| Project/Area Number |
22590401
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Josai International University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHUCHI Nozomi 城西国際大学, 環境社会学部, 助教 (20398556)
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| Co-Investigator(Renkei-kenkyūsha) |
TANAKA Nobutada 昭和大学, 薬学部, 准教授 (00286866)
HOSHINO Chuji 千葉大学, 薬学研究院, 准教授 (90257220)
BONOMO Robert Louis Stokes Cleveland Department of Veterans Affairs, オハイオ州、アメリカ合衆国, Professor
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 感染症 / 抗生物質 / 酵素 / 蛋白質 / 構造生物学 / β-ラクタマーゼ / X線結晶解析 / 薬剤耐性 / タンパク質 |
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| Research Abstract |
Carbapenems are one of the most important antibiotics and are used worldwide as "Last Resort". We studied four subjects, which are the inhibition mechanisms of carbapenems to beta-lactamases on the basis of Xray crystallography, as listed below. (1) Carbapenems inhibition mechanism for class C beta-lactamases. (2) Crystal structures of the PenA beta-lactamases from Burkholderia cepacia(PenI) and Burkholderia pseudomallei(PenA). (3) Crystal structure of PenA carbapenemase-avibactam complex. (4) Inhibitor screening of class B beta-lactamases.
We are showing the overview of the research with crystal structures.
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