Analysis of the regulation of plasmacytoid dendritic cells by the rece ptors and novel molecules.
| Project/Area Number |
22590431
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 免疫学 / 感染症 / 免疫制御受容体 / プラズマサイトイド樹状細胞 |
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| Research Abstract |
Plasmacytoid dendritic cells (pDCs) produce type I interferons (IFNs) in response to viral nucleic acids to exert antiviral immunity. In the presentstudy, we showed that an inhibitory major histocompatibility complex class I receptor,paired immunoglobulin-like receptor (PIR)-B, suppressed TLR9-mediated IFN-α productionby inhibiting the positive feedback mechanism of IFN-α secretion.
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Report
(4 results)
Research Products
(19 results)
