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The relationship among the genotypes of ALDH, telomere length, and chromosomal instability in the esophageal epithelium.

Research Project

Project/Area Number 22590343
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionTokyo Metropolitan Geriatric Hospital and Institute of Gerontology

Principal Investigator

IZUMIYAMA Naotaka  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 助手 (10158751)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Kenichi  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (60159069)
Co-Investigator(Renkei-kenkyūsha) AIDA Junko  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (80425678)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsテロメア / ALDH / Q-FISH / 食道 / 扁平上皮癌 / ALDH2 / ADH1B
Research Abstract

The investigation of the telomere lengths in the esophageal epithelium revealed that there is no difference among the ALDH genotype in telomere lengths, but the epithelium has short telomeres in the large iodine-unstained lesions with multiplicity. Telomere shortening may not generate cancer directly, but may create conditions under which SCC can develop more easily, depending on subsequent exposure to carcinogens.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (26 results)

All 2013 2012 2011 2010 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (13 results) Remarks (6 results)

  • [Journal Article] Telomere Shortening in the Esophagus of Japanese Alcoholics : Relationships with Chromoendoscopic Findings, ALDH2 and ADH1B Genotypes and Smoking History2013

    • Author(s)
      Aida J, Shimomura N, Nakamura K.
    • Journal Title

      PLOS One

      Volume: 8

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Telomere shortening in the esophagus of Japanese alcoholics: relationships with chromoendoscopic findings, ALDH2 and ADH1B genotypes and smoking history.2013

    • Author(s)
      Aida J, Yokoyama A, Shimomura N, Nakamura K, Ishikawa N, Terai M, Poon S, Matsuura M, Fujiwara M, Sawabe M, Arai T, Takubo K
    • Journal Title

      PloS one

      Volume: 8 Issue: 5 Pages: 1-7

    • DOI

      10.1371/journal.pone.0063860

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatocellular telomere length in biliary atresia measured by Q-FISH2012

    • Author(s)
      Sanada Y, Aida J, Kawano Y, Nakamura K, Shimomura N.
    • Journal Title

      World J Surg

      Volume: 36(4) Pages: 908-16

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Accelerated in vivo epidermal telomere loss in Werner syndrome2011

    • Author(s)
      Ishikawa N, Nakamura K, Izumiyama-Shimomura N, Aida J, Ishii A, Goto M, Ishikawa Y, Asaka R, Matsuura M, Hatamochi A, Kuroiwa M, Takubo K.
    • Journal Title

      Aging

      Volume: 3 Pages: 417-429

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alcoholics show reduced telomere length in the oesophagus.2011

    • Author(s)
      Aida J, Yokoyama A, Izumiyama-Shimomura N, Takubo K. 他
    • Journal Title

      J Pathol

      Volume: 223 Pages: 410-416

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alcoholics show reduced telomere length in the oesophagus2011

    • Author(s)
      Aida J, Yokoyama A, Izumiyama-Shimomura N, Nakamura K, Ishikawa N, Poon SSS, Fujiwara M, Sawabe M, Matsuura M, Arai T, Takubo K
    • Journal Title

      J Pathol

      Volume: 223 Issue: 3 Pages: 410-416

    • DOI

      10.1002/path.2817

    • URL

      http://www.thejournalofpathology.com

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alcoholics show reduced telomere length in the oesophagus2011

    • Author(s)
      Aida J, Izumiyama N, Nakamura K, Takubo K.
    • Journal Title

      J Pathol

      Volume: 223(3) Pages: 410-416

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] アルコール症患者における食道上皮のテロメア短縮 : 色素内視鏡所見、ADH-1BおよびALDH-2ジェノタイプによる検討2012

    • Author(s)
      相田順子、下村七生貴、仲村賢一、他5名
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 胆道閉鎖症肝のテロメア長と細胞老化関連β-galactosidase の解析2012

