Role of GANP-mediated hypermutation
| Project/Area Number |
22590436
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Kumamoto University |
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Principal Investigator |
MAEDA Kazuhiko 熊本大学, 大学院・生命科学研究部, 助教 (20332869)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 免疫学 / ゲノム / 遺伝子 |
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| Research Abstract |
Activation-induced cytidine deaminase (AID) is essential to thegeneration for somatic hypermutation at immunoglobulin gene locus. However, it is unclearhow cytoplasmic AID shepherds from cytoplasm to nucleus toward the IgV locus. We studiedthe role of GANP-mediated somatic hypermutation in B cells. We showed that GANP forms acomplex with AID in the cytoplasm and relocated into the nucleus. We found that GANPregulates the recruitment of AID to the immunoglobulin variable regions by modulatingtranscription and nucleosome occupancy.
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Report
(4 results)
Research Products
(42 results)
