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The role of mouse APOBEC3 in the regulation of endogenous retrovirus

Research Project

Project/Area Number 22590352
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionKinki University

Principal Investigator

KAWAHARA Sachiyo  近畿大学, 医学部, 講師 (60297629)

Co-Investigator(Kenkyū-buntansha) MIYAZAWA Masaaki  近畿大学, 医学部, 教授 (60167757)
HAKATA Yoshiyuki  近畿大学, 医学部, 助教 (30344500)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords発がん制御 / 内在性レトロウイルス / APOBEC3 / 乳癌 / リンパ腫 / 白血病
Research Abstract

Mouse APOBEC3, a host factor that restricts the replication of exogenous retrovirus, is abundantly expressed in virus-resistant C57BL/6 (B6) mice. We have found that loss of APOBEC3 causes spontaneous mammary carcinoma and T cell lymphomas in B6 mice. The transcripts of endogenous mouse mammary tumor virus are abundant in the tumor cells prepared from APOBEC3-deficient mice. These results suggest that APOBEC3 contributes to the control of activated endogenous retrovirus.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (28 results)

All 2012 2011 2010 Other

All Journal Article (14 results) (of which Peer Reviewed: 12 results) Presentation (13 results) Remarks (1 results)

  • [Journal Article] Molecular evolution of physiologically functioning anti-retroviral APOBEC3 deaminases2012

    • Author(s)
      Miyazawa M
    • Journal Title

      Uirusu

      Volume: 62 Pages: 27-38

    • NAID

      10030767931

    • URL

      http://dx.doi.org/10.2222/jsv.62.27

    • Related Report
      2012 Final Research Report
  • [Journal Article] Molecular evolution of physiologically functioning anti-retroviral APOBEC3 deaminases.2012

    • Author(s)
      Miyazawa M. et al.
    • Journal Title

      ウイルス

      Volume: 62 Pages: 27-38

    • NAID

      10030767931

    • Related Report
      2012 Annual Research Report
  • [Journal Article] In vivo diagnostic imaging using micro-CT: sequential and comparative evaluation of rodent models for hepatic/brain ischemia and stroke.2012

    • Author(s)
      Hayasaka N. et al.
    • Journal Title

      PLoS One

      Volume: 7

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two genetic determinants acquired late in Mus evolution regulate the inclusion of exon 5, which alters mouse APOBEC3 translation efficiency2012

    • Author(s)
      Li, J., Y. Hakata, E. Takeda, Q. Liu, Y. Iwatani, C. A. Kozak, M. Miyazawa
    • Journal Title

      PLoS Pathogens

      Volume: 8 Issue: 1 Pages: e1002478-e1002478

    • DOI

      10.1371/journal.ppat.1002478

    • NAID

      120006985441

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two genetic determinants acquired late in mus evolution regulate the inclusion of exon 5,which alters mouse APOBEC3 translation efficiency2011

    • Author(s)
      Li J, Hakata Y, Takeda E, Liu Q, Iwatani Y, Kozak CA, Miyazawa M
    • Journal Title

      PLoS Pathog

      Volume: 8(1)

    • NAID

      120006985441

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A hole in the T-cell repertoire induced after retroviral infection of immunocompetent adult mice2011

    • Author(s)
      Miyazawa, M., S. Takamura, S. Tsuji-Kawahara, E. Kajiwara, T. Chikaishi, and M. Kato
    • Journal Title

      Retrovirol

      Volume: 8 (Suppl. 2)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Natural killer cells recognize friend retrovirus-infected erythroid progenitor cells through NKG2D-RAE-1 interactions in Vivo2011

    • Author(s)
      Ogawa T*, Tsuji-Kawahara S*, Yuasa T, Kinoshita S, Chikaishi T, Takamura S, Matsumura H, Seya T, Saga T, Miyazawa M
    • Journal Title

      J Virol

      Volume: 85 Pages: 5423-35

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Attenuated Food Anticipatory Activity and Abnormal Circadian Locomotor Rhythms in Rgs16 Knockdown Mice2011

    • Author(s)
      Hayasaka N, Aoki K, Kinoshita S, Yamaguchi S, Wakefield J. K, Tsuji-Kawahara S, Horikawa K, Ikegami H, Wakana S, Murakami T, Ramabhadran R, Miyazawa M, and Shibata S
    • Journal Title

      PLoS ONE

      Volume: 6

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Natural killer cells recognize friend retrovirus-infected erythroid progenitor cells through NKG2D-RAE-1 interactions in vivo2011

    • Author(s)
      Ogawa T., et al
    • Journal Title

      J.Virol.

