Control of leukocyte migration to inflamed sites and its application to the treatment of refractory inflammatory diseases
Project/Area Number |
22590433
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Immunology
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Research Institution | Shiga University of Medical Science (2012) Kyoto University (2010-2011) |
Principal Investigator |
HIRATA Takako 滋賀医科大学, 医学部, 教授 (00346199)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 炎症 / アレルギー / 好中球 / リンパ球 / セレクチン / ケモカイン / ERMタンパク質 / モエシン / 白血球 / ローリング / セレクチンリガンド |
Research Abstract |
Leukocyte migration to inflamed sites is an essential process that occurs during inflammation and immune responses. Control of this process provides a new approach to the treatment of a variety of refractory, inflammatory diseases. In this research project, we identified moesin, an ERM family member, as a molecule that regulates leukocyte migration. We clarified that moesin regulates neutrophil and lymphocytetrafficking in vivo.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Prostaglandin E2promotes Th1 differentiation via synergistic amplification of IL-12 signaling by cAMP and PI3-kinase.2013
Author(s)
Yao, C., Hirata, T., Soontrapa K., Ma, X., Takemori, H., and Narumiya, S
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Journal Title
Nat. Commun
Volume: 4
Issue: 1
Pages: 1685-1685
DOI
Related Report
Peer Reviewed
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[Journal Article] Prostaglandin E2-prostoglandin E receptor subtype 4 (EP4) signaling mediates UV irradiation-induced systemic immunosuppression2011
Author(s)
Kitipong Soontrapa, Tetsuya Honda, Daiji Sakata, Chengcan Yao, Takako Hirata, Shohei Hori, Toshiyuki Matsuoka, Yoshihiro Kita, Takao Shimizu, Kenji Kabashima, Shuh Narumiya
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Journal Title
Proc Natl Acad Sci U S A
Volume: 108
Issue: 16
Pages: 668-667
DOI
Related Report
Peer Reviewed
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