Mechanisms of radiation-related pediatric thyroid cancer

• Project/Area Number: 22590344
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: 独立行政法人 国立病院機構 長崎医療センター・臨床研究センター (2012); Department of Clinical Research, National Hospital Organization Nagasaki Medical Center (2010-2011)
• Principal Investigator: ITOU Masahiro 独立行政法人 国立病院機構 長崎医療センター・臨床研究センター, 機能形態研究部, 部長 (30184691)
• Co-Investigator(Kenkyū-buntansha): NAKASHIMA Masahiro 長崎大学, 医歯(薬)学総合研究科, 教授 (50284683)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: Chernobyl / Thyroid cancer / Papillary carcinoma / Childhood / Radiation / Iodine / 甲状腺癌 / 放射線 / チェルノブイリ / 遺伝子不安定 / 低ヨード / 小児甲状腺がん / ret/PTC / 53BP1 / microRNA / BRAF

Research Abstract

The Chernobyl Tissue Bank has contributed to data/tissue collection and 4,288 cases have been registered. The age at diagnosis and the latency period from exposure to radiation were correlated with tumor morphology and aggressiveness. Low levels of iodine intake seemed to influence the formation of morphology. Specific genetic mutation by radiation injury has not been identified at individual levels.

Research Products

• [Journal Article] 放射線と甲状腺癌 (2013)
  • Author(s): 伊東 正博(加藤良平, 廣川満良(編))
  • Journal Title: 病理と臨床 Volume: 31(1) Pages: 1-12
  • Peer Reviewed
• [Journal Article] Long-term trend of thyroid cancer risk among Japanese atomic-bomb survivors: Sixty years after exposure. (2013)
  • Author(s): Furukawa K, Ito M
  • Journal Title: Int J Cancer. Volume: 132(5) Pages: 1222-1226
  • Peer Reviewed
• [Journal Article] 放射線と甲状腺癌の病理 (2013)
  • Author(s): 伊東正博
  • Journal Title: 病理と臨床 Volume: 31 Pages: 10-18
• [Journal Article] Long-term trend of thyroid cancer risk among Japanese atomic-bomb survivors: Sixty years after exposure. (2013)
  • Author(s): Furukawa K
  • Journal Title: Int J Cancer Volume: 132 Issue: 5 Pages: 1222-1226
  • DOI: 10.1002/ijc.27749
  • Peer Reviewed
• [Journal Article] Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population. (2012)
  • Author(s): Nakamura M
  • Journal Title: Am J Hum Genet. Volume: 91 Issue: 4 Pages: 721-728
  • DOI: 10.1016/j.ajhg.2012.08.010
  • Peer Reviewed
• [Journal Article] 放射線被曝後の甲状腺癌 (2012)
  • Author(s): 伊東正博
  • Journal Title: 検査と技術 Volume: 40 Pages: 1485-1489
• [Journal Article] 放射線被曝と甲状腺癌 (2012)
  • Author(s): 伊東正博
  • Journal Title: 内分泌・糖尿病・代謝内科 Volume: 34 Pages: 176-184
  • NAID: 40019237233
• [Journal Article] The Chernobyl thyroid cancer experience: Pathology. (2011)
  • Author(s): LiVolsi V, Ito M
  • Journal Title: Clin Oncol. Volume: 23(4) Pages: 261-267
  • Peer Reviewed
• [Journal Article] Mutational and clinico-pathological analysis of papillary thyroid carcinoma in Serbia (2011)
  • Author(s): Stanojevic B, Nakashima M
  • Journal Title: Endocr J. Volume: 58(5) Pages: 381-393
  • NAID: 10029588652
  • Peer Reviewed
• [Journal Article] The Chernobyl thyroid cancer experience : Pathology (2011)
  • Author(s): LiVolsi V, Ito M, et al
  • Journal Title: Clin Oncol Volume: 23 Issue: 4 Pages: 261-267
  • DOI: 10.1016/j.clon.2011.01.160
  • Peer Reviewed
• [Journal Article] Thyroid papillary carcinoma with solid sclerosing change in IgG4-related sclerosing disease (2011)
  • Author(s): Ito M, et al
  • Journal Title: Patho Int Volume: 61 Issue: 10 Pages: 589-592
  • DOI: 10.1111/j.1440-1827.2011.02701.x
  • NAID: 10030721298
  • Peer Reviewed
• [Journal Article] De novo papillary renal cell carcinoma in an allograft kidney : Evidence of donor origin (2011)
