Analysis of positive selection process during T eell development via large transcription factor

• Project/Area Number: 22590443
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Immunology
• Research Institution: Institute for Developmental Research, Aichi Human Service Center (2011-2012); The Institute of Physical and Chemical Research (2010)
• Principal Investigator: TAKAGI Tsuyoshi 愛知県心身障害者コロニー発達障害研究所, 周生期学部, 主任研究員 (70300879)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 転写因子 / positive selection / T細胞 / Zn-フィンガー / 転写制御因子 / Zn-finger / 免疫 / ositive selection / リンパ球 / 細胞分化 / クロマチン

Research Abstract

Our bodies are protected from foreign bodies with sophisticated immune system. Establishment of acquired immune system should be highly regulated. Because destruction of this process means that ourselves might be exposed to attack from our immune cells. It is very important to understand how suitable T cells are selected to develop. In this study, I revealed how the transcription factor, that is essential for this process, regulates downstream genes to achieve it.

Research Products

• [Journal Article] Deficiency of Schnurri-2, a MHC enhancer binding protein, induce mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizopherenia (2013)
  • Author(s): Keizo Takao, Katsunori Kobayashi, Hideo Hagihara, Koji Ohira, Hirotaka Shoji, Satoko Hattori, Hisatsugu Koshimizu, Juzoh Umemori, Keiko Toyama, Hironori K Nakamura, Mahomi Kuroiwa, Jun Maeda, Kimie Atsuzawa, Kayoko Esaki, Shun Yamaguchi, Shigeki Furuya, Tsuyoshi Takagi, Noah M Walton, Nobuhiro Hayashi, Hidenori Suzuki, Makoto Higuchi, Nobuteru Usuda, Tetsuya, Suhara, Akinori Nishi, Mitsuyuki Matsumoto, Shunsuke Ishii & Tsuyoshi Miyakawa
  • Journal Title: Neuropsychopharmacology Volume: (in press)
  • Peer Reviewed
• [Journal Article] Deficiency of Schnurri-2, a MHC enhancer binding protein, induce mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizopherenia (2013)
  • Author(s): Keizo Takao
  • Journal Title: Neuropsychopharmacology Volume: in press
  • Peer Reviewed
• [Journal Article] Dampening of death pathways by schnurri-2 is essential for T-cell development (2011)
  • Author(s): Staton TL, Lazarevic V, Jones DC, Lanser AJ, Takagi T, Ishii S, Glimcher LH
  • Journal Title: Nature Volume: 472 Issue: 7341 Pages: 105-109
  • DOI: 10.1038/nature09848
  • Peer Reviewed
• [Journal Article] Uncoupling of growth plate maturation and bone formation in mice lacking both Schnurri-2 and Schnurri-3. (2010)
  • Author(s): Jones DC
  • Journal Title: Proc.Natl Acad.Sci.USA Volume: 107 Pages: 8254-8258
  • Peer Reviewed
• [Journal Article] Dampening of death pathways by Schnurri-2 is essential for T cell development.
  • Author(s): Staton TL
  • Journal Title: Nature Volume: (In press)
  • Peer Reviewed
• [Presentation] de novo型Sip1ヘテロ変異マウスを用いたMowat-Wilson syndromeのモデル動物としての有用性の検討 (2013)
  • Author(s): 高木豪, 東雄二郎
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2013-12-11
• [Presentation] Positive selectionに必要なSchnurr-2のchip on chip法を用いた解析 (2010)
  • Author(s): 高木豪, 石井俊輔
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-14
• [Presentation] Chip on chip analysis of transcription factor, Schnurri-2 using DP cells. (2010)
  • Author(s): 高木豪、石井俊輔
  • Organizer: 日本分子生物学会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2010-12-09
• [Presentation] de novo型Sip1ヘテロ変異マウスを用いたMowat-Wilson syndromeのモデル動物としての有用性の検討
  • Author(s): 高木豪
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: マリンメッセ福岡（福岡）
• [Remarks]
  • URL: http://www.inst-hsc.jp/
• [Remarks]
  • URL: http://rtcweb.rtc.riken.jp/lab/mg/mg.html