Identification of the responsible genes on 8p involved in themalignant transformation of the precancerous lesions in the pancreas .

• Project/Area Number: 22590335
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Oita University
• Principal Investigator: HIJIYA Naoki 大分大学, 医学部, 助教 (80305036)
• Co-Investigator(Kenkyū-buntansha): MORIYAMA Masatsugu 大分大学, 医学部, 教授 (90239707)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 膵癌 / がん抑制遺伝子 / 増殖 / 癌抑制遺伝子 / 分子標的剤 / 細胞株 / アレイCGH / 網羅的発現解析

Research Abstract

Genomic region, which is frequently lost in the process of malignant transformation of pancreatic precancerous lesions was clarified. Furthermore, the responsible gene located on this region was identified. This gene was shown to function as a tumor suppressor gene in pancreatic cancer by the finding that the introduction of this gene into pancreatic cancer cells had induced their cell cycle arrest followed by the decreased proliferation. It is expected in future that this gene and the related molecules can become a new diagnostic and therapeutic target of the pancreatic cancer .

Research Products

• [Journal Article] Genomic profiling of oral squamous cell carcinomaby array-based comparative genomic hybridization (2013)
  • Author(s): Yoshioka S, Tsukamoto Y, Hijiya N, Nakada C, Uchida T, Matsuura K, Takeuchi I, Seto M, Kawano K, Moriyama M
  • Journal Title: PLoS One Volume: 8(2) Issue: 2 Pages: 56165-56165
  • DOI: 10.1371/journal.pone.0056165
  • Peer Reviewed
• [Journal Article] MiR-29c is downregulated in gastric carcinomas and regulates cell proliferation by targeting RCC2 (2013)
  • Author(s): Matsuo M, Nakada C, Tsukamoto Y, Noguchi T, Uchida T, Hijiya N, Matsuura K, Moriyama M
  • Journal Title: Mol Cancer Volume: 12(1) Pages: 15-15
  • Peer Reviewed
• [Journal Article] MiR-29c is downregulated in gastric carcinomas and regulates cell proliferation by targeting RCC2 (2013)
  • Author(s): Matsuo M, Nakada C, Tsukamoto Y, Noguchi T, Uchida T, Hijiya N, Matsuura K, Moriyama M.
  • Journal Title: Mol Cancer Volume: 12 Pages: 15-15
  • Peer Reviewed
• [Journal Article] Extrahepatic bile duct cancer: invasion of the posterior hepatic plexuses--evaluation using multidetector CT (2012)
  • Author(s): Yamada Y, Mori H, Hijiya N, Matsumoto S, Takaji R, Kiyonaga M, Ohta M, Kitano S, Moriyama M, Takaki H, Fukuzawa K, Yonemasu H
  • Journal Title: Radiology Volume: 263(2) Issue: 2 Pages: 419-28
  • DOI: 10.1148/radiol.12111024
  • Peer Reviewed
• [Journal Article] Genomic profiling of renal cell carcinoma in patients with end-stage renal disease (2012)
  • Author(s): Inoue T, et al
  • Journal Title: Cancer science Volume: 103 Issue: 3 Pages: 569-576
  • DOI: 10.1111/j.1349-7006.2011.02176.x
  • Peer Reviewed
• [Journal Article] Peripancreatic strandsappearance in pancreatic body and tail carcinoma: evaluation by multi-detector CT with pathological correlation (2012)
