| Project/Area Number |
22590370
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
|
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
KUBO Shuji 兵庫医科大学, 医学部, 准教授 (10441320)
|
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| Co-Investigator(Kenkyū-buntansha) |
OKAMURA Haruki 兵庫医科大学, 医学部, 教授 (60111043)
TERADA Nobuyuki 兵庫医科大学, 医学部, 教授 (50150339)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
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| Keywords | 腫瘍 / 悪性中皮腫 / 遺伝子治療 / 癌 / ウイルス / 分子イメージング / 自殺遺伝子療法 / 癌遺伝子治療 / 腫瘍溶解アデノウイルス |
|---|
| Research Abstract |
Our new oncolytic adenovirus, in which adenoviral replication and HSV-TK suicide gene expression was transcriptional regulated by tumor-specific midkine promoter, achieved:1) tumor-specific lytic spread of the virus, 2) anti-tumor effect in subcutaneous, intrathoracic, and intraperitoneal mesothelioma mouse models, and 3) enhanced anti-tumor effect by suicide gene activation. The midkine-promoter regulated oncolytic virus represents a promising general strategy for oncolytic virotherapy of cancers withupregulated midkine expression, including malignant mesothelioma.
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