| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
t was revealed that PLK4 is overexpressed in a subset of gastric cancersand the overexpression of PLK4 induces centrosome amplification and chromosome instability. It was also revealed that PLK4 has activity to suppress primary cilia formation. A novel SGOL1 variant(SGOL1-P1), which is cancer-specific, was identified in colorectal cancer. Overexpression of the variant caused aberrant chromosome alignment, precociously separated chromatids, delayed mitotic progression, centrosome amplification, and chromosome instability. It was revealed that a part of AID is localized at the centrosomes, AID is aberrantly expressed in a subset of lung cancers, and the AID overexpression causesincreased spontaneous mutation.
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