    • Author(s)
      眞田幸弘, 田久保海誉、相田順子、泉山七生貴、仲村賢一、他2名
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 食道扁平上皮癌の危険因子とテロメア : ALDH2, ADH1Bのgenotypeと色素内視鏡所見2012

    • Author(s)
      相田順子、泉山七生貴、仲村賢一、他6名
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-27
    • Related Report
      2012 Final Research Report
  • [Presentation] ウエルナー症候群患者皮膚テロメア長は正常人群と比べ急速に短縮する-TRF データの重回帰統計解析-2012

    • Author(s)
      石川 直, 仲村賢一, 田久保海誉、相田順子、泉山七生貴, 他3名
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Telomere Shortening in Esophageal Epithelium of Alcoholics : Differences in Terms of ADH-1B and ALDH-2 Genotypes and Chromoendoscopy Findings2012

    • Author(s)
      Aida J, Izumiyama-Shimomura N, Nakamura K, N,Takubo K. 他
    • Organizer
      101st Annual Meeting of United States & Canadian Academy of Pathology, Vancouver, Canada
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2012-03-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Telomere Shortening in Esophageal Epithelium of Alcoholics : Differences in Terms of ADH-1B and ALDH-2 Genotypes and Ghromoendoscopy Findings2012

    • Author(s)
      Aida J, Izumiyama-Shimomura N, Nakamura K, N, Takubo K, 他
    • Organizer
      101st Annual Meeting of United States & Canadian Academy of Pathology, Vancouver, Canada
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2012-03-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Q-FISH法による膀胱癌の悪性度とテロメア長2011

    • Author(s)
      仲村賢一, 田久保海誉、相田順子、泉山七生貴, 他4名
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Q-FISH法と免疫蛍光抗体法を用いた細胞種類別テロメア長の測定方法と膵島細胞種別テロメア長の解析2011

    • Author(s)
      泉山七生貴, 仲村賢一, 田久保海誉、相田順子, 他3名
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-30
    • Related Report
      2012 Final Research Report
  • [Presentation] アルコール症患者は食道上皮のテロメアが短縮している2011

    • Author(s)
      相田順子, 田久保海誉, 泉山七生貴、仲村賢一、他3名
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-29
    • Related Report
      2012 Final Research Report
  • [Presentation] テロメアの短縮とヒトの老化、癌化2011

    • Author(s)
      田久保海誉、相田順子、泉山七生貴、仲村賢一、他3名
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Measurement of telomeres in the esophagus of alcoholics by Q-FISH2010

    • Author(s)
      相田順子、泉山七生貴、仲村賢一
    • Organizer
      第69回日本癌学会総会
    • Place of Presentation
      リーガロイヤルホテル大阪
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 食道扁平上皮癌の危険因子とテロメア:ALDH2, ADH1Bのgenotypeと色素内視鏡所見

    • Author(s)
      相田順子、泉山七生貴、仲村賢一、他6名
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] アルコール症患者における食道上皮のテロメア短縮:色素内視鏡所見、ADH-1BおよびALDH-2ジェノタイプによる検討

    • Author(s)
      相田順子、下村七生貴、仲村賢一、他6名
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Remarks] 東京都健康長寿医療センター研究所 老年病理学研究チーム 高齢者がんグループホームページ

    • URL

      http://www.ttaggg-rtgp.org/

    • Related Report
      2012 Final Research Report
  • [Remarks] 東京都健康長寿医療センター

    • URL

      http://www.tmghig.jp/

    • Related Report
      2012 Final Research Report
  • [Remarks] 東京都健康長寿医療センター研究所 老年病理学研究チーム 高齢者がんグループホームページ

    • URL

      http://www.ttaggg-rtgp.org/

    • Related Report
      2012 Annual Research Report
  • [Remarks] 東京都健康長寿医療センター研究所ホームページ

    • URL

      http://www.tmig.or.jp/J_TMIG_J_index.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.ttaggg-rtgp.org/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.ttaggg-rtgp.org/

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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