| Project/Area Number |
22590361
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Ehime University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KURATA Mie 愛媛大学, 大学院・医学系研究科, 講師 (80423440)
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| Co-Investigator(Renkei-kenkyūsha) |
NOSE Masato 東北大学, 大学院・医学研究科, 客員教授 (70030913)
HASEGAWA Hitoshi 愛媛大学, 大学院・医学系研究科, 准教授 (40164826)
FUJINO Takahiro 愛媛大学, 総合科学研究支援センター, 准教授 (40292312)
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| Research Collaborator |
TANAKA Yuki 愛媛大学, 総合科学研究支援センター, 技術職員
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 炎症 / オステオポンチン / 立体構造 / 競合的阻害 / 膠原病治療モデル |
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| Research Abstract |
We objected to propose a therapeutic model with a certain kind of novel protein analogs inhibiting the binding site of osteopontin (Opn) which is one of the susceptibility polymorphic gene product to glomerulonephritis in mouse model. Screening of the inhibiting protein against Opn function was carried out by Alpha Screen system and GST-capture ELISA followed by the in vivo andin vitro assays which resulted in the suppression of T-cell activation as well as thedevelopment of glomerulonephritis.
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