| Project/Area Number |
22590386
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
OSADA Yoshio 産業医科大学, 医学部, 准教授 (80282515)
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| Co-Investigator(Kenkyū-buntansha) |
KURODA Etsushi 大阪大学, 免疫学フロンティア研究センター, 准教授 (10299604)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAE Susumu 東京大学, 医科学研究所, 准教授 (60450409)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 免疫修飾 / 感染症 / 炎症 / 寄生虫 / 自己免疫疾患 / 糖尿病 / サイトカイン / 住血吸虫 / 関節炎 |
|---|
| Research Abstract |
We examined suppressive effects of Sohistosozzia mansoni infection on treptozotocin (STZ)-induced type l diabetes and spontaneous arthritis in IL-1 receptor antagonist-deficient mice. Schistosome infection significantly supPressed hyperglycemia induced by STZ. In the infected mice, pancreatic lymph node expressions of ・-cell toxic mediators were down-regulated in the infected mice. Th2 cytokines were dispensable for this anti-diabetic effect. Schistosome infection also suppressed hind paw edema in the spontaneous arthritis.
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