Pathogenic changes of pathogenic bacteriaby catecholamine
| Project/Area Number |
22590393
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | The University of Tokushima |
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Principal Investigator |
TAKAHASHI Akira 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (90304047)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 腸炎ビブリオ / カテコールアミン / 病原性 / ノルエピネフリン / 病原性活性化機構 |
|---|
| Research Abstract |
Catecholamine, including norepinephrine (NE), has been known as precipitating factor in bacterial infection. The aim of this study was to clarify the pathogenic activation mechanism of pathogenic bacteria that cause the catecholamine, to help infectious diseases treatment.
In this study, we analyzed using Vibrio parahaemolyticushave been studying the applicant is consistently. V.parahaemolyticusinfection can be thought of as an exemplary model of intestinal bacterial infections in general. We searched for the presence of receptors for NE on the surface in V.parahaemolyticus. And we analyzedof the regulatory mechanism and expression pathogenic gene by the NE furtherin V.parahaemolyticus. .
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Vbrio parahaemolyticusinfection induces modulation of IL-8 secretion through dual pathway via VP1680.2011
Author(s)
Shimohata T., Nakano M., Lian X., Shigeyama T., Iba H., Hamamoto A., Yoshida M., Harada N., Yamato M., Mawatari K., Tamaki T., Nakaya Y., and Takahashi A.
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Journal Title
Journal of Infectious Diseases
Volume: 203
Pages: 537-544
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