Study on schistosome's suppressive mechanisms against Th17-type inflammation
Project/Area Number |
22590386
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Parasitology (including Sanitary zoology)
|
Research Institution | University of Occupational and Environmental Health, Japan |
Principal Investigator |
OSADA Yoshio 産業医科大学, 医学部, 准教授 (80282515)
|
Co-Investigator(Kenkyū-buntansha) |
KURODA Etsushi 大阪大学, 免疫学フロンティア研究センター, 准教授 (10299604)
|
Co-Investigator(Renkei-kenkyūsha) |
NAKAE Susumu 東京大学, 医科学研究所, 准教授 (60450409)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 免疫修飾 / 感染症 / 炎症 / 寄生虫 / 自己免疫疾患 / 糖尿病 / サイトカイン / 住血吸虫 / 関節炎 |
Research Abstract |
We examined suppressive effects of Sohistosozzia mansoni infection on treptozotocin (STZ)-induced type l diabetes and spontaneous arthritis in IL-1 receptor antagonist-deficient mice. Schistosome infection significantly supPressed hyperglycemia induced by STZ. In the infected mice, pancreatic lymph node expressions of ・-cell toxic mediators were down-regulated in the infected mice. Th2 cytokines were dispensable for this anti-diabetic effect. Schistosome infection also suppressed hind paw edema in the spontaneous arthritis.
|
Report
(4 results)
Research Products
(32 results)
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[Journal Article] Origin of a novel protein-coding gene family with similar signal sequence in Schistosoma japonicum2012
Author(s)
Mbanefo EC, Chuanxin Y, Kikuchi M, Shuaibu MN, Boamah D, Kirinoki M, Hayashi N, Chigusa Y, Osada Y, Hamano S, Hirayama K
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Journal Title
BMC Genomics
Volume: 13
Issue: 1
Pages: 260-260
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Cerebral schistosomiasis due to Schistosoma haematobium confirmed by PCR analysis of brain specimen2011
Author(s)
Imai K, Koibuchi T, Kumagai T, Maeda T, Osada Y, Ohta N, Koga M, Nakamura H, Miura T, Iwamoto A, Fujii T
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Journal Title
Journal of Clinical Microbiology
Volume: 49
Issue: 10
Pages: 3703-6
DOI
Related Report
Peer Reviewed
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