Analysis of microRNA function on heart and smooth muscles and itsanti-tumor effect using genetically modified mice
| Project/Area Number |
22590369
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Chubu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ICHIHARA Masatoshi 中部大学, 生命健康科学部, 教授 (00314013)
UEYAMA Tomomi 京都府立医科大学, 医学系研究科, 講師 (80379388)
NAKAYAMA Shinsuke 名古屋大学, 医学系研究科, 准教授 (30192230)
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| Co-Investigator(Renkei-kenkyūsha) |
OUCHI Yasuo 中部大学, 実験動物教育研究センター, 助教 (70553858)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | マイクロ RNA / トランスジェニックマウス / 癌 / 拡張型心筋症 / マイクロＲＮＡ / アンジオテンシン変換酵素 / マイクロRNA / 大腸癌 / c-Myc / p68/p72 / 心不全 / 心筋細胞 |
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| Research Abstract |
Although accumulating evidence has shown that microRNAs are involved in many human diseases, the molecular mechanisms are still unknown. In this project, we reveal that strong expression of certain microRNAs suppresses the intestine tumor development in the model mice of familial adenomatous polyposis and that cooperation of miRNAs plays pivotal roles in inhibiting protooncogene expression. We further show that key components for biogenesis of a subset of tumor suppressor microRNAs are downregulated in the transgenic tumors. These data indicate the complicated feedback inhibition between micoRNAs and molecules for their biogenesis. This project also demonstrates that their strong expression in mouse heart inducescardiomyopathy, partially clarifying its molecular mechanisms.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Forced Expression of miR-143 Represses ERK5/c-Myc and p68/p72 Signaling in Concert with miR-145 in Gut Tumors of ApcMin Mice.2012
Author(s)
Takaoka Y., Shimizu Y., Hasegawa H., Ouchi Y., Qiao S., Nagahara M., Ichihara M., Lee J.D., Adachi K., Hamaguchi M., Iwamoto T.
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Journal Title
Related Report
Peer Reviewed
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