  • Author(s): Naruke Y, Ito M, Nakashima M, et al
  • Journal Title: Pathol Int Volume: 61 Issue: 11 Pages: 694-69
  • DOI: 10.1111/j.1440-1827.2011.02714.x
  • NAID: 10031185144
  • Peer Reviewed
• [Journal Article] Thyroid papillary carcinoma with solid sclerosing change in IgG4-related sclerosing disease. (2011)
  • Author(s): Ito M, et al.
  • Journal Title: Pathol Int Volume: (in press)
  • NAID: 10030721298
  • Peer Reviewed
• [Journal Article] Dynamics of ionizing radiation-induced DNA damage response in reconstituted three-dimensional human skin tissue (2010)
  • Author(s): Suzuki K, Nakashima M
  • Journal Title: Radiat Res. Volume: 174(4) Pages: 415-423
  • Peer Reviewed
• [Journal Article] Analysis of HLA-DRB1 polymorphisms in Japanese patients with primary biliary cirrhosis (PBC) : The HLA-DRB1polymorphism determines the relative risk of antinuclear antibodies for disease progression in PBC. (2010)
  • Author(s): Nakamura M, Ito M, et al.
  • Journal Title: Hepatol Res Volume: 40 Pages: 494-504
  • NAID: 10026392072
  • Peer Reviewed
• [Journal Article] Serum BAFF and APRIL levels in patients with PBC. (2010)
  • Author(s): Migita K, Ito M, et al.
  • Journal Title: Clin Immunol Volume: 134 Pages: 217-225
  • Peer Reviewed
• [Presentation] International Cooperation to Establish Post Chernobyl NIS Thyroid Tissue, Nucleic Acid and Data Banks (2012)
  • Author(s): Masahiro Ito
  • Organizer: 20th Pathology Panel Meeting
  • Place of Presentation: Charing Cross Hospital, Imperial、London
• [Presentation] チェルノブイリの甲状腺癌 (2012)
  • Author(s): 伊東正博
  • Organizer: 第101回日本病理学会
  • Place of Presentation: 東京
• [Presentation] ウクライナ成人の甲状腺乳頭癌の組織像は本邦症例とことなるのか? (2012)
  • Author(s): 伊東正博,Bogdanova T, Saenko V,前田茂人,近藤久義,山下俊一
  • Organizer: 第55回日本甲状腺学会
  • Place of Presentation: アクロス福岡
• [Presentation] チェルノブイリ組織バンクの現状と新たな展開 (2012)
  • Author(s): 伊東正博, Tatiana Bogdanova, Alexander Abrosimov, Guido Fadda, Jeniffer Hunt, Gerry Thomas, Virginia LiVolsi, 中島正洋、山下俊一
  • Organizer: 第55回日本放射線影響学会
  • Place of Presentation: 仙台
• [Presentation] 成熟ラット甲状腺放射線発がん過程でのゲノム不安定性の関与 (2012)
  • Author(s): 蔵重智美, 松山睦美, 七條和子, 鈴木啓司, 成毛有紀, 伊東正博, 中島正洋
  • Organizer: 第100回日本病理学会
  • Place of Presentation: 横浜
• [Presentation] 放射線と甲状腺癌 (2012)
  • Author(s): 伊東正博
  • Organizer: 第59回日本病理学会近畿支部学術集会
  • Place of Presentation: 京都
  • Invited
• [Presentation] ウクライナ成人の甲状腺乳頭癌の組織像は本邦症例と異なるのか？ (2012)
  • Author(s): 伊東正博
  • Organizer: 第55回日本甲状腺学会
  • Place of Presentation: 福岡
• [Presentation] 放射線誘発甲状腺癌の分子疫学的研究と組織バンク構築 (2012)
  • Author(s): 伊東正博
  • Organizer: 平成24年度がん研究開発費班会議:放射線への曝露による発がんの分子機構に関する斑研究報告会
  • Place of Presentation: 福島
• [Presentation] IgG4関連疾患に合併した甲状腺乳頭癌 (2012)
  • Author(s): 伊東正博
  • Organizer: 第101回日本病理学会
  • Place of Presentation: 東京
• [Presentation] ラット甲状腺濾胞上皮の放射線DNA損傷応答と発がん (2012)
  • Author(s): 中島正洋
  • Organizer: 第101回日本病理学会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 成熟ラット甲状腺濾胞上皮の放射線誘発晩発性DNA損傷応答と発がん (2012)
  • Author(s): 蔵重智美
  • Organizer: 第101回日本病理学会
  • Place of Presentation: 東京
• [Presentation] チェルノブイリの甲状腺癌 (2012)
  • Author(s): 伊東正博
  • Organizer: 第101回日本病理学会
  • Place of Presentation: 東京(招待講演)
• [Presentation] ラット甲状腺濾胞上皮の放射線DNA損傷応答と発がん (2012)
  • Author(s): 中島正洋、伊東正博, 他
  • Organizer: 第101回日本病理学会
  • Place of Presentation: 東京(招待講演)
• [Presentation] Zurnadzhy L, Thomas G. Thyroid cancer pathology in Ukraine after the Chernobyl accident (2011)
  • Author(s): Bogdanova T, LiVolsi V, Williams ED, Ito M,
  • Organizer: 7th NCRI Cancer Conference
