (2010)
  • Author(s): 新井富生, 玉橋うらら, 沢辺元司, 本間尚子, 相田順子, 田久保海誉
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-27
• [Presentation] Clostridium perfringensによる壊死性腸炎の-剖検例-虚血性腸疾患との鑑別- (2010)
  • Author(s): 玉橋うらら, 新井冨生, 沢辺元司, 本間尚子, 相田順子, 田久保海誉
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-27
• [Presentation] Modern management of gastrointestinal tract: oesophageal dysplasia
  • Author(s): Arai T
  • Organizer: XXIX Congress of the International Academy of Pathology
  • Place of Presentation: Cape Town (South Africa)
  • Invited
• [Presentation] 高齢者胃癌におけるmicroRNA発現プロファイルとマイクロサテライト不安定性との関係
  • Author(s): 新井冨生，櫻井うらら，沢辺元司，本間尚子，相田順子，仲村賢一，泉山七生貴，田久保海誉
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 東京
• [Book] 田久保海誉，大橋健一編「腫瘍病理鑑別診断アトラス 食道癌」第２部 組織型と診断の実際．VI．非上皮性腫瘍，腫瘍様病変の項目（11ページ）を執筆 (2012)
  • Author(s): 新井冨生
  • Total Pages: 222
  • Publisher: 文光堂
• [Book] 青笹克之，八尾隆史編「癌診療指針のための病理診断プラクティス 大腸癌」『大腸上皮性腫瘍および腫瘍様病変の分類とその意義』の項目（12ページ）を執筆 (2012)
  • Author(s): 新井冨生
  • Total Pages: 271
  • Publisher: 中山書店
• [Book] 「癌診療指針のための病理診断プラクティス食道癌・胃癌」『組織像からみた悪性度診断』の項目を執筆(青笹克之、藤盛孝博編) (2012)
  • Author(s): 新井冨生, 相田順子, 田久保海誉
  • Total Pages: 8
  • Publisher: 中山書店
• [Book] 腫瘍病理鑑別診断アトラス大腸癌(『低分化腺癌,印環細胞癌,粘液癌』の3項目を執筆 (2011)
  • Author(s): 新井冨生
  • Total Pages: 22
  • Publisher: 文光堂
• [Book] 第11章老化を執筆(シンプル病理学改訂第6版)(笹野公伸, 岡田保典, 安井弥編) (2010)
  • Author(s): 新井冨生
  • Total Pages: 360
  • Publisher: 南江堂
• [Remarks]
  • URL: http://www.ttaggg-rtgp.org/
• [Remarks] 高齢者がん研究グループホームページ
  • URL: http://www.ttaggg-rtgp.org/
• [Remarks]
  • URL: http://www.ttaggg-rtgp.org/
• [Remarks]
  • URL: http://www.ttaggg-rtgp.org/