Study on the abnormal centrosome regulation, leading to the chromosome instability in cancer
| Project/Area Number |
22590356
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 中心体 / 染色体不安定性 / がん / 中心体過剰複製 / PLK4 / SGOL1 / AID / 中心体サイクル / MUTYH / 胃がん / 遺伝子増幅 / 色体不安定性 / 大腸がん / 肺がん |
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| Research Abstract |
t was revealed that PLK4 is overexpressed in a subset of gastric cancersand the overexpression of PLK4 induces centrosome amplification and chromosome instability. It was also revealed that PLK4 has activity to suppress primary cilia formation. A novel SGOL1 variant(SGOL1-P1), which is cancer-specific, was identified in colorectal cancer. Overexpression of the variant caused aberrant chromosome alignment, precociously separated chromatids, delayed mitotic progression, centrosome amplification, and chromosome instability. It was revealed that a part of AID is localized at the centrosomes, AID is aberrantly expressed in a subset of lung cancers, and the AID overexpression causesincreased spontaneous mutation.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Detection of kinase amplifications in gastric cancer archives using fluorescence in situ hybridization2011
Author(s)
Kiyose S, Nagura K, Tao H, Igarashi H, Yamada H, Goto M, Maeda M, Kurabe N, Suzuki M, Tsuboi M, Kahyo T, Shinmura K, Hattori N, Sugimura H
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Journal Title
Pathol Int
Volume: 62
Issue: 7
Pages: 477-484
DOI
Related Report
Peer Reviewed
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[Journal Article] Suppression of hydroxyurea-induced centrosome amplification by NORE1A and down-regulation of NORE1A mRNA expression in non-small cell lung carcinoma2011
Author(s)
Shinmura K, Tao H, Nagura K, Goto M, Matsuura S, Mochizuki T,SuzukiK, Tanahashi M, Niwa H, Ogawa H, Sugimura H
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Journal Title
Lung Cancer
Volume: 71
Issue: 1
Pages: 19-27
DOI
Related Report
Peer Reviewed
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[Journal Article] Aberrant expression and mutation-inducing activity of AID in human lung cancer2011
Author(s)
Shinmura K, Igarashi H, Goto M, Tao H, Yamada H, Matsuura S, Tajima M, Matsuda T, Yamane A, Funai K, Tanahashi M, Niwa H, Ogawa H, Sugimura H
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Journal Title
Ann Surg Oncol
Volume: 18
Issue: 7
Pages: 2084-2092
DOI
Related Report
Peer Reviewed
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