Therapeutic approach to lung cancer and malignant mesothelioma by inhibition of VEGR-VEGFR pathway

• Project/Area Number: 22590366
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Kyorin University (2011-2012); Yokohama City University (2010)
• Principal Investigator: SHIMOYAMADA Hiroaki 杏林大学, 医学部, 助教 (60381472)
• Co-Investigator(Kenkyū-buntansha): YAZAWA Takuya 杏林大学, 医学部, 准教授 (50251054) ; OKUDELA Koji 横浜市立大学, 医学部, 助教 (10326027)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 血管内皮増殖因子 / Egr-1 / 肺癌 / VEGF / 中皮腫 / NAB2 / 悪件中皮腫 / 悪性中皮腫

Research Abstract

In summary, we have demonstrated that Early Growth Response Protein (Egr)-1 up-regulates the expression of VEGF-A in lung cancer cells by binding at specific sites in the VEGF-A promoter and that NAB2, a Egr-1 corepressor, probably form a negative feedback system for the Egr-1-VEGF-A expression. Egr-1 and NAB-2 may be useful as novel pharmaceutical targets in lung cancers.

Research Products

• [Journal Article] (2013)
  • Author(s): Sakata R, Shimoyamada H, Yanagisawa M, Murakami T, Makiyama K, Nakaigawa N, Inayama Y, Ohashi K, Nagashima Y, Yao M, Kubota Y
  • Journal Title: Nonfunctioning juxtaglomerular cell tumor. Pages: 973865-973865
• [Journal Article] POU domain transcription factor BRN2 is crucial for expression of ASCL1, ND1 and neuroendocrine marker molecules and cell growth in small cell lung cancer (2013)
  • Author(s): Ishii J, Sato H, Sakaeda M, Shishido-Hara Y, Hiramatsu C, Kamma H, Shimoyamada H, Fujiwara M, Endo T, Aoki I, Yazawa T.
  • Journal Title: Pathol Int. Volume: 63(3) Pages: 158-68
• [Journal Article] Neural lineage-specific homeoprotein BRN2 is directly involved in TTF1 expression in small-cell lung cancer (2013)
  • Author(s): Sakaeda M, Sato H, Ishii J, Miyata C, Kamma H, Shishido-Hara Y, Shimoyamada H, Fujiwara M, Endo T, Tanaka R, Kondo H, Goya T, Aoki I, Yazawa T.
  • Journal Title: Lab Invest Volume: 93(4) Pages: 408-21
• [Journal Article] Gastric metastasis from a primary renal leiomyosarcoma. (2012)
  • Author(s): Yodonawa S, Ogawa I, Yoshida S, Ito H, Kato A, Kubokawa R, Tokoshima E, Shimoyamada H
  • Journal Title: Case Rep Gastroenterol Volume: 6(2) Pages: 314-8
• [Journal Article] Differences of molecular expression mechanisms among neural cell adhesion molecule 1, synaptophysin, and chromogranin A in lung cancer cells (2012)
  • Author(s): Kashiwagi K, Ishii J, Sakaeda M, Arimasu Y, Shimoyamada H, Sato H, Miyata C, Kamma H, Aoki I, Yazawa T.
  • Journal Title: Pathol Int. Volume: 62(4) Pages: 232-45
  • NAID: 10031185195
• [Journal Article] Insulin-like growth factor binding protein-4 gene silencing in lung adenocarcinomas. (2011)
  • Author(s): Sato H, Sakaeda M, Ishii J, Kashiwagi K, Shimoyamada H, Okudela K, Tajiri M, Ohmori T, Ogura T, Woo T, Masuda M, Hirata K, Kitamura H, Yazawa T.
  • Journal Title: Pathol Int. Volume: 61(1) Pages: 19-27
  • NAID: 10031185042
• [Journal Article] Proposal of an improved histological sub-typing system for lung adenocarcinoma - significant prognostic values for stage I disease. (2010)
  • Author(s): Okudela K, Woo T, Mitsui H, Yazawa T, Shimoyamada H, Tajiri M, Ogawa N, Masuda M, Kitamura H.
  • Journal Title: Int J Clin Exp Pathol. Volume: 3(4) Pages: 348-66
• [Journal Article] Early growth response-1 induces and enhances vascular endothelial growth factor-A expression in lung cancer cells. (2010)
  • Author(s): Shimoyamada H, Yazawa T, Sato H, Okudela K, Ishii J, Sakaeda M, Kashiwagi K, Suzuki T, Mitsui H, Woo T, Tajiri M, Ohmori T, Ogura T, Masuda M, Oshiro H, Kitamura H
  • Journal Title: Am J Pathol Volume: 177(1) Pages: 70-83
• [Journal Article] Morphometric profiling of lung cancers-its association with clinicopathologic, biologic, and molecular genetic features (2010)
  • Author(s): Okudela K, Woo T, Mitsui H, Yazawa T, Shimoyamada H, Tajiri M, Ogawa N, Masuda M, Kitamura H.
  • Journal Title: Am J Surg Pathol Volume: 34(2) Pages: 243-55
• [Journal Article] Early growth response-1 induces and enhances vascular endothelial Growth factor-A expression in lung cancer cells (2010)
  • Author(s): 下山田博明
  • Journal Title: The American Journal of Pathology Volume: 177 Pages: 70-83
  • Peer Reviewed
• [Presentation] 甲状腺癌においてTTF-1により発現変化する遺伝子の網羅的解析 (2012)
  • Author(s): 下山田博明
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 東京
• [Book] 臨床画像No.9 (2012)
  • Author(s): 下山田博明
  • Publisher: メジカルビュー社
• [Remarks] 杏林大学医学部病理学教室
  • URL: http://www.kyorin-u.ac.jp/univ/faculty/medicine/education/labo/pathology/