| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
The aim of this study is to elucidate the pathomechaism of clearance of deposited amyloid fibrils in patients with familial amyloid polyneuropathy (FAP) with having undergone liver transplantation. On investigation of deposited amyloid fibrils in the gastric mucosa in FAP patients who had undergone liver transplantation, the amount of deposited amyloid was not markedly different between before and after liver transplantation. However, the composition ratio of the wild-type transthyretin (TTR) in deposited amyloid significantly increased. Our results suggest that the deposition of wild-type TTR and clearance of amyloid fibrils composed with variant and wild-type TTR (amyloid turnover) always occur in every organ in post -transplant stage of FAP patients.
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