| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
Trypanosoma brucei, a causative agent of African sleeping sickness, expresses complex type N-linked glycans which are supposed to have critical roles for its growth. We established thee strains of gene knock-out mutants and identified two genes that were involved in the synthesis of complex type N-linked glycans. Analysis of the strains showed the terminal structures of the glycans were not critical for the normal growth of the parasite.
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