  • Author(s): Matsumoto S, Mori H, Kiyonaga M, SaiM, Yamada Y, Hijiya N, Shibata K, OhtaM, Kitano S, Takaki H, Fukuzawa K, Yonemasu H
  • Journal Title: Abdom Imaging Volume: 37(4) Issue: 4 Pages: 602-8
  • DOI: 10.1007/s00261-011-9803-0
  • Peer Reviewed
• [Journal Article] Intraductal papillary mucinous neoplasms of the pancreas complicated with intraductal hemorrhage,perforation, and fistula formation: CT and MR imaging findings with pathologic correlation (2012)
  • Author(s): Yamada Y, Mori H, Hijiya N, Matsumoto S, Takaji R, Ohta M, Kitano S, Moriyama M
  • Journal Title: Abdom Imaging Volume: 37(1) Issue: 1 Pages: 100-9
  • DOI: 10.1007/s00261-011-9723-z
  • Peer Reviewed
• [Journal Article] Downregulation of sav1 plays a role in pathogenesis of high-grade clear cell renal cell carcinoma (2011)
  • Author(s): Matsuura K, et al
  • Journal Title: BMC cancer Volume: 11 Issue: 1 Pages: 523-523
  • DOI: 10.1186/1471-2407-11-523
  • Peer Reviewed
• [Journal Article] Genomic profiling of submucosal-invasive gastric cancer by array-based comparative genomic hybridization (2011)
  • Author(s): Kuroda-Akiko, et al
  • Journal Title: PLoS One Volume: 6(7) Issue: 7 Pages: 22313-22313
  • DOI: 10.1371/journal.pone.0022313
  • Peer Reviewed
• [Journal Article] Overexpression of miR-210, a downstream target of HIF1α, causes centrosome amplification in renal carcinoma cells (2011)
  • Author(s): Nakada C, et al
  • Journal Title: J Pathol Volume: 224 Issue: 2 Pages: 280-8
  • DOI: 10.1002/path.2860
  • Peer Reviewed
• [Journal Article] Visinin-like protein-1 overexpression is an indicator of lymph node metastasis and poor prognosis in colorectal cancer patients (2011)
  • Author(s): Akagi T, et al
  • Journal Title: Int J Cancer Volume: (published on line) Issue: 6 Pages: 1307-1317
  • DOI: 10.1002/ijc.27341
  • Peer Reviewed
• [Journal Article] Induction of GNE in myofibers after muscle injury (2010)
  • Author(s): Nakamura K, Tsukamoto Y, Hijiya N, Higuchi Y, Yano S, Yokoyama S, Kumamoto T, Moriyama M
  • Journal Title: Pathobiology Volume: 77(4) Issue: 4 Pages: 191-9
  • DOI: 10.1159/000292652
  • Peer Reviewed
• [Journal Article] Genomic profiling of gastric carcinoma in situ and adenomas by array-based comparative genomichybridization (2010)
  • Author(s): Uchida M, Tsukamoto Y, Uchida T,Ishikawa Y, Nagai T, Hijiya N, Nguyen LT, Nakada C, Kuroda A, Okimoto T, Kodama M, Murakami K, Noguchi T, Matsuura K, Tanigawa M, Seto M, Ito H, Fujioka T, Takeuchi I, Moriyama M
  • Journal Title: J Pathol Volume: 221(1) Issue: 1 Pages: 96-105
  • DOI: 10.1002/path.2686
  • Peer Reviewed
• [Journal Article] Genomic profiling of gastric carcinoma in situ and adenomas by array-based comparative genomic hybridization. (2010)
  • Author(s): Uchida M
  • Journal Title: Journal of Pathology Volume: 221 Pages: 96-105
  • Peer Reviewed
• [Journal Article] Induction of GNE in myofibers after muscle injury. (2010)
  • Author(s): Nakamura K
