| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Marked elevation of OPNa expression was observed in tumor tissues of chemically-induced colon carcinogenesis model in rats and mice and of pancreatic carcinogenesis models in hamsters and mice. Effect of OPN deficiency on colon carcinogenesis was not evident, but pancreatic cancer incidence and multiplicity were decreased by OPN deficiency in mouse pancreatic carcinogenesis model. The results suggest that OPN is partly involved in cancer development and invasion, and could be a target for cancer prevention.
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