  • Place of Presentation: CTB Symposium, Liverpool, UK
  • Year and Date: 2011-11-19
• [Presentation] Thyroid cancer pathology in Ukraine after the Chernobyl accident (2011)
  • Author(s): Bogdanova T, Ito M, et al
  • Organizer: 7^<th> NCRI Cancer Conference, CTB Symposium
  • Place of Presentation: Liverpool, UK(招待講演)
  • Year and Date: 2011-11-09
• [Presentation] チェルノブイリ組織バンク、11年間の活動報告 (2011)
  • Author(s): 伊東正博, 中島正洋, 他
  • Organizer: 第100回日本病理学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-04-30
• [Presentation] Pathology review of childhood thyroid cancer around Chernobyl (2011)
  • Author(s): Ito M, Bogdanova T, Abrosimov A, Fadda G, Hunt J, LiVolsi V, Thomas G, Nakashima M, Yamashita S.
  • Organizer: The 6th International Symposium of Nagasaki University Global COE Program "Global Strategic Center for Radiation Health Risk Control": A New Challenge of Radiation Health Risk Management
  • Place of Presentation: Nagasaki
• [Presentation] チェルノブイリ周辺の小児甲状腺癌の病理組織学的特徴 (2011)
  • Author(s): 伊東正博, Bogdanova T, Abrosimov A, Fadda G, Hunt J, Thomas G, LiVolsi V, 中島正洋、山下俊一
  • Organizer: 第54回日本甲状腺学会
  • Place of Presentation: 大阪国際交流センター
• [Presentation] Pathology review of childhood thyroid cancer around Chernobyl (2011)
  • Author(s): Ito M, Nkashima M, et al
  • Organizer: The 6th International Symposium of Nagasaki University Global COE Program "Global Strategic Center for Radiation Health Risk Control" : A New Challenge of Radiation Health Risk Management
  • Place of Presentation: 長崎(招待講演)
• [Presentation] チェルノブイリ組織バンク (2011)
  • Author(s): 伊東正博, 中島正洋, 他
  • Organizer: 第54回日本甲状腺学会
  • Place of Presentation: 大阪
• [Presentation] チェルノブイリ周辺の小児甲状腺癌の病理組織学的特徴 (2011)
  • Author(s): 伊東正博, 中島正洋, 他
  • Organizer: 第54回日本甲状腺学会
  • Place of Presentation: 大阪
• [Presentation] Immunofluorescence analysis of P53-binding protein 1 as a new molecular indicator for malignant potency and genomic instability in thyroid follicular neoplasms (2010)
  • Author(s): Mussazhanova Z,Nakashima M, Saenko V, Naryke Y, Suzuki K, Mitsutake N, Ito M, Nishihara E, Hirokawa M, Yamashita S.
  • Organizer: 第14回国際甲状腺学会
  • Place of Presentation: パリ, フランス
• [Presentation] Immunofluorescence analysis of P53-binding protein 1 as a new molecular indicator for malignant potency and genomic instability in thyroid follicular neoplasms (2010)
  • Author(s): Naruke Y, Nakashima M, Ito M, et al.
  • Organizer: 第14回国際甲状腺学会
  • Place of Presentation: パリ、フランス
• [Book] Pathology review of childhood thyroid cancer around Chernobyl. In Nakashima M, Takamura N, Suzuki K, Yamashita S (Eds). A new challenge of radiation health risk management (2012)
  • Author(s): Ito M, Bogdanova T, Nakashima M
  • Publisher: Nagasaki Newspaper Publish
• [Book] Pathology review of childhood thyroid cancer around Chernobyl. In Nakashima M, Takamura N, Suzuki K, Yamashita S (Eds). A new challenge of radiation health risk management (2012)
  • Author(s): Ito M
  • Publisher: Nagasaki Newspaper Publisher
• [Book] Pathology review of childhood thyroid cancer around Chernobyl.In A new challenge of radiation health risk management(Nakashima M, Takamura N, Suzuki K, Yamashita S (Eds)) (2012)
  • Author(s): Ito M, Nakashima M, et al
  • Publisher: Nagasaki Newspaper Publisher
• [Book] II.放射線被曝と甲状腺癌:「腫瘍病理鑑別診断アトラス 8.甲状腺癌」 坂本穆彦,廣川満良(編) (2011)
  • Author(s): 伊東 正博
  • Publisher: 文光堂
• [Book] 腫瘍病理鑑別診断アトラス甲状腺癌 (2011)
  • Author(s): 伊東正博(分担)
  • Publisher: 文光堂
• [Book] 腫瘍病理鑑別診断アトラス 甲状腺癌 (2011)
  • Author(s): 伊東正博(分担)
  • Publisher: 文光堂