MG23-mediatedcrosstalk between genetic system and immune system.
| Project/Area Number |
22590359
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
YAMAZAKI Tetsuo 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (90330208)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 小胞体 / 細胞死 / シグナル伝達 / 紫外線 / DNA損傷 / ゲノム / 免疫応答 |
|---|
| Research Abstract |
The endoplasmic reticulum (ER) operates in adaptive responses to various stresses, dictating cell fate. Here we show thatknockdown of the ER protein mitsugumin23 (MG23) enhances cell death induced by ultraviolet C (UVC), which causes DNA damage. The small heat shock protein αB-crystallin (αBC) is identified as a MG23 binding molecule and its knockdown facilitates death of UVC-exposed cells. Conversely, αBC lowered UVC sensitivity when expressed as an ER-anchored form. Taken together, the results suggest that MG23plays a protective role against UVC by accumulating αBC in the close vicinity of the ER.
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Report
(4 results)
Research Products
(15 results)
