Significance of triglyceride metabolism in human vascular smooth muscle cell phenotype
Project/Area Number |
22590349
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Experimental pathology
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Research Institution | University of the Ryukyus |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KATO Seiya 琉球大学, 大学院・医学研究科, 教授 (60268844)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 血管平滑筋細胞 / トリグリセリド / 脂質代謝 / ATGL / 細胞 / 脂肪酸代謝 |
Research Abstract |
VSMC could use TG mediated ATGL as an cellular energy. TG load in VSMC provided TG accumulation and enhanced TG metabolism and associated with inflammatory phenotype. In addition, coordination of ATGL expression level and beta-oxidation level was probably responsible for inflammatory phenotype. We believe that this culture model is useful in resolution of inflammatory mechanism in neointima and relationship between TG metabolism and atherosclerosis.
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Report
(4 results)
Research Products
(13 results)
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[Presentation] 血管平滑筋細胞の古典的形質転換と炎症性形質転換2011
Author(s)
加藤誠也, Lin Yanhui, 松本裕文, 新垣和也, 又吉宣, 仲西貴也, 千葉俊明, 荒川文子, 大島孝一, 洲鎌和茂
Organizer
第100回日本病理学会総会
Place of Presentation
神奈川県横浜市パシフィコ横浜
Year and Date
2011-04-30
Related Report
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