| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
Genomic region, which is frequently lost in the process of malignant transformation of pancreatic precancerous lesions was clarified. Furthermore, the responsible gene located on this region was identified. This gene was shown to function as a tumor suppressor gene in pancreatic cancer by the finding that the introduction of this gene into pancreatic cancer cells had induced their cell cycle arrest followed by the decreased proliferation. It is expected in future that this gene and the related molecules can become a new diagnostic and therapeutic target of the pancreatic cancer .
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