Function and biosynthetic machinary of complex N-glycans expressing in Trypanosoma brucei
| Project/Area Number |
22590385
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Matsuyama University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | アフリカ睡眠病 / 糖転移酵素 / 無細胞タンパク質合成 / 寄生原虫 / Trypanosoma brucei |
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| Research Abstract |
Trypanosoma brucei, a causative agent of African sleeping sickness, expresses complex type N-linked glycans which are supposed to have critical roles for its growth. We established thee strains of gene knock-out mutants and identified two genes that were involved in the synthesis of complex type N-linked glycans. Analysis of the strains showed the terminal structures of the glycans were not critical for the normal growth of the parasite.
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Report
(4 results)
Research Products
(8 results)
