Study of novel pathogenesis and its availability of therapeutic target for diabetes-associated microangiopathy
| Project/Area Number |
22590347
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YONEMITSU Yoshikazu 九州大学, 大学院・薬学研究院, 客員教授 (40315065)
IKEDA Yasuhiro 九州大学, 大学院・医学研究院, 助教 (20380389)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 糖尿病 / 微小血管障害 / 受容体可溶型変換 / 糖尿病微小血管障害 / Tie-2 / 可溶型変換 / PKC / 可溶性変換 |
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| Research Abstract |
Structural stability of microvessels is critical for exerting physiological function of microvessels. It has been indicated that the microvessel structure is affected under condition of diabetes Mellitus (DM). This study demonstrated a possibility that an indispensable receptor (Tie) for microvessel stabilization was degraded by a certain protease (MMP-14), resulting in causing physiological dysfunction of microvessels. Hence, further study of relationship between DM and MMP-14 activity is significant with the object of incarnating availability of therapeutic target for DM.
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Report
(4 results)
Research Products
(27 results)
