Control of leukocyte migration to inflamed sites and its application to the treatment of refractory inflammatory diseases

• Project/Area Number: 22590433
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Immunology
• Research Institution: Shiga University of Medical Science (2012); Kyoto University (2010-2011)
• Principal Investigator: HIRATA Takako 滋賀医科大学, 医学部, 教授 (00346199)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 炎症 / アレルギー / 好中球 / リンパ球 / セレクチン / ケモカイン / ERMタンパク質 / モエシン / 白血球 / ローリング / セレクチンリガンド

Research Abstract

Leukocyte migration to inflamed sites is an essential process that occurs during inflammation and immune responses. Control of this process provides a new approach to the treatment of a variety of refractory, inflammatory diseases. In this research project, we identified moesin, an ERM family member, as a molecule that regulates leukocyte migration. We clarified that moesin regulates neutrophil and lymphocytetrafficking in vivo.

Research Products

• [Journal Article] Prostaglandin E2promotes Th1 differentiation via synergistic amplification of IL-12 signaling by cAMP and PI3-kinase. (2013)
  • Author(s): Yao, C., Hirata, T., Soontrapa K., Ma, X., Takemori, H., and Narumiya, S
  • Journal Title: Nat. Commun Volume: 4 Issue: 1 Pages: 1685-1685
  • DOI: 10.1038/ncomms2684
  • Peer Reviewed
• [Journal Article] Prostanoids as regulators of innate and adaptive immunity (2012)
  • Author(s): Hirata, T.and Narumiya, S
  • Journal Title: Adv. Immunol. Volume: 116 Pages: 143-174
  • DOI: 10.1016/b978-0-12-394300-2.00005-3
  • ISBN: 9780123943002
• [Journal Article] Moesin-deficient mice reveal a non-redundant role for moesin in lymphocyte homeostasis. (2012)
  • Author(s): Hirata T., et al
  • Journal Title: Int Immunol. Volume: 24 Issue: 11 Pages: 705-717
  • DOI: 10.1093/intimm/dxs077
  • Peer Reviewed
• [Journal Article] Prostanoid receptors (2011)
  • Author(s): Takako Hirata
  • Journal Title: Chemical Reviews Volume: 111 Issue: 10 Pages: 6209-6230
  • DOI: 10.1021/cr200010h
  • Peer Reviewed
• [Journal Article] GPR40 agonist GW9508 suppresses CCL5, CCL17 and CXCL10 induction in keratinocytes and attenuates cutaneous immune inflammation (2011)
  • Author(s): Tomoko Fujita
  • Journal Title: Journal of Investigative Dermatology Volume: 131 Issue: 8 Pages: 1660-1667
  • DOI: 10.1038/jid.2011.123
  • Peer Reviewed
• [Journal Article] Prostaglandin E2-prostoglandin E receptor subtype 4 (EP4) signaling mediates UV irradiation-induced systemic immunosuppression (2011)
  • Author(s): Kitipong Soontrapa, Tetsuya Honda, Daiji Sakata, Chengcan Yao, Takako Hirata, Shohei Hori, Toshiyuki Matsuoka, Yoshihiro Kita, Takao Shimizu, Kenji Kabashima, Shuh Narumiya
  • Journal Title: Proc Natl Acad Sci U S A Volume: 108 Issue: 16 Pages: 668-667
  • DOI: 10.1073/pnas.1018625108
  • Peer Reviewed
• [Journal Article] プロスタノイドによる免疫系・神経系調節. (2010)
  • Author(s): 平田 多佳子, 古屋敷 智之
  • Journal Title: 実験医学 Volume: 28 Pages: 3386-3394
• [Journal Article] シアロムチンファミリー. 広範囲 血液・尿化学検査 免疫学的検査[第7版] (2010)
  • Author(s): 平田 多佳子
  • Journal Title: 日本臨床社 Pages: 176-179
• [Journal Article] プロスタノイドによる免疫系・神経系調節 (2010)
  • Author(s): 平田多佳子
  • Journal Title: 実験医学 Volume: 28 Pages: 3386-3394
• [Journal Article] Prostaglandin E2-EP4 signaling mediates UV irradiation-induced systemic immunosuppression by regulating epidermal RANKL expression
  • Author(s): Kitipong Soontrapa
  • Journal Title: Proceedings of National Academy of Science, U.S.A. Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] GPR40 agonist GW9508 suppresses CCL5, CCL17 and CXCL10 induction in keratinocytes and attenuates cutaneous immune inflammation
  • Author(s): Tomoko Fujita
  • Journal Title: Journal of Investigative Dermatology Volume: (印刷中)
  • Peer Reviewed
• [Presentation] The ERM protein moesin regulates lymphocyte homeostasis by controlling lymphocyte egress from lymphoid organs (2011)
  • Author(s): Hirata, T.
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-29
• [Presentation] Regulation of S1P responsiveness by the ERM protein moesin. (2011)
  • Author(s): Nomachi, A
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-29
• [Presentation] The ERM protein moesin regulates lymphocyte homeostasis by controlling lymphocyte egress from lymphoid organs (2011)
  • Author(s): Takako Hirata
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ(千葉県)
  • Year and Date: 2011-11-29
• [Presentation] Regulation of S1P responsiveness by the ERM protein moesin (2011)
  • Author(s): Akira Nomachi
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ(千葉県)
  • Year and Date: 2011-11-29
• [Remarks]
  • URL: http://www.shiga-med.ac.jp/subject/department/departments10.html
• [Remarks]
  • URL: http://www.shiga-med.ac.jp/e_new/department/ekouza/html/012.html
• [Remarks]
  • URL: http://www.ak.med.kyoto-u.ac.jp/group_research/hirataG.html