Immune regulation through dendritic cell-specific mTOR pathway
Project/Area Number |
22590439
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Immunology
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Research Institution | Kansai Medical University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
OHTANI Masashi 関西医科大学, 医学部, 助教 (20383713)
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Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | mTOR / 樹状細胞 / IL-10 / Raptor / 免疫制御 / サイトカイン |
Research Abstract |
Although several reports have suggested the involvement of mTORC1 in development and function of dendritic cells (DCs), its physiological roles remain obscure. By using mTORC1 signal-deficient mice lacking Raptor, an essential component of mTORC1 signal, specifically in DC lineage (referred to here as RaptorDC-/-), we found that impaired mTORC1 signal resulted in the suppression of IL-10 production in intestinal CD11c+CD11b+ DCs. We also found that RaptorDC-/- mice were highly susceptible to dextran sodium sulfate-induced colitis.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] HIV-1 Nef impairs multiple T-cell functions in antigen-specific immune response in mice2011
Author(s)
Fujii, H., Ato, M., Takahashi, Y., Otake, K., Hashimoto, S., Kaji, T., Tsunetsugu-Yokota, Y., Fujita, M., Adachi, A., Nakayama, T., Taniguchi, M. Koyasu, S., Takemori, T.
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Journal Title
Int.Immunol.
Volume: 23
Issue: 7
Pages: 433-441
DOI
Related Report
Peer Reviewed
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[Presentation] mTOR complex1 is critical for B cell development.2012
Author(s)
Ohtani, M., Fujii, H., Sakai, K., Hoshii, T., Watanabe, T., Koyasu, S., Hirao, A., and Matsuda, S.
Organizer
第35回日本分子生物学会年会
Place of Presentation
福岡
Year and Date
2012-12-14
Related Report
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[Presentation] Role of the mTORC1 signaling pathway in acquired immunity.2012
Author(s)
Matsuda, S., Nagai, S., Hoshii, T., Koyasu, S., Hirao, A., and Ohtani, M.
Organizer
第35回日本分子生物学会年会
Place of Presentation
福岡
Year and Date
2012-12-13
Related Report
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