• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Basic research for investigation of novel oncogenic mechanism by TLS-CHOP chimeric oncoprotein and its clinical application

Research Project

Project/Area Number 22590367
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionWakayama Medical University

Principal Investigator

OIKAWA Kosuke  和歌山県立医科大学, 医学部, 講師 (70348803)

Co-Investigator(Kenkyū-buntansha) MURAGAKI Yasuteru  和歌山県立医科大学, 医学部, 教授 (40190904)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords腫瘍 / キメラ遺伝子 / TLSーCHOP / 粘液型脂肪肉腫 / TLS-CHOP
Research Abstract

The TLS-CHOP fusion gene derived from chromosomal translocation is myxoid liposarcoma-specific oncogene. However, its oncogenesis mechanism and functions in tumor cells are still unclear. In this study, we have revealed that TLS-CHOP represses an anticancer cytokine MDA-7/IL-24 expression, and represses miR-486 that targets a tumor cell growth and metastasis activator PAI-1 In addition, a novel molecular pathway that induces expression of a tumorigenesis-related protein PRG4 has been suggested.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (46 results)

All 2012 2011 2010 Other

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (30 results)

  • [Journal Article] TLS-CHOP represses miR-486 expression, inducing upregulation of a metastasis regulator PAI-1 in human myxoid liposarcoma2012

    • Author(s)
      N. Borjigin, S. Ohno, W. Wu, M. Tanaka, R. Suzuki, K. Fujita, M. Takanashi, K. Oikawa, T. Goto, T. Motoi, T. Kosaka, K. Yamamoto, M. Kuroda
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 427 Issue: 2 Pages: 355-360

    • DOI

      10.1016/j.bbrc.2012.09.063

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] MicroRNAs that target Ca2+ transporters are involved in vascular smooth muscle cell calcification2012

    • Author(s)
      T. Gui, G. Zhou, Y. Sun, A. Shimokado, S. Itoh, K. Oikawa, Y. Muragaki
    • Journal Title

      Lab. Invest

      Volume: 92 Issue: 9 Pages: 1250-1259

    • DOI

      10.1038/labinvest.2012.85

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel oncogenic pathway by TLS-CHOP involving repression of MDA-7/IL-24 expression2012

    • Author(s)
      K. Oikawa, M. Tanaka, S. Itoh, M. Takanashi, T. Ozaki, Y. Muragaki, M. Kuroda
    • Journal Title

      Br. J. Cancer

      Volume: 106 Issue: 12 Pages: 1976-1979

    • DOI

      10.1038/bjc.2012.199

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a novel role of Septin 10 in Paclitaxel-resistance in cancers through a functional genomics screen2012

    • Author(s)
      Xu M, Takanashi M, Oikawa K, Nishi H, Isaka K, Yoshimoto T, Ohyashiki J, Kuroda M
    • Journal Title

      Cancer Sci

      Volume: 103 Issue: 4 Pages: 821-827

    • DOI

      10.1111/j.1349-7006.2012.02221.x

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fibulin-5 Protein Is Reduced in the Lung of Patients with Spontaneous Pneumothorax Who Are Under 25 Years Old2012

    • Author(s)
      Y. Hirai, Y. Muragaki, S. Itoh, K. Oikawa, M. Juri, T. Kondo, Y. Okamura
    • Journal Title

      Annals of Thoracic and Cardiovascular Surgery

      Volume: 18 Issue: 3 Pages: 200-205

    • DOI

      10.5761/atcs.oa.11.01758

    • NAID

      10030789489

    • ISSN
      1341-1098, 2186-1005
    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] ibulin-5 Protein Is Reduced in the Lung of Patients with Spontaneous Pneumothorax Who Are Under 25 Years Old2012

    • Author(s)
      K Hirai
    • Journal Title

      Annals of Thoracic and Cardiovascular Surgery

      Volume: 18 Pages: 200-205

    • DOI

      10.5761/atcs.cr.11.01758

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant expression of the P2 promoter-specific transcript Runx1 in epiphyseal cartilage of Trps1-null mice2011

    • Author(s)
      S. Kanno, T. Gui, S. Itoh, Z. Gai, Y. S u n , K. Oikawa, M. Yoshida, Y. Muragaki
    • Journal Title

      Exp. Mol. Pathol

      Volume: 90 Issue: 2 Pages: 143-148

    • DOI

      10.1016/j.yexmp.2010.11.010

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Loss of Smad3 gives rise to poor soft callus formation and accelerates early fracture healing2011

    • Author(s)
      M. Kawakatsu, S. Kanno, T. G u i, Z. Gai, S. Itoh, H. Tanishima, K. Oikawa, Y. Muragaki
    • Journal Title

      Exp. Mol. Pathol

      Volume: 90 Issue: 1 Pages: 107-115

    • DOI

      10.1016/j.yexmp.2010.10.011

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Loss of Smad3 gives rise to poor soft callus formation and accelerates early fracture healing2011

    • Author(s)
      川勝基久
    • Journal Title

      Experimental and Molecular Pathology

      Volume: 90巻 Pages: 107-115

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant expression of the P2 promoter-specific transcript Runx1 in epiphyseal cartilage of Trps1-null mice2011

