Precancerous lesion of the breast: Establishment of disease entity and verification of clinic-pathological significance
| Project/Area Number |
22590340
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
MORIYA Takuya 川崎医科大学, 医学部, 教授 (00230160)
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| Co-Investigator(Kenkyū-buntansha) |
KUREBAYASHI Junichi 川崎医科大学, 医学部, 准教授 (10248255)
SUZUKI Takashi 東北大学, 医学系研究科, 教授 (10261629)
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| Co-Investigator(Renkei-kenkyūsha) |
KANOMATA Naoki 川崎医科大学, 医学部, 准教授 (60263373)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 乳腺 / 乳癌 / 前癌病変 / 非浸潤癌 / 上皮内癌 / 異型過形成 / 診断病理学 / 免疫組 / 織化学 / 病理 / 免疫組織科学 / 非浸潤性乳管癌 / トリプルネガチブ乳癌 / 免疫組織化学 |
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| Research Abstract |
Most of breast cancers occur within the mammary duct, as ductal carcinoma in situ, and many cases will extend into invasive carcinoma in the future. However, precancerous stage as well as the way to advanced carcinoma may be variable. Thus, it is necessary to perform accurate pathological evaluation for individual patients, especially at the earlier stage, to predict the biological behavior for the appropriate therapy. In this research work, we pathologically examined ductal carcinoma in situ, and validated the hypothesis concerning the heterogeneity of the way to the development into invasive carcinoma. In addition, we showed that some ductal carcinoma in situ cases really have precancerous lesions detectable by pathological examination.
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Report
(4 results)
Research Products
(66 results)
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[Journal Article] Intratumoral estrogen concentration and expression of estrogen-induced genes in male breast carcinoma. Comparison with femalebreast carcinoma.2013
Author(s)
Takagi Kiyoshi, Moriya Takuya,Kusosumi Masafumi, Oka Kimako, Miki Yasuhiro,Ebata Akiko,Toshima Takashi, Tsunakawa Shoji, Takei Hiroyuki, Hirakawa Hisashi, Ishida Takanori, Hayashi Shinichi, Kurebayashi Junichi, Sasano Hironobu, Suzuki Takashi
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Journal Title
Horm Cancer
Volume: 4
Pages: 1-11
Related Report
Peer Reviewed
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[Journal Article] The Breast Cancer Working Group presentation was divided into three sections: the epidemiology, pathologyand treatment of breast cancer.2010
Author(s)
Toi Masakazu, Ohashi Yasuo, SeowAdeline, Moriya Takuya, Tse Gary, Sasano Hironobu, Park Byeong Woo, Chow Louis WC, Laudico Adriano V, Yip Cheng Har, Ueno Ei, Ishiguro Hiroshi, Bando Hiroko
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Journal Title
Jpn J Clin Oncol
Volume: 40(Suppl1)
Pages: 13-18
Related Report
Peer Reviewed
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[Journal Article] Molecular morphological approach to the pathological study of development and advancement of human breast cancer.2010
Author(s)
Moriya Takuya, Kanomata Naoki, Kozuka Yuji, Hirakawa Hisashi, Kimijima Izo, Kimura Michio, Eatanabe Mika, Sasano Hironobu, Ishida Takanori, Ohuchi Noriaki, Kurebayashi Junichi, Sonoo Hiroshi
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Journal Title
Med Mol Morpho
Volume: l43
Pages: 67-73
NAID
Related Report
Peer Reviewed
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