Clarification of mechanism underlying Th2-dominat immune response based on cells migrated from sensitized skin
| Project/Area Number |
22590442
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Kyoto University (2011-2012)
The University of Tokyo (2010) |
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Principal Investigator |
TOMURA Michio 京都大学, 医学研究科, 准教授 (30314321)
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| Co-Investigator(Renkei-kenkyūsha) |
KABASHIMA Kenji 京都大学, 医学部, 准教授 (00362484)
KANAGAWA Osam 明石市民病院 (70391919)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | アレルギー / 免疫関連疾患 / 免疫学 / 皮膚炎 / カエデマウス |
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| Research Abstract |
In order to understand the mechanism underlying establishment of Th2-dominat immune response in allergic skin dermatitis, we attempted to determine spatiotemporal regulation of movement and antigen-carry of dendritic cell subsets migrated from skin to the draining lymph node. We found that particularly CD103-dermal dendritic cells replaced rapidly in skin and lymph node, and were responsible for enhanced continuous migration for more than 3 days and exogenous protein antigen carry after mechanical stress of skin.
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Report
(4 results)
Research Products
(21 results)