    • Author(s)
      神埜聖治
    • Journal Title

      Experimental and Molecular Pathology

      Volume: 90巻 Pages: 143-148

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SNAIL induces epithelial-to-mesenchymal transition in a human pancreatic cancer cell line (BxPC3) and promotes distant metastasis and invasiveness in vivo2010

    • Author(s)
      R. Nishioka, S. Itoh, T. Gui, Z. G a i , K. Oikawa, M. Kawai, M. Tani, H. Yamaue, Y. Muragaki
    • Journal Title

      Exp. Mol. Pathol

      Volume: 89 Pages: 149-157

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Trps1 haploinsufficiency promotes renal fibrosis by increasing Arkadia expression2010

    • Author(s)
      Z. Gai, G. Zhou, T. Gui, S. Itoh, K. Oikawa, K. Uetani, Y. Muragaki
    • Journal Title

      J. Am. Soc. Nephrol

      Volume: 21 Issue: 9 Pages: 1468-1476

    • DOI

      10.1681/asn.2009121201

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deregulation of miR-92a expression is implicated in hepatocellular carcinoma development2010

    • Author(s)
      M. Shigoka, A. Tsuchida, T. Matsudo , Y. Nagakawa, H. Saito, Y. Suzuki, T. Aoki, Y. Murakami, H. Toyoda, T. Kumada, R. Bartenschlager, N. Kato, M. Ikeda, T. Takashina, M. Tanaka, R. Suzuki, K. Oikawa, M. Takanashi, M. Kuroda
    • Journal Title

      Pathol. Int

      Volume: 60 Issue: 5 Pages: 351-357

    • DOI

      10.1111/j.1440-1827.2010.02526.x

    • NAID

      10029331782

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deregulation of miR-92a expression is implicated in hepatocellular carcinoma development2010

    • Author(s)
      新後閑正敏
    • Journal Title

      Pathology International

      Volume: 60巻 Pages: 351-357

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trps1 haploinsufficiency promotes renal fibrosis by increasing Arkadia expression2010

    • Author(s)
      蓋志博
    • Journal Title

      Journal of the American Society of Nephrology

      Volume: 21巻 Pages: 1468-1476

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SNAIL induces epithelial-to-mesenchymal transition in a human pancreatic cancer cell line (BxPC3) and promotes distant metastasis and invasiveness in vivo2010

    • Author(s)
      西岡亮平
    • Journal Title

      Experimental and Molecular Pathology

      Volume: 89巻 Pages: 149-157

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Wapl regulates HP1 expression and levels of various histone H3 tail modifications2012

    • Author(s)
      及川恒輔
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      マリンメッセ福岡(福岡県)
    • Year and Date
      2012-12-12
    • Related Report
      2012 Final Research Report
  • [Presentation] 粘液型脂肪肉腫特異的キメラがんタンパクTLS-CHOPが関わる多段階発がん機構の探究2012

    • Author(s)
      及川恒輔
    • Organizer
      和歌山悪性腫瘍研究会
    • Place of Presentation
      和歌山ビッグ愛(和歌山県)
    • Year and Date
      2012-10-15
    • Related Report
      2012 Final Research Report
  • [Presentation] TLS-CHOP represses expression of the antitumor cytokine MDA-7/IL24 in myxoid liposarcoma2012

    • Author(s)
      及川恒輔
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      さっぽろ芸文館(北海道)
    • Year and Date
      2012-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] A novel oncogenic mechanism of the chimeric oncoprotein TLS-CHOP mediated by a tumor suppressor protein MDA-7/IL242011

    • Author(s)
      及川恒輔
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-12-14
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Expression of PRG4 variant C specifically functions in tumor formation and development of myxoid liposarcoma2011

    • Author(s)
      孫 玉静
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-12-14
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Gdf5/Trps1 signaling regulates Prg4 expression in the superficial cells of the articular cartilage2011

    • Author(s)
      伊藤俊治
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-12-13
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 粘液型脂肪肉腫における分子治療の可能性を探る2011

    • Author(s)
      及川恒輔
    • Organizer
      日本バイオセラピィ学会学術集会総会
    • Place of Presentation
      ダイワロイネットホテル和歌山
    • Year and Date
      2011-12-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 粘液型脂肪肉腫における分子治療の可能性を探る2011

    • Author(s)
      及川恒輔
    • Organizer
      日本バイオセラピィ学会学術集会総会
    • Place of Presentation
      ダイワロイネットホテル和歌山(和歌山県)
    • Year and Date
      2011-12-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Analysis of the novel molecular function of the cohesin-associated protein Wapl2011

    • Author(s)
      及川恒輔
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-10-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Analysis of the novel molecular function of the cohesin-associated protein Wap12011

    • Author(s)
      及川恒輔
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] コヒーシン制御タンパクWaplの新しい機能の検討2011

    • Author(s)
      及川恒輔
    • Organizer
      和歌山医学会総会
    • Place of Presentation
      和歌山県立医科大学(和歌山県)
    • Year and Date
      2011-07-10
    • Related Report
      2012 Final Research Report
  • [Presentation] 粘液型脂肪肉腫におけるPRG4の機能の検討2011

