Analysis of the regulation of plasmacytoid dendritic cells by the rece ptors and novel molecules.

• Project/Area Number: 22590431
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Immunology
• Research Institution: Kanazawa Medical University
• Principal Investigator: NAKAMURA Akira 金沢医科大学, 医学部, 教授 (20344723)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 免疫学 / 感染症 / 免疫制御受容体 / プラズマサイトイド樹状細胞

Research Abstract

Plasmacytoid dendritic cells (pDCs) produce type I interferons (IFNs) in response to viral nucleic acids to exert antiviral immunity. In the presentstudy, we showed that an inhibitory major histocompatibility complex class I receptor,paired immunoglobulin-like receptor (PIR)-B, suppressed TLR9-mediated IFN-α productionby inhibiting the positive feedback mechanism of IFN-α secretion.

Research Products

• [Journal Article] Regulation of plasmacytoid dendritic cell responses by PIR-B. (2012)
  • Author(s): MitsuhashiY,NakamuraA,EndoS,TakedaK,Yabe-WadaT,NukiwaT,TakaiT(correspondenceauthor)
  • Journal Title: Blood Volume: 120 Issue: 16 Pages: 3256-3259
  • DOI: 10.1182/blood-2012-03-419093
  • Peer Reviewed
• [Journal Article] Runx1 deficiency in CD4+ T cells causes fatal autoimmune inflammatory lung disease due to spontaneous hyperactivation of cells. (2012)
  • Author(s): Wong WF, Tazawa R, （15名略）Nakata K, Takai T, Satake M.
  • Journal Title: J Immunol. Volume: 188(11) Issue: 11 Pages: 5408-5420
  • DOI: 10.4049/jimmunol.1102991
  • Peer Reviewed
• [Journal Article] Differential but competitive binding of Nogo and MHCI to PIR-B provides an inhibition of cells (2011)
  • Author(s): Matsushita H, et al
  • Journal Title: J.Biol.Chem. Volume: 286(29) Issue: 29 Pages: 25739-25747
  • DOI: 10.1074/jbc.m110.157859
  • Peer Reviewed
• [Journal Article] Transcriptional activation of the Pirb gene in B cells by PU.1 and Runx3 (2011)
  • Author(s): Arita K, et al
  • Journal Title: J.Immunol. Volume: 186(12) Issue: 12 Pages: 7050-7059
  • DOI: 10.4049/jimmunol.1001302
  • Peer Reviewed
• [Journal Article] Role of PIR-B in autoimmune glomerulo-nephritis. (2011)
  • Author(s): Takai T,Nakamura A,Endo S.
  • Journal Title: JournalofBiomedicineandBiotechnology Volume: 275302 Issue: 1 Pages: 275302-275302
  • DOI: 10.1155/2011/275302
  • Peer Reviewed
• [Journal Article] Paired immunoglobulin-like receptor(PIR)の自己免疫疾患における役割 (2011)
  • Author(s): 中村晃、高井俊行
  • Journal Title: リウマチ科 Volume: 46号 Pages: 184-189
  • URL: http://www.kahyo.com/item/R201108-462
• [Journal Article] 免疫抑制性レセプターPIR-Bによるアレルギー制御 (2010)
  • Author(s): 北口公司、中村晃、高井俊行
  • Journal Title: 臨床免疫・アレルギー科 Volume: 5号 Pages: 540-545
  • URL: http://www.kahyo.com/item/M201011-545
• [Journal Article] PIR-B、CD22、CD72からのシグナルによるB細胞活性化抑制の機序 (2010)
  • Author(s): 中村晃、高井俊行
  • Journal Title: 臨床免疫・アレルギー科 Volume: 1号 Pages: 35-43
  • URL: http://www.kahyo.com/item/M201007-541
• [Journal Article] 炎症とDAP12/DAP10/FcRγ (2010)
  • Author(s): 中村晃、乾匡範,、高井俊行
  • Journal Title: 感染・炎症・免疫 Volume: 2号 Pages: 120-129
  • URL: http://www.torii.co.jp/index.html
• [Journal Article] PIR-B、CD22、CD72からのシグナルによるB細胞活性化抑制の機序 (2010)
  • Author(s): 中村晃
  • Journal Title: 臨床免疫・アレルギー科 Volume: 54 Pages: 35-43
• [Journal Article] 炎症とDAP12/DAP10/FcRγ (2010)
  • Author(s): 中村晃
  • Journal Title: 感染・炎症・免疫 Volume: 40 Pages: 120-129
• [Presentation] 発症機序から考えるアレルギー疾患の抗体治療 (2011)
  • Author(s): 中村晃
  • Organizer: 日本内科学会北陸地方会第54回生涯教育講演
  • Place of Presentation: 金沢医科大学(石川県)
  • Year and Date: 2011-09-11
• [Presentation] A regulatory role of PIR-B in plasmacytoid dendritic cells (2010)
  • Author(s): Yoshiya Mitsuhashi,Akira Nakamura,ToshihiroN ukiwa,Toshiyuki Takai
  • Organizer: 第14回国際免疫学会
  • Place of Presentation: 神戸
  • Year and Date: 2010-08-26
• [Presentation] Kinetic analysis of the association between PIR-B and its related molecules in B cells (2010)
  • Author(s): Yuzuru Sakamoto,Yuko Watanabe,Akira Nakamura,Toshiyuki Takai
  • Organizer: 第14回国際免疫学会
  • Place of Presentation: 神戸
  • Year and Date: 2010-08-25
• [Presentation] Regulation of TLR9-mediated cellular activation by PIR-B
  • Author(s): 中村 晃
  • Organizer: 金沢医科大学・華中科技大学同済医学院 第３回日中学術講演会
  • Place of Presentation: 金沢医科大学（石川県）
  • Invited
• [Book] 標準免疫学 (2013)
  • Author(s): 中村晃、高井俊行
  • Publisher: 炎症のメカニズム
• [Book] 標準免疫学（谷口克監修、宮坂昌之、小安重夫編集） (2013)
  • Author(s): 中村 晃
  • Total Pages: 14
  • Publisher: 医学書院
• [Remarks]
  • URL: http://www.kanazawa-med.ac.jp/-serol/
• [Remarks] 金沢医科大学 免疫学 業績
  • URL: http://www.kanazawa-med.ac.jp/~serol/index.html