  • Journal Title: Pathobiology Volume: 77 Pages: 191-199
  • Peer Reviewed
• [Journal Article] Invasive carcinomas originating from intraductal papillary mucinous neoplasms of the pancreas : conspicuity and primary sites of the solid masses on triple-phase dynamic CT imaging. (2010)
  • Author(s): Yamada Y
  • Journal Title: Abdominal Imaging Volume: 35 Pages: 181-188
  • Peer Reviewed
• [Presentation] 破裂による腹膜炎で発見された膵粘液性嚢胞腫瘍の 1 例 (2012)
  • Author(s): 清永 麻紀, 森 宣, 松本俊郎, 山田 康成, 高司 亮, 泥谷 直樹, 守山 正胤
  • Organizer: 第48回日本医学放射線学会秋季臨床大会
  • Place of Presentation: 長崎
• [Presentation] Primary hepatic neuroendocrine carcinoma の 1 例 (2012)
  • Author(s): 高司 亮, 山田 康成, 松本 俊郎, 本郷哲央, 首藤 利英子, 清永 麻紀, 森 宣, 岩下 幸雄, 太田 正之, 北野 正剛, 泥谷 直樹, 守山 正胤
  • Organizer: 第48回日本医学放射線学会秋季臨床大会
  • Place of Presentation: 長崎
• [Presentation] 腎淡明細胞癌におけるmiR-210 の過剰発現の意義 (2012)
  • Author(s): 中田 知里, 塚本 善之, 松浦 恵子, グエン・トゥン・ラム , 泥谷 直樹, 内田智久, 佐藤 文憲, 三股 浩光, 瀬戸 加大, 守山 正胤
  • Organizer: 第70回日本癌学会総会
  • Place of Presentation: 札幌
• [Presentation] 腎淡明細胞癌転移予測因子としての9p24.1-p13.3 loss の可能性 (2012)
  • Author(s): 成松 隆弘, 松浦 恵子, 泥谷 直樹, 中田 知里, 井上 享, 野村 威雄, 佐藤文憲, 瀬戸 加大, 三股 浩光, 守山 正胤
  • Organizer: 第70回日本癌学会総会
  • Place of Presentation: 札幌
• [Presentation] MDCT による肝外胆管癌の Posterior hepatic plexuses への浸潤評価 (2012)
  • Author(s): 清永 麻紀, 森 宣, 山田 康成, 松本俊郎, 高司 亮, 泥谷 直樹, 守山 正胤
  • Organizer: 第71回日本医学放射線学会学術集会
  • Place of Presentation: 横浜
• [Presentation] 網羅的ゲノム解析による腎癌転移関連遺伝子の同定と解析 (2012)
  • Author(s): 成松 隆弘, 松浦 恵子, 泥谷 直樹, 中田 知里, 井上 享, 野村 威雄, 竹内一郎, 瀬戸 加大, 佐藤 文憲, 守山 正胤, 三股 浩光
  • Organizer: 第100回日本泌尿器科学会
  • Place of Presentation: 横浜
• [Presentation] 破裂による腹膜炎で発見された膵粘液性嚢胞腫瘍の1例 (2012)
  • Author(s): 清永 麻紀, 森 宣, 松本 俊郎, 山田 康成, 高司 亮, 泥谷 直樹, 守山 正胤
  • Organizer: 日本医学放射線学会秋季臨床大会
  • Place of Presentation: 長崎
• [Presentation] Primary hepatic neuroendocrine carcinomaの1例 (2012)
  • Author(s): 高司 亮, 山田 康成, 松本 俊郎, 本郷 哲央, 首藤 利英子, 清永 麻紀, 森 宣, 岩下 幸雄, 太田 正之, 北野 正剛, 泥谷 直樹, 守山 正胤
  • Organizer: 日本医学放射線学会秋季臨床大会
  • Place of Presentation: 長崎
• [Presentation] 大腸癌のリンパ節転移に関与する責任遺伝子の同定と機能解析 (2011)
  • Author(s): 赤木智徳, 猪股雅史, 衛藤剛, 安田一弘, 白石憲男, 泥谷直樹, 守山正胤, 北野正剛
  • Organizer: 第III回日本外科学会定期学術集会
  • Place of Presentation: (震災のため紙上開催)(日本外科学会雑誌第112巻臨時増刊号(1・2)抄録集)
  • Year and Date: 2011-05-25
• [Presentation] 多発膵管状腺癌の1例 (2010)
  • Author(s): 高司亮, 山田康成, 松本俊郎, 本郷哲央, 森宣, 太田正之, 北野正剛, 泥谷直樹, 守山正胤
  • Organizer: 日本医学放射線学会秋季臨床大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2010-09-18
• [Presentation] 血管内リンパ腫 2 剖検例の臨床病理学的検討 (2010)
  • Author(s): 中村 憲一郎, 内田 智久, 木村 成志, 岡崎 敏郎, 迫 祐介, 荒川 竜樹, 泥谷直樹, 守山 正胤, 熊本 俊秀
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京
• [Presentation] 多発膵管状腺癌の 1 例 (2010)
  • Author(s): 高司 亮, 山田 康成, 松本 俊郎, 本郷哲央, 森 宣, 太田 正之, 北野 正剛, 泥谷 直樹, 守山 正胤
  • Organizer: 第46回日本医学放射線学会秋季臨床大会
  • Place of Presentation: 横浜
• [Presentation] 大腸癌のリンパ節転移に関与する責任遺伝子の同定と機能解析
  • Author(s): 赤木 智徳, 猪股 雅史, 衛藤 剛, 安田一弘, 白石 憲男, 泥谷 直樹, 守山 正胤, 北野 正剛
  • Organizer: 第111回日本外科学会定期学術集会
  • Place of Presentation: 紙上開催