Analysis of positive selection process during T eell development via large transcription factor
| Project/Area Number |
22590443
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Institute for Developmental Research, Aichi Human Service Center (2011-2012)
The Institute of Physical and Chemical Research (2010) |
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Principal Investigator |
TAKAGI Tsuyoshi 愛知県心身障害者コロニー発達障害研究所, 周生期学部, 主任研究員 (70300879)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 転写因子 / positive selection / T細胞 / Zn-フィンガー / 転写制御因子 / Zn-finger / 免疫 / ositive selection / リンパ球 / 細胞分化 / クロマチン |
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| Research Abstract |
Our bodies are protected from foreign bodies with sophisticated immune system. Establishment of acquired immune system should be highly regulated. Because destruction of this process means that ourselves might be exposed to attack from our immune cells. It is very important to understand how suitable T cells are selected to develop. In this study, I revealed how the transcription factor, that is essential for this process, regulates downstream genes to achieve it.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Deficiency of Schnurri-2, a MHC enhancer binding protein, induce mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizopherenia2013
Author(s)
Keizo Takao, Katsunori Kobayashi, Hideo Hagihara, Koji Ohira, Hirotaka Shoji, Satoko Hattori, Hisatsugu Koshimizu, Juzoh Umemori, Keiko Toyama, Hironori K Nakamura, Mahomi Kuroiwa, Jun Maeda, Kimie Atsuzawa, Kayoko Esaki, Shun Yamaguchi, Shigeki Furuya, Tsuyoshi Takagi, Noah M Walton, Nobuhiro Hayashi, Hidenori Suzuki, Makoto Higuchi, Nobuteru Usuda, Tetsuya, Suhara, Akinori Nishi, Mitsuyuki Matsumoto, Shunsuke Ishii & Tsuyoshi Miyakawa
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Journal Title
Neuropsychopharmacology
Volume: (in press)
Related Report
Peer Reviewed
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