Mechanisms of intercellular transduction of the suppressor signals through cell-to-cell contact from mycobacterial infection-induced suppressor macrophages to target T cells
| Project/Area Number |
22590392
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Yasuda Women's University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TOMIOKA Haruaki 島根大学, 医学部, 教授 (40034045)
SANO Chiaki 島根大学, 医学部, 准教授 (70325059)
TATANO Yutaka 島根大学, 医学部, 助教 (70432614)
KANEHIRO Yuichi 島根大学, 医学部, 助教 (60609197)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 感染免疫 / 難治性抗酸菌感染症 / 抗酸菌感染症 / 免疫抑制性マクロファージ / Ｔ細胞 / シグナル伝達 / アルドース還元酵素 / T細胞 / 感染症 / 抗酸菌 / マクロファージ |
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| Research Abstract |
In this study, we found that suppressor macrophages induced tyrosine dephosphorylation of aldose reductase (AR) in target T cells. In addition, some proteins in T cell lysate that interacted with AR in vitro were observed.
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Report
(4 results)
Research Products
(100 results)