    • Author(s)
      孫 玉静
    • Organizer
      和歌山医学会総会
    • Place of Presentation
      和歌山県立医科大学(和歌山県)
    • Year and Date
      2011-07-10
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 指節間関節形成における軟骨原基表層細胞の役割2011

    • Author(s)
      伊藤俊治
    • Organizer
      和歌山医学会総会
    • Place of Presentation
      和歌山県立医科大学(和歌山県)
    • Year and Date
      2011-07-10
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] カルシウム輸送体をターゲットにするマイクロRNAはリンで誘導される2011

    • Author(s)
      桂二
    • Organizer
      和歌山医学会総会
    • Place of Presentation
      和歌山県立医科大学(和歌山県)
    • Year and Date
      2011-07-10
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] コヒーシン制御タンパクWap1の新しい機能の検討2011

    • Author(s)
      及川恒輔
    • Organizer
      和歌山医学会総会
    • Place of Presentation
      和歌山県立医科大学(和歌山県)
    • Year and Date
      2011-07-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] The PRG4 variants associated with sarcoma development have a potential to be therapeutic targets2010

    • Author(s)
      及川恒輔
    • Organizer
      日本分子生物学会年会日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Year and Date
      2010-12-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Gdf5/Trps1は関節形成軟骨細胞の分化を調節する2010

    • Author(s)
      伊藤俊治
    • Organizer
      日本分子生物学会年会日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Year and Date
      2010-12-10
    • Related Report
      2012 Final Research Report
  • [Presentation] The PRG4 variants associated with sarcoma development have a potential to be therapeutic targets2010

    • Author(s)
      及川恒輔
    • Organizer
      日本分子生物学会年会日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Gdf5/Trps1は関節形成軟骨細胞の分化を調節する2010

    • Author(s)
      伊藤俊治
    • Organizer
      日本分子生物学会年会日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 粘液型脂肪肉腫におけるキメラタンパクTLS-CHOPによる腫瘍化機構の検討2010

    • Author(s)
      及川恒輔
    • Organizer
      和歌山医学会総会
    • Place of Presentation
      和歌山県立医科大学(和歌山県)
    • Year and Date
      2010-07-11
    • Related Report
      2012 Final Research Report
  • [Presentation] Prg4はGdf5/Trps1の支配下に指節間関節形成に関与する2010

    • Author(s)
      伊藤俊治
    • Organizer
      和歌山医学会総会
    • Place of Presentation
      和歌山県立医科大学(和歌山県)
    • Year and Date
      2010-07-11
    • Related Report
      2012 Final Research Report
  • [Presentation] 腎発生期における尿管芽の枝分かれと集合管形成の調節分子機構2010

    • Author(s)
      蓋 志博
    • Organizer
      和歌山医学会総会
    • Place of Presentation
      和歌山県立医科大学(和歌山県)
    • Year and Date
      2010-07-11
    • Related Report
      2012 Final Research Report
  • [Presentation] klothoマウスにおける血管石灰化と血中リン濃度との関連性について2010

    • Author(s)
      桂二
    • Organizer
      和歌山医学会総会
    • Place of Presentation
      和歌山県立医科大学(和歌山県)
    • Year and Date
      2010-07-11
    • Related Report
      2012 Final Research Report
  • [Presentation] klothaマウスにおける血管石灰化と血中リン濃度との関連性について2010

    • Author(s)
      桂〓
    • Organizer
      和歌山医学会総会
    • Place of Presentation
      和歌山
    • Year and Date
      2010-07-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腎発生期における尿管芽の枝分かれと集合管形成の調節分子機構2010

    • Author(s)
      蓋志博
    • Organizer
      和歌山医学会総会
    • Place of Presentation
      和歌山
    • Year and Date
      2010-07-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 粘液型脂肪肉腫におけるキメラタンパクTLS-CHOPによる腫瘍化機構の検討2010

    • Author(s)
      及川恒輔
    • Organizer
      和歌山医学会総会
    • Place of Presentation
      和歌山
    • Year and Date
      2010-07-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] Prg4はGdf5/Trps1の支配下に指節間関節形成に関与する2010

    • Author(s)
      伊藤俊治
    • Organizer
      和歌山医学会総会
    • Place of Presentation
      和歌山
    • Year and Date
      2010-07-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] TLS-CHOP represses expression of the antitumor cytokine MDA-7/IL24 in myxoid liposarcoma.

    • Author(s)
      及川恒輔
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      さっぽろ芸文館(北海道)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Wapl regulates HP1 expression and levels of various histone H3 tail modifications.

    • Author(s)
      及川恒輔
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      マリンメッセ福岡(福岡県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 粘液型脂肪肉腫特異的キメラがんタンパクTLS-CHOPが関わる多段階発がん機構の探究

    • Author(s)
      及川恒輔
    • Organizer
      和歌山悪性腫瘍研究会
    • Place of Presentation
      和歌山ビッグ愛(和歌山県)
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2010-11-30   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi