Analysis on the mechanism of immune regulation by CD200R3+ Naturally occurring regulatory dendritic cells
Project/Area Number |
22590441
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Immunology
|
Research Institution | The Institute of Physical and Chemical Research |
Principal Investigator |
SATO Katsuaki 独立行政法人理化学研究所, 樹状細胞機能研究チーム, チームリーダー (40301147)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 樹状細胞 / T細胞 / 免疫寛容 / 免疫応答制御 / 免疫疾患 |
Research Abstract |
Deficiency of CD200R3 suppressed the T-cell regulatory function of naturally occurring regulatory dendritic cells. Furthermore, CD200R3+naturally occurring regulatory dendritic cell-deficient mice showed a more enhanced immune pathogenesis than wild-type mice. Therefore, our findings suggest that CD200R3 plays a crucial role in the T-cell regulatory function of naturally occurring regulatory dendritic cells.
|
Report
(4 results)
Research Products
(23 results)
-
-
-
-
[Journal Article] Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph nodedendritic cells in the generation of antigen-specific CD4^+Foxp3^+regulatory T cells in the establishment of oral tolerance.2010
Author(s)
FukaYa, T., Takagi, H., Sato, Y., Sato, K., Eizumi, K., Taya, H., Shin, T., Chen, L., Dong, C., Azuma, M., Yagita, H., Malissen, B., Sato, K.
-
Journal Title
Blood
Volume: 116
Pages: 2266-2276
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-