RBM15-mediated mRNA export
Project/Area Number |
22590418
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Virology
|
Research Institution | Nagoya City University |
Principal Investigator |
URANISHI Hiroaki 名古屋市立大学, 大学院・医学研究科, 研究員 (40363923)
|
Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Takashi 名古屋市立大学, 大学院・医学研究科, 教授 (40146600)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | RBM15 / mRNA 輸送 / NXF1 / mRNA輸送 / 転写後調節 / ウイルス |
Research Abstract |
We report that RBM15 binds to ORF57 and participates in ORF57-enhanced expression of KSHV ORF59. RBM15 binds to NXF1 via its SPOC domain and promotes mRNA association to the NXF1 export pathway. Thus RBM15 is considered to be a crucial factor for mRNA export as a component of the NXF1 pathway.
|
Report
(4 results)
Research Products
(7 results)