Basic research for investigation of novel oncogenic mechanism by TLS-CHOP chimeric oncoprotein and its clinical application
Project/Area Number |
22590367
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Experimental pathology
|
Research Institution | Wakayama Medical University |
Principal Investigator |
OIKAWA Kosuke 和歌山県立医科大学, 医学部, 講師 (70348803)
|
Co-Investigator(Kenkyū-buntansha) |
MURAGAKI Yasuteru 和歌山県立医科大学, 医学部, 教授 (40190904)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 腫瘍 / キメラ遺伝子 / TLSーCHOP / 粘液型脂肪肉腫 / TLS-CHOP |
Research Abstract |
The TLS-CHOP fusion gene derived from chromosomal translocation is myxoid liposarcoma-specific oncogene. However, its oncogenesis mechanism and functions in tumor cells are still unclear. In this study, we have revealed that TLS-CHOP represses an anticancer cytokine MDA-7/IL-24 expression, and represses miR-486 that targets a tumor cell growth and metastasis activator PAI-1 In addition, a novel molecular pathway that induces expression of a tumorigenesis-related protein PRG4 has been suggested.
|
Report
(4 results)
Research Products
(46 results)
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[Journal Article] TLS-CHOP represses miR-486 expression, inducing upregulation of a metastasis regulator PAI-1 in human myxoid liposarcoma2012
Author(s)
N. Borjigin, S. Ohno, W. Wu, M. Tanaka, R. Suzuki, K. Fujita, M. Takanashi, K. Oikawa, T. Goto, T. Motoi, T. Kosaka, K. Yamamoto, M. Kuroda
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Journal Title
Biochem. Biophys. Res. Commun
Volume: 427
Issue: 2
Pages: 355-360
DOI
Related Report
Peer Reviewed
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[Journal Article] Deregulation of miR-92a expression is implicated in hepatocellular carcinoma development2010
Author(s)
M. Shigoka, A. Tsuchida, T. Matsudo , Y. Nagakawa, H. Saito, Y. Suzuki, T. Aoki, Y. Murakami, H. Toyoda, T. Kumada, R. Bartenschlager, N. Kato, M. Ikeda, T. Takashina, M. Tanaka, R. Suzuki, K. Oikawa, M. Takanashi, M. Kuroda
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Journal Title
Pathol. Int
Volume: 60
Issue: 5
Pages: 351-357
DOI
NAID
Related Report
Peer Reviewed
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