The approach of synthetic steroid ceragenin to curative medicine for infectious diseases
| Project/Area Number |
22590397
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISOGAI Emiko 東北大学, 大学院農学研究科, 教授 (80113570)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 感染症 / 微生物 / 抗菌 / CSA / Ceragenin / 抗菌ステロイド / 抗菌タンパク / 感染防御 / ＣＳＡ |
|---|
| Research Abstract |
Ceragenin (CSA) is the antibacterial material which has a steroid ring. CSA covered and mixed to a dental material. It controlled to bacterial biofilm formation on those surfaces and inhibited the bacterial growth in liquid by exuding in culture solution. Moreover, a bacterial resistant was not induced, even if staphylococcus was cultivated repeatedly in low-concentration of CSA. CSA showed the antitumor activity by inducing apoptosis to cancer cells.
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Report
(5 results)
Research Products
(27 results)
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[Journal Article] Detection of virulence genes of Escherichia coli and Salmonella spp. from fecal samples of Kafue lechwe (Kobus leche kafuensis) and pastoral cattle in the interface areas of Zambia2013
Author(s)
Kuroda K., Suzuki R., Ihara K., Miyagi H., Watanabe H., Sato K., Mudenda B. H., Mubita C., Isogai N., Mulenga E., Moonga L., Isogai H., Fukuda T., Yoneyama H., and Isogai E.
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Journal Title
African Journal of Microbiology Research
Volume: Vol. 7(6)
Pages: 504-508
Related Report
Peer Reviewed
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[Presentation] Antimicrobial activity of a bovine myeloid antimicrobial pepetide (BMAP-28) against methicillin- susceptible and methicillin-resistant Staphylococcus aureus and prediction of the structure of BMAP-28 by homology modeling2011
Author(s)
Takagi S, Saito T, Ohmura T, Isogai H, Yoneyama H, Ando T, Bai L, Fukuda T, Kato Y, Nakai Y, Isogai E
Organizer
Internatioal Union of Microbiological Societies 2011 Congress
Place of Presentation
札幌
Year and Date
2011-09-06
Related Report
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[Presentation] Antimicrobial activity of a bovine myeloid antimicrobial pepetide (BMAP-28)against methicillin-susceptible and methicillin-resistant Staphylococcus aureus and prediction of the structure of BMAP-28 by homology modeling2011
Author(s)
Takagi S, Saito T, Ohmura T, Isogai H, Yoneyama H, Ando T, Bai L, Fukuda T, Kato Y, Nakai Y, Isogai E
Organizer
Internatioal Union of Microbiological Societies 2011 Congress
Place of Presentation
Sapporo
Year and Date
2011-09-06
Related Report
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