Fundamental study of patholofgival role of CCL8 in GVHD

• Project/Area Number: 22590365
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Sapporo Medical University
• Principal Investigator: KOKAI Yasuo 札幌医科大学, 医学部, 教授 (20178239)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 再生医学 / 造血幹細胞移植 / 移植片対宿主病 / GVHD / バイオマーカー / 客観診断 / 治療効果判定 / 予後予測 / CCL8 / biomarker / plasma / serum / proteomics / prognosis / outcome / アレルギー・喘息 / プロテオーム / トランスレーショナルリサーチ

Research Abstract

The early and preclinical expression of CCL8 in plasma predicts overall survival of GVHD in vivo. Together with an involvement of allorecognition in CCL8 expression, it suggests that CCL8 plays an important role in GVHD pathology.

Research Products

• [Journal Article] Evaluation of annexin A5 as a biomarker for Alzheimer's disease and Dementia with Lewy bodies (2013)
  • Author(s): Sohma H, Imai S, Takei N, Honda H, Matsumoto K, Utsumi K, Matsuki K, Hashimoto E, Saito T, Kokai Y
  • Journal Title: Frontiers in Aging Neuroscience Volume: 5 Pages: 15-23
  • Peer Reviewed
• [Journal Article] Metalothionein deficiency in the injured peripheral nerves of complex regional pain syndrome as revealed by proteomics (2012)
  • Author(s): Oki G, Wada T, Iba K, Aiki H, Sasaki K, Imai S, Sohm H, Matsumoto K, Yamaguchi M, Fujimiya M, Yamashita T, Kokai Y
  • Journal Title: Pain Volume: 153 Pages: 532-9
  • Peer Reviewed
• [Journal Article] Oral administration of monogalactosyl diacylglycerol from spinach inhibits colon tumor growth in mice. (2012)
  • Author(s): Maeda N
  • Journal Title: Exp Ther Med Volume: 5 Pages: 17-22
  • Peer Reviewed
• [Journal Article] Early expression of plasma CCL8 closely correlates with survival rate of acute graft-versus-host disease in mice (2011)
  • Author(s): Yamamoto M, Ota A, Hori T, Imai S, Sohma H, Suzuki N, Hatakeyama N, Inazawab N, Ito M-Y, Kimura H, Tsutsumi H, Kokai Y
  • Journal Title: Exp Hematol Volume: 39(11) Pages: 1101-11112
  • Peer Reviewed
• [Journal Article] Apolipoprotein E4 freauencies in Japanese population with Alzheimer's disease and dementia with Lewy bodies (2011)
  • Author(s): Kobayashi S, Tateno M, Woo T, Utsumi K, Sohma H, Ito Y-M, Kokai Y, Saito T
  • Journal Title: PLos ONE Volume: 6(4) Pages: 1-5
  • Peer Reviewed
• [Journal Article] Early expression of plasma CCL8 closely correlates with survival rate of acute graft-versus-host disease in mice (2011)
  • Author(s): Yamamoto M, Ota A, Hori T, Imai S, Sohma H, Suzuki N, Hatakeyama N, Inazawab N, Ito M-Y, Kimura H, Tsutsumi H, Kokai Y
  • Journal Title: Exp Hematol (2011) Volume: 39(11) Pages: 1101-1112
  • Peer Reviewed
• [Journal Article] Proteomics analysis in 28 patients with systemic IgG4-related plasmacytic syndrome. (2010)
  • Author(s): Yamamoto M, et al
  • Journal Title: Rheumatol Int. Volume: 30 Pages: 565-568
  • Peer Reviewed
• [Remarks]
  • URL: http://web.sapmed.ac.jp/bme/