To elucidate the roles of SOCS1 to regulate the differentiation of follicular helper T cells
Project/Area Number |
22590438
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Immunology
|
Research Institution | Keio University |
Principal Investigator |
MORITA Rimpei 慶應義塾大学, 医学部, 講師 (00362541)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | リンパ球 / 抗体産生 / SOCS1 / IL-21 / Th17 / 免疫学 / Treg / IFN-γ |
Research Abstract |
The purposes of this study are to elucidate the effects of SOCS1 on the differentiation of effecter Th cells, especially follicular helper T cells. We successfully demonstrated that immunosuppressive T cells, Treg cells turned into exFoxp3 cells with losi
|
Report
(4 results)
Research Products
(17 results)
-
-
-
-
-
-
-
-
-
[Journal Article] Human blood CXCR5+CD4+T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion.2011
Author(s)
Morita1 R, Schmitt N, Bentebibel SE, Ranganathan R, Bourdery L, Zurawski G,Foucat E, Dullaers M, Oh SK, SabzghabaeiN, Lavecchio EM, Punaro M, Pascual V,Banchereau J, Ueno H.
-
Journal Title
Immunity.
Volume: 34
Issue: 1
Pages: 108-121
DOI
Related Report
-
-
-
-
-
-
-
-