Analysis on the mechanism of immune regulation by CD200R3+ Naturally occurring regulatory dendritic cells

• Project/Area Number: 22590441
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Immunology
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: SATO Katsuaki 独立行政法人理化学研究所, 樹状細胞機能研究チーム, チームリーダー (40301147)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 樹状細胞 / T細胞 / 免疫寛容 / 免疫応答制御 / 免疫疾患

Research Abstract

Deficiency of CD200R3 suppressed the T-cell regulatory function of naturally occurring regulatory dendritic cells. Furthermore, CD200R3+naturally occurring regulatory dendritic cell-deficient mice showed a more enhanced immune pathogenesis than wild-type mice. Therefore, our findings suggest that CD200R3 plays a crucial role in the T-cell regulatory function of naturally occurring regulatory dendritic cells.

Research Products

• [Journal Article] Conditional ablation of CD205+ conventional dendritic cells impacts the regulation of T cell immunity and homeostasis in vivo (2012)
  • Author(s): Fukaya, T.
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 109巻 Issue: 28 Pages: 11288-11293
  • DOI: 10.1073/pnas.1202208109
  • Peer Reviewed
• [Journal Article] Crucial role of plasmacytoid dendritic cells in the initiation of inflammation and T cell immunity in vivo (2011)
  • Author(s): Takagi, H.
  • Journal Title: Immunity Volume: 35 Pages: 958-971
  • Peer Reviewed
• [Journal Article] DCs in immune tolerance in steady-state conditions. (2011)
  • Author(s): Fukaya, T., Takagi, H., Taya H., Sato, K.
  • Journal Title: Methods Mol.Biol. Volume: 677 Pages: 113-126
  • Peer Reviewed
• [Journal Article] Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph nodedendritic cells in the generation of antigen-specific CD4^+Foxp3^+regulatory T cells in the establishment of oral tolerance. (2010)
  • Author(s): FukaYa, T., Takagi, H., Sato, Y., Sato, K., Eizumi, K., Taya, H., Shin, T., Chen, L., Dong, C., Azuma, M., Yagita, H., Malissen, B., Sato, K.
  • Journal Title: Blood Volume: 116 Pages: 2266-2276
  • Peer Reviewed
• [Presentation] 生体内での炎症反応とT細胞免疫応答の制御における形質細胞様樹状細胞の役割 (2012)
  • Author(s): 高木秀明、佐藤克明
  • Organizer: 第21回東京免疫フォーラム
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2012-03-08
• [Presentation] Plasmacytoid Dendritic Cells in Innate and Adaptive Immunity (2012)
  • Author(s): 佐藤克明
  • Organizer: 大阪大学免疫学フロンティア研究センターセミナー
  • Place of Presentation: 大阪(招待講演)
  • Year and Date: 2012-02-23
• [Presentation] 樹状細胞による免疫応答制御～経口免疫寛容の成立における腸間膜リンパ節樹状細胞の役割 (2012)
  • Author(s): 佐藤克明
  • Organizer: (財)日本生物科学研究所第二研究会セミナー
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2012-02-15
• [Presentation] Plasmacytoid dendritic cells are crucial for the initiation of inflammation and T cell immunity in vivo (2012)
  • Author(s): 佐藤克明
  • Organizer: The 12th International Symposium on Dendritic Cells
  • Place of Presentation: Daegu, Korea
• [Presentation] Critical role of Siglec-H in the function of plasmacytoid dendritic cells for the regulation of inflammation and T cell immunity in vivo (2012)
  • Author(s): 佐藤克明
  • Organizer: The 12th International Symposium on Dendritic Cells
  • Place of Presentation: Daegu, Korea
• [Presentation] Conditional ablation of CD205+ conventional dendritic cells impacts the regulation of T cell immunity and homeostasis in vivo (2012)
  • Author(s): 佐藤克明
  • Organizer: 第41回日本免疫学会総会
  • Place of Presentation: 大阪
• [Presentation] 経口免疫寛容の成立における腸間膜リンパ節樹状細胞の役割 (2011)
  • Author(s): 佐藤克明
  • Organizer: 第32回和漢医薬学総合研究所特別セミナー
  • Place of Presentation: 富山(招待講演)
  • Year and Date: 2011-12-09
• [Presentation] Crucial role of plasmacytoid dendritic cells in the regulation of inflammation and T cell immunity in vivo (2011)
  • Author(s): 高木秀明
  • Organizer: 第40回日本免疫学会総会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-28
• [Presentation] Critical role of Siglec-H in the function of plasmacytoid dendritic cells for the regulation of inflammation and T cell immunity in vivo (2011)
  • Author(s): 佐藤克明
  • Organizer: 第40回日本免疫学会総会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-28
• [Presentation] マウスの経口免疫寛容の分子作用機構～画期的な食物アレルギー治療の可能性へ (2011)
  • Author(s): 佐藤克明
  • Organizer: 未来へのバイオ技術"勉強会月例会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-11-08
• [Presentation] Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4^+Foxp3^+ regulatory T cells in the establishment of oral tolerance (2010)
  • Author(s): 佐藤克明
  • Organizer: 第60回日本アレルギー学会秋季学術大会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2010-11-25
• [Presentation] Control of Immune Response by Regulatory Dendritic Cells (2010)
  • Author(s): 佐藤克明
  • Organizer: 第72回日本血液学会学術集会シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-24
• [Presentation] Essential roles of B7-H1 and B7-DC in the establishment of oral tolerance mediated through the de novo generation of antigen-specific CD4^+Foxp3^+ inducible regulatory T cells (2010)
  • Author(s): Fukaya, T., Takagi, H., Sato, K.
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: Kobe
  • Year and Date: 2010-08-24
• [Presentation] Role of the B7 family of costimulatory molecules expressed on systemic and mesenteric lymph node dendritic cells in the differentiation of CD4^+Foxp3^+ regulatory T cells and T_H17 cells. (2010)
  • Author(s): Takagi, H., Fukaya, T., Sato, K.
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: Kobe
  • Year and Date: 2010-08-24
• [Presentation] Regulatory dendritic cells protect against allergic airway inflammation in a murine asthmatic model. (2010)
  • Author(s): Sato, K., Fukaya, T., Takagi, H.
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: Kobe
  • Year and Date: 2010-08-24
• [Presentation] 樹状細胞による免疫応答制御 (2010)
  • Author(s): 佐藤克明
  • Organizer: 第20回日本樹状細胞研究会
  • Place of Presentation: 新潟
  • Year and Date: 2010-06-18
• [Presentation] Crucial role of plasmacytoid dendritic cells for the regulation of inflammation and T cell immunity in vivo (2010)
  • Author(s): 佐藤克明
  • Organizer: 1^<st> NZ-RIKEN-CHIBA Workshop
  • Place of Presentation: 横浜
  • Year and Date: 2010-06-14
• [Book] 免疫の事典 (2011)
  • Author(s): 佐藤克明
  • Total Pages: 473
  • Publisher: 朝倉書店
• [Remarks]
  • URL: http://www.riken.jp/r-world/research/lab/rcai/cell/index.html