      Volume: 85 Pages: 5423-35

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Attenuated Food Anticipatory Activity and Abnormal Circadian Locomotor Rhythms in Rgs16 Knockdown Mice.2011

    • Author(s)
      Hayasaka N, Aoki K, Kinoshita S, Yamaguchi S, Wakefield J.K, Tsuji-
    • Journal Title

      Plos ONE

      Volume: 6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Persistence of viremia and production of neutralizing antibodies differentially regulated by polymorphic APOBEC3 and BAFF-R loci in Friend virus-infected mice2010

    • Author(s)
      Tsuji-Kawahara S, Chikaishi T., Takeda E., Kato M., Kinoshita S., Kajiwara E., Takamura S., and Miyazawa M
    • Journal Title

      J. Virol

      Volume: 84 Pages: 6082-95

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Premature terminal exhaustion of friend virus-specific effector CD8(+) T cells by rapid induction of multiple inhibitory receptors2010

    • Author(s)
      Takamura S, Tsuji-Kawahara S, Yagita H, Akiba H, Sakamoto M, Chikaishi T, Kato, M, Miyazawa M
    • Journal Title

      J Immunol

      Volume: 184 Pages: 4696-707

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Persistence of viremia and production of neutralizing antibodies differentially regulated by polymorphic APOBEC3 and BAFF-R loci in Friend virus-infected mice.2010

    • Author(s)
      Tsuji-Kawahara S, Chikaishi T., Takeda E., Kato M., Kinoshita S., Kajiwara E.
    • Journal Title

      J.Virol.

      Volume: 84 Pages: 6082-6095

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Premature terminal exhaustion of friend virus-specific effector CD8(+) T cells by rapid induction of multiple inhibitory receptors.2010

    • Author(s)
      Takamura S, Tsuji-Kawahara S, Yagita H, Akiba H, Sakamoto M, Chikaishi T, Kato
    • Journal Title

      J.Immunol.

      Volume: 184 Pages: 4696-4707

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Rapid production of virus-neutralizing IgM antibodies and protection against lethal retroviral infection in mice deficient of activation-induced cytidine deaminase (AID)2012

    • Author(s)
      Miyazawa M, Tsuji-Kawahara S
    • Organizer
      24th Workshop on Retrovirla Pathogenesis
    • Place of Presentation
      Philadelphia PA
    • Year and Date
      2012-10-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Vpr依存的G2期停止におけるVprと宿主因子との分子間相互作用2012

    • Author(s)
      博多義之
    • Organizer
      第60回日本ウイルス学会
    • Place of Presentation
      大阪市 大阪国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Rapid production of virus-neutralizing IgM antibodies and protection against lethal retroviral infection in mice deficient of activation-induced cytidine deaminase (AID)2012

    • Author(s)
      Miyazawa M.
    • Organizer
      24th Workshop on Retrovirla Pathogenesis
    • Place of Presentation
      philadelphia, PA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Production of virus-neutralizing antibodies and protection against lethal retroviral infection in mice deficient of activation-induced2011

    • Author(s)
      Kato M., et al
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉市幕張メッセ
    • Year and Date
      2011-11-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Infection of thymus with murine retrovirus induces virus-specific central tolerance that prevents dynamic differentiation of functional memory CD8+ T cells2011

    • Author(s)
      Takamura S., et al
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉市幕張メッセ
    • Year and Date
      2011-11-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Host immune responses detarmine integration of either F-MuLV alone or F-MuLV plus SFFV in Friend virus leukemogenesis2011

    • Author(s)
      Miyazawa M., et al
    • Organizer
      The 23rd Workshop on Retroviral pathogenesis
    • Place of Presentation
      Monpellier, France
    • Year and Date
      2011-11-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Functional consequences of mouse APOBEC3 gene polymorphisms and multiple genetic factors that influence the production of virus-neutralizing antibodies in Friend virus-infected mice2011

    • Author(s)
      Miyazawa M., et al
    • Organizer
      The 23rd Workshop on Retroviral pathogenesis
    • Place of Presentation
      Monpellier, France
    • Year and Date
      2011-11-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] A hole in the T-cell repertoire induced after retroviral infection of immunocompetent adult mice2011

    • Author(s)
      Miyazawa M., et al
    • Organizer
      Frontiers of Retrovirology
    • Place of Presentation
      Amsterdam, The Netherlands
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] A hole in the T-cellrepertoire induced after retroviral infection ofimmunocompetent adult mice2011

    • Author(s)
      Miyazawa, M., Tsuji-Kawahara S
    • Organizer
      Frontiers of Retrovirology
    • Place of Presentation
      Amsterdam, The Netherlands
    • Related Report
      2012 Final Research Report
  • [Presentation] Host immune responses determine integration of either F-MuLV alone or F-MuLV plus SFFV in Friend virus leukemogenesis2011

    • Author(s)
      Miyazawa, M., Tsuji-Kawahara S
    • Organizer
      The 23rd Workshop on Retrovirla Pathogenesis
    • Place of Presentation
      Montpellier, Farance
    • Related Report
      2012 Final Research Report
  • [Presentation] Polymorphisms in mouse APOBEC3 influence the production of virus-neutralizing antibodies by altering the levels of retrovirus-induced B-cell dysfunction2010

    • Author(s)
      Tsuji-Kawahara, S
    • Organizer
      第14回国際免疫学会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-08-26
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] Premature terminal exhaustion of Friend virus-specific effector CD8+ T cells by rapid induction of multiple inhibitory receptors2010

    • Author(s)
      Takamura S., Tsuji-Kawahara, S., Miyazawa, M
    • Organizer
      第14回国際免疫学会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-08-26
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] Rac2が発揮する抗HIV-1活性の分子機構2010

    • Author(s)
      Hakata Y
    • Organizer
      第58回日本ウイルス学会
    • Place of Presentation
      徳島市
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.med.kindai.ac.jp/immuno/

    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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