Characterization of cell culture-generated hepatitis E virus particles:evaluation of neutralizing antibodies-inducing ability as the material of inactivated vaccineproduction
Project/Area Number |
22590419
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Virology
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Research Institution | Jichi Medical University |
Principal Investigator |
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | E型肝炎ウイルス / ワクチン / 中和抗体 / 培養細胞 |
Research Abstract |
HEV particles generated in culture supernatant of cell-culturesystems of PLC/PRF/5, A549, HepG2/C3A, Li-7, Huh7 and Caco-2 cells were found to beassociated with envelope-like membrane, and HEV capsid antigen which carryneutralization epitope was buried by
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Hepatitis Evirus (HEV) strains in serum samples canreplicate efficiently in cultured cells despitethe coexistence of HEV antibodies:characterization of HEV virions in bloodcirculation.2010
Author(s)
Takahashi M, Tanaka T, Takahashi H,Hoshino Y, Nagashima S, Jirintai, Mizuo H,Yazaki Y, Takagi T, Azuma M, Kusano E,Isoda N, Sugano K, Okamoto H
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Journal Title
J Clin Microbiol
Volume: 48
Issue: 4
Pages: 1112-1125
DOI
Related Report
Peer Reviewed
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