To elucidate the roles of SOCS1 to regulate the differentiation of follicular helper T cells

• Project/Area Number: 22590438
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Immunology
• Research Institution: Keio University
• Principal Investigator: MORITA Rimpei 慶應義塾大学, 医学部, 講師 (00362541)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: リンパ球 / 抗体産生 / SOCS1 / IL-21 / Th17 / 免疫学 / Treg / IFN-γ

Research Abstract

The purposes of this study are to elucidate the effects of SOCS1 on the differentiation of effecter Th cells, especially follicular helper T cells. We successfully demonstrated that immunosuppressive T cells, Treg cells turned into exFoxp3 cells with losi

Research Products

• [Journal Article] Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis. (2013)
  • Author(s): Sekiya T, Kashiwagi I, Yoshida R, Fukaya T, et al.
  • Journal Title: Nat Immunol. Volume: 14 Issue: 3 Pages: 230-237
  • DOI: 10.1038/ni.2520
  • Peer Reviewed
• [Journal Article] IL-23-Independent Induction of IL-17 from γδT Cells and Innate Lymphoid Cells Promotes Experimental Intraocular Neovascularization (2013)
  • Author(s): Hasegawa E
  • Journal Title: J Immunol Volume: 190 Issue: 4 Pages: 1778-1787
  • DOI: 10.4049/jimmunol.1202495
  • Peer Reviewed
• [Journal Article] Smad2 and Smad3 are redundantly essential for the suppression of iNOS synthesis in macrophages by regulating IRF3 and STAT1 pathways (2012)
  • Author(s): Sugiyama Yuki, 他
  • Journal Title: International Immunology Volume: 24 Issue: 4 Pages: 253-256
  • DOI: 10.1093/intimm/dxr126
  • Peer Reviewed
• [Journal Article] Low dose CP-690,550 (tofacitinib), a pan-JAK inhibitor, accelerates the onset of experimental autoimmune encephalomyelitis by potentiating Th17 differentiation (2012)
  • Author(s): Yoshida Hideyuki, 他
  • Journal Title: Biochem Biophys Res Commun Volume: 418 Issue: 2 Pages: 234-240
  • DOI: 10.1016/j.bbrc.2011.12.156
  • Peer Reviewed
• [Journal Article] Pyridone 6, a pan-JAK inhibitor, ameliorates allergic skin inflammation of NC/Nga mice via suppression of Th2 and enhancement of Th17 (2011)
  • Author(s): Ryusuke Nakagawa, 他
  • Journal Title: Journal of Immunology Volume: 187 Issue: 9 Pages: 4611-4620
  • DOI: 10.4049/jimmunol.1100649
  • Peer Reviewed
• [Journal Article] SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-{gamma} and IL-17A production. (2011)
  • Author(s): Takahashi R, Nishimoto S, Muto G, Sekiya T, Tamiya T, Kimura A, Morita R, Asakawa M, Chinen T, Yoshimura A.
  • Journal Title: J Exp Med. Volume: 208 Issue: 10 Pages: 2055-2067
  • DOI: 10.1084/jem.20110428
  • Peer Reviewed
• [Journal Article] Transcription Factor Smad-Independent T Helper 17 Cell Induction by Transforming-Growth Factor-ss Is Mediated by Suppression of Eomesodermin (2011)
  • Author(s): Kenji Ichiyama, 他
  • Journal Title: Immunity Volume: 34 Issue: 5 Pages: 741-754
  • DOI: 10.1016/j.immuni.2011.02.021
  • Peer Reviewed
• [Journal Article] The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells (2011)
  • Author(s): Sekiya, T., et al
  • Journal Title: Nature Communications Volume: 2 Issue: 1 Pages: 269-269
  • DOI: 10.1038/ncomms1272
  • Peer Reviewed
• [Journal Article] Human blood CXCR5+CD4+T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. (2011)
  • Author(s): Morita1 R, Schmitt N, Bentebibel SE, Ranganathan R, Bourdery L, Zurawski G,Foucat E, Dullaers M, Oh SK, SabzghabaeiN, Lavecchio EM, Punaro M, Pascual V,Banchereau J, Ueno H.
  • Journal Title: Immunity. Volume: 34 Issue: 1 Pages: 108-121
  • DOI: 10.1016/j.immuni.2010.12.012
• [Journal Article] 濾胞ヘルパーT細胞の分化誘導 (2011)
  • Author(s): 森田林平
  • Journal Title: 臨床免疫・アレルギー科 Volume: 56 Pages: 694-699
  • NAID: 40019145229
• [Journal Article] SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-γ and IL-17A production (2011)
  • Author(s): 高橋令子, 等
  • Journal Title: J.Exp.Med. Volume: 208 Pages: 2055-2067
  • Peer Reviewed
• [Journal Article] Human blood CXCR5^+CD4^+ T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion (2011)
  • Author(s): 森田林平, 等
  • Journal Title: Immunity Volume: 34 Pages: 108-121
  • Peer Reviewed
• [Journal Article] SOCS1 regulates type I/type II NKT cell balance by regulating IFN {gamma} signaling (2011)
  • Author(s): 橋本雅之
  • Journal Title: Int.Immunol. Volume: 23 Pages: 195-202
  • Peer Reviewed
• [Presentation] Epigenetic modification induces CD8abexpressing double-positive T cells from human blood CD4+ T cells counterparts of T follicular cells (2012)
  • Author(s): 森田林平、吉村昭彦
  • Organizer: 第41回日本免疫学会学術集会・総会
  • Place of Presentation: 神戸
• [Presentation] Epigenetic modification induces CD8-expressing double-positive T cells from human blood CD4+ T cells (2012)
  • Author(s): Morita Rimpei
  • Organizer: 日本免疫学会
  • Place of Presentation: 神戸
• [Presentation] Human blood CXCR5+ CD4+ T cells are counterparts of T follicular cells (2011)
  • Author(s): 森田林平
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ:千葉(国際シンポジウム)
  • Year and Date: 2011-11-27
• [Presentation] Human blood CXCR5+ CD4+ T cells are counterparts of T follicular cells (2011)
  • Author(s): 森田林平
  • Organizer: 第40回日本免疫学会学術集会・総会
  • Place of Presentation: 千葉