| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Activation-induced cytidine deaminase-deficient (AID-/-) mice, lacking the ability to switch IgM to other isotypes, required much longer period to expel S.venezuelensis than wild-type (WT) mice. Adoptive transfers of immune sera from S. venezuelensis-infected mice restored AID-/- mice to promptly expelled S.venezuelensis. Immune serum-derived IgG and IgE induced worm expulsion via Fc γ receptor III (FcγRIII) and Fc ε receptor I (FcεRI), respectively. IgG and IgE played redundant roles but acted in concert to promote S.venezuelensis expulsion. My findings also suggest that mast cells are cellular targets of IgG and IgE.
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