• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analysis of the regulation of plasmacytoid dendritic cells by the rece ptors and novel molecules.

Research Project

Project/Area Number 22590431
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Immunology
Research InstitutionKanazawa Medical University

Principal Investigator

NAKAMURA Akira  金沢医科大学, 医学部, 教授 (20344723)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords免疫学 / 感染症 / 免疫制御受容体 / プラズマサイトイド樹状細胞
Research Abstract

Plasmacytoid dendritic cells (pDCs) produce type I interferons (IFNs) in response to viral nucleic acids to exert antiviral immunity. In the presentstudy, we showed that an inhibitory major histocompatibility complex class I receptor,paired immunoglobulin-like receptor (PIR)-B, suppressed TLR9-mediated IFN-α productionby inhibiting the positive feedback mechanism of IFN-α secretion.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (19 results)

All 2013 2012 2011 2010 Other

All Journal Article (11 results) (of which Peer Reviewed: 5 results) Presentation (4 results) (of which Invited: 1 results) Book (2 results) Remarks (2 results)

  • [Journal Article] Regulation of plasmacytoid dendritic cell responses by PIR-B.2012

    • Author(s)
      MitsuhashiY,NakamuraA,EndoS,TakedaK,Yabe-WadaT,NukiwaT,TakaiT(correspondenceauthor)
    • Journal Title

      Blood

      Volume: 120 Issue: 16 Pages: 3256-3259

    • DOI

      10.1182/blood-2012-03-419093

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Runx1 deficiency in CD4+ T cells causes fatal autoimmune inflammatory lung disease due to spontaneous hyperactivation of cells.2012

    • Author(s)
      Wong WF, Tazawa R, (15名略)Nakata K, Takai T, Satake M.
    • Journal Title

      J Immunol.

      Volume: 188(11) Issue: 11 Pages: 5408-5420

    • DOI

      10.4049/jimmunol.1102991

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential but competitive binding of Nogo and MHCI to PIR-B provides an inhibition of cells2011

    • Author(s)
      Matsushita H, et al
    • Journal Title

      J.Biol.Chem.

      Volume: 286(29) Issue: 29 Pages: 25739-25747

    • DOI

      10.1074/jbc.m110.157859

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional activation of the Pirb gene in B cells by PU.1 and Runx32011

    • Author(s)
      Arita K, et al
    • Journal Title

      J.Immunol.

      Volume: 186(12) Issue: 12 Pages: 7050-7059

    • DOI

      10.4049/jimmunol.1001302

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of PIR-B in autoimmune glomerulo-nephritis.2011

    • Author(s)
      Takai T,Nakamura A,Endo S.
    • Journal Title

      JournalofBiomedicineandBiotechnology

      Volume: 275302 Issue: 1 Pages: 275302-275302

    • DOI

      10.1155/2011/275302

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Paired immunoglobulin-like receptor(PIR)の自己免疫疾患における役割2011

    • Author(s)
      中村晃、高井俊行
    • Journal Title

      リウマチ科

      Volume: 46号 Pages: 184-189

    • URL

      http://www.kahyo.com/item/R201108-462

    • Related Report
      2012 Final Research Report
  • [Journal Article] 免疫抑制性レセプターPIR-Bによるアレルギー制御2010

    • Author(s)
      北口公司、中村晃、高井俊行
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 5号 Pages: 540-545

    • URL

      http://www.kahyo.com/item/M201011-545

    • Related Report
      2012 Final Research Report
  • [Journal Article] PIR-B、CD22、CD72からのシグナルによるB細胞活性化抑制の機序2010

    • Author(s)
      中村晃、高井俊行
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 1号 Pages: 35-43

    • URL

      http://www.kahyo.com/item/M201007-541

    • Related Report
      2012 Final Research Report
  • [Journal Article] 炎症とDAP12/DAP10/FcRγ2010

    • Author(s)
      中村晃、乾匡範,、高井俊行
    • Journal Title

      感染・炎症・免疫

      Volume: 2号 Pages: 120-129

    • URL

      http://www.torii.co.jp/index.html

    • Related Report
      2012 Final Research Report
  • [Journal Article] PIR-B、CD22、CD72からのシグナルによるB細胞活性化抑制の機序2010

    • Author(s)
      中村晃
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 54 Pages: 35-43

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 炎症とDAP12/DAP10/FcRγ2010

    • Author(s)
      中村晃
    • Journal Title

      感染・炎症・免疫

      Volume: 40 Pages: 120-129

    • Related Report
      2010 Annual Research Report
  • [Presentation] 発症機序から考えるアレルギー疾患の抗体治療2011

    • Author(s)
      中村晃
    • Organizer
      日本内科学会北陸地方会第54回生涯教育講演
    • Place of Presentation
      金沢医科大学(石川県)
    • Year and Date
      2011-09-11
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] A regulatory role of PIR-B in plasmacytoid dendritic cells2010

    • Author(s)
      Yoshiya Mitsuhashi,Akira Nakamura,ToshihiroN ukiwa,Toshiyuki Takai
    • Organizer
      第14回国際免疫学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-08-26
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] Kinetic analysis of the association between PIR-B and its related molecules in B cells2010

    • Author(s)
      Yuzuru Sakamoto,Yuko Watanabe,Akira Nakamura,Toshiyuki Takai
    • Organizer
      第14回国際免疫学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-08-25
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] Regulation of TLR9-mediated cellular activation by PIR-B

    • Author(s)
      中村 晃
    • Organizer
      金沢医科大学・華中科技大学同済医学院 第3回日中学術講演会
    • Place of Presentation
      金沢医科大学(石川県)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] 標準免疫学2013

    • Author(s)
      中村晃、高井俊行
    • Publisher
      炎症のメカニズム
    • Related Report
      2012 Final Research Report
  • [Book] 標準免疫学(谷口克監修、宮坂昌之、小安重夫編集)2013

    • Author(s)
      中村 晃
    • Total Pages
      14
    • Publisher
      医学書院
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.kanazawa-med.ac.jp/-serol/

    • Related Report
      2012 Final Research Report
  • [Remarks] 金沢医科大学 免疫学 業績

    • URL

      http://www.kanazawa-med.ac.jp/~serol/index.html

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi