A study of the pathomechanism of amyloid fibril turnover in FAP patients after liver transplantation
Project/Area Number |
22590332
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Human pathology
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Research Institution | Shinshu University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
IKEDA Shu-ichi 信州大学, 医学部, 教授 (60135134)
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Research Collaborator |
SEKIJIMA Yoshiki 信州大学, 医学部附属病院, 准教授 (60322715)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 分子病理 / アミロイドーシス / トランスサイレチン / 家族性アミロイドポリニューロパチー / アミロイド線維融解 / amyloid turn-over / amyloid regression |
Research Abstract |
The aim of this study is to elucidate the pathomechaism of clearance of deposited amyloid fibrils in patients with familial amyloid polyneuropathy (FAP) with having undergone liver transplantation. On investigation of deposited amyloid fibrils in the gastric mucosa in FAP patients who had undergone liver transplantation, the amount of deposited amyloid was not markedly different between before and after liver transplantation. However, the composition ratio of the wild-type transthyretin (TTR) in deposited amyloid significantly increased. Our results suggest that the deposition of wild-type TTR and clearance of amyloid fibrils composed with variant and wild-type TTR (amyloid turnover) always occur in every organ in post -transplant stage of FAP patients.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] First two cases of adult-onset type II citrullinemia successfully treated by deceased-donor liver transplantation in Japan.2012
Author(s)
Yazaki M, Hineno A, Matsushima A, Ozawa K, Kishida D, Tazawa K, Fukushima K, Urata K, Ikegami T, Miyagawa S, Ikeda S.
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Journal Title
Hepatol Res
Volume: 42
Issue: 9
Pages: 934-939
DOI
Related Report
Peer Reviewed
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