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Control of leukocyte migration to inflamed sites and its application to the treatment of refractory inflammatory diseases

Research Project

Project/Area Number 22590433
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Immunology
Research InstitutionShiga University of Medical Science (2012)
Kyoto University (2010-2011)

Principal Investigator

HIRATA Takako  滋賀医科大学, 医学部, 教授 (00346199)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords炎症 / アレルギー / 好中球 / リンパ球 / セレクチン / ケモカイン / ERMタンパク質 / モエシン / 白血球 / ローリング / セレクチンリガンド
Research Abstract

Leukocyte migration to inflamed sites is an essential process that occurs during inflammation and immune responses. Control of this process provides a new approach to the treatment of a variety of refractory, inflammatory diseases. In this research project, we identified moesin, an ERM family member, as a molecule that regulates leukocyte migration. We clarified that moesin regulates neutrophil and lymphocytetrafficking in vivo.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (18 results)

All 2013 2012 2011 2010 Other

All Journal Article (11 results) (of which Peer Reviewed: 7 results) Presentation (4 results) Remarks (3 results)

  • [Journal Article] Prostaglandin E2promotes Th1 differentiation via synergistic amplification of IL-12 signaling by cAMP and PI3-kinase.2013

    • Author(s)
      Yao, C., Hirata, T., Soontrapa K., Ma, X., Takemori, H., and Narumiya, S
    • Journal Title

      Nat. Commun

      Volume: 4 Issue: 1 Pages: 1685-1685

    • DOI

      10.1038/ncomms2684

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prostanoids as regulators of innate and adaptive immunity2012

    • Author(s)
      Hirata, T.and Narumiya, S
    • Journal Title

      Adv. Immunol.

      Volume: 116 Pages: 143-174

    • DOI

      10.1016/b978-0-12-394300-2.00005-3

    • ISBN
      9780123943002
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] Moesin-deficient mice reveal a non-redundant role for moesin in lymphocyte homeostasis2012

    • Author(s)
      Hirata T., et al
    • Journal Title

      Int Immunol.

      Volume: 24 Issue: 11 Pages: 705

    • DOI

      10.1093/intimm/dxs077

    • URL

      https://pure.teikyo.jp/en/publications/a111f7cf-bfc5-40a3-9022-8915b8375687

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prostanoid receptors2011

    • Author(s)
      Takako Hirata
    • Journal Title

      Chemical Reviews

      Volume: 111 Issue: 10 Pages: 6209-6230

    • DOI

      10.1021/cr200010h

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GPR40 agonist GW9508 suppresses CCL5, CCL17 and CXCL10 induction in keratinocytes and attenuates cutaneous immune inflammation2011

    • Author(s)
      Tomoko Fujita
    • Journal Title

      Journal of Investigative Dermatology

      Volume: 131 Issue: 8 Pages: 1660-1667

    • DOI

      10.1038/jid.2011.123

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin E2-prostoglandin E receptor subtype 4 (EP4) signaling mediates UV irradiation-induced systemic immunosuppression2011

    • Author(s)
      Kitipong Soontrapa, Tetsuya Honda, Daiji Sakata, Chengcan Yao, Takako Hirata, Shohei Hori, Toshiyuki Matsuoka, Yoshihiro Kita, Takao Shimizu, Kenji Kabashima, Shuh Narumiya
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 108 Issue: 16 Pages: 668-667

    • DOI

      10.1073/pnas.1018625108

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] プロスタノイドによる免疫系・神経系調節.2010

    • Author(s)
      平田 多佳子, 古屋敷 智之
    • Journal Title

      実験医学

      Volume: 28 Pages: 3386-3394

    • Related Report
      2012 Final Research Report
  • [Journal Article] シアロムチンファミリー. 広範囲 血液・尿化学検査 免疫学的検査[第7版]2010

    • Author(s)
      平田 多佳子
    • Journal Title

      日本臨床社

      Pages: 176-179

    • Related Report
      2012 Final Research Report
  • [Journal Article] プロスタノイドによる免疫系・神経系調節2010

    • Author(s)
      平田多佳子
    • Journal Title

      実験医学

      Volume: 28 Pages: 3386-3394

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Prostaglandin E2-EP4 signaling mediates UV irradiation-induced systemic immunosuppression by regulating epidermal RANKL expression

    • Author(s)
      Kitipong Soontrapa
    • Journal Title

      Proceedings of National Academy of Science, U.S.A.

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GPR40 agonist GW9508 suppresses CCL5, CCL17 and CXCL10 induction in keratinocytes and attenuates cutaneous immune inflammation

    • Author(s)
      Tomoko Fujita
    • Journal Title

      Journal of Investigative Dermatology

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] The ERM protein moesin regulates lymphocyte homeostasis by controlling lymphocyte egress from lymphoid organs2011

    • Author(s)
      Hirata, T.
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-29
    • Related Report
      2012 Final Research Report
  • [Presentation] Regulation of S1P responsiveness by the ERM protein moesin.2011

    • Author(s)
      Nomachi, A
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-29
    • Related Report
      2012 Final Research Report
  • [Presentation] The ERM protein moesin regulates lymphocyte homeostasis by controlling lymphocyte egress from lymphoid organs2011

    • Author(s)
      Takako Hirata
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Regulation of S1P responsiveness by the ERM protein moesin2011

    • Author(s)
      Akira Nomachi
    • Organizer
      第40回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.shiga-med.ac.jp/subject/department/departments10.html

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.shiga-med.ac.jp/e_new/department/ekouza/html/012.html

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.ak.med.kyoto-u.ac.jp/group_research/hirataG.html

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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