| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
We studied the mechanisms which Cthrc1, identified as a coupling factor by us, is transcriptionally regulated by osteoclastic bone resorption. We found that Cthrc1 is transcriptionally expressed in osteoclasts in the presence of high concentration of minerals, such as calcium and phosphate, which are released from bone matrices by osteoclastic bone resorption. Screening of a chemical library, we found 12 compounds which stimulate Cthrc1 transcription by using its promoter in vitro and identified one compound that induces Cthrc1 expression in bone when injected to mice. These results suggest that such compound will be a candidate of leading drug for osteoporotic patients.
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