| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Research Abstract |
Hepatocyte nuclear factor-4α (HNF4α) is a member of the nuclear receptor superfamily involved in endodermal development and hepatocyte differentiation. The expression of HNF4α isoforms is specific to the cell type in normal tissues. Using antibodies recognizing P1- and P2-isoforms, we investigate pulmonary adenocarcinoma and hepatocellular carcinoma. Thyroid transcription factor-1 (TTF-1) is highly expressed in a large proportion of pulmonary adenocarcinoma; however, most TTF-1-negative pulmonary adenocarcinomas were mucinous lesions with the predominant expressions of HNF4α. The higher expression of P2-isoform was observed in low histological grading of hepatocelluar carcinomas and was regarded as an index to predict poor prognosis of the patients.
|
