| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Structural stability of microvessels is critical for exerting physiological function of microvessels. It has been indicated that the microvessel structure is affected under condition of diabetes Mellitus (DM). This study demonstrated a possibility that an indispensable receptor (Tie) for microvessel stabilization was degraded by a certain protease (MMP-14), resulting in causing physiological dysfunction of microvessels. Hence, further study of relationship between DM and MMP-14 activity is significant with the object of incarnating availability of therapeutic target for DM.
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