Medical Economic Evaluation of Noninvasive Blood Glucose Measurement with Respect to Sensitivity and Specificity.

• Project/Area Number: 22590492
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical sociology
• Research Institution: Meijo University
• Principal Investigator: SAKAMAKI Hiroyuki 名城大学, 薬学部, 教授 (40317334)
• Co-Investigator(Renkei-kenkyūsha): OKAMORO Mitsuyoshi 名城大学, 薬学部, 教授 (60434619) ; SAITO Yoshihiro 豊橋技術科学大学, 工学部, 准教授 (00303701)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 医療経済学 / 糖尿病 / ガスクロマトグラフ－質量分析計 / 支払意志額 / 診断テスト分析 / GC/MS / 医療経済 / 仮想市場法

Research Abstract

The study evaluated the usefulness of breath analysis as a noninvasive method of blood glucose measurement from both the scientific and economic viewpoint. A needle-type extraction device has been developed for efficient condensation of volatile organic substances contained in breath such as acetone, and the acetone concentration in breath was measured in healthy subjects and diabetic patients to evaluate the correlation with values obtained by blood testing. The economic value of this measurement method was evaluated by questionnaire survey on intention to pay in healthy subjects. Results suggest that it would be feasible to use this breath analysis for detection of diabetes.

Research Products

• [Journal Article] Column Switching Analysis with Packed-Capillary Columns in Gas Chromatography (2012)
  • Author(s): I. Ueta, K. Takahashi, Y. Saito;
  • Journal Title: Analytical Sciences Volume: 28 Pages: 953-957
  • NAID: 10031123427
  • Peer Reviewed
• [Journal Article] Novel Sample Preparation Technique with Needle-Type Micro-Extraction Device for Volatile Organic Compounds in Indoor Air Samples (2012)
  • Author(s): I. Ueta, A. Mizuguchi, K. Fujimura, S.Kawakubo, Y. Saito;
  • Journal Title: Analytica Chimica Acta Volume: 746 Pages: 77-83
  • Peer Reviewed
• [Journal Article] Column Switching Analysis with Packed-Capillary Columns in Gas Chromatography. (2012)
  • Author(s): I. Ueta
  • Journal Title: Analytical Sciences Volume: 28 Pages: 953-957
  • Peer Reviewed
• [Journal Article] ガスクロマトグラ フィーのための針型試料前処理デバイス (2011)
  • Author(s): 植田郁生, 齊戸美弘;
  • Journal Title: 分析化学 Volume: 60 Pages: 833-844
  • NAID: 10030038180
  • Peer Reviewed
• [Journal Article] Retention Behavior of Fluorobenzenes on Fluoro-Derivatized Poly(p-phenylene terephthalamide) Fibrous Stationary Phases in Microcolumn Liquid Chromatography (2011)
  • Author(s): S. Shirai, K. Nakane, I. Ueta, Y. Saito;
  • Journal Title: Chromatography Volume: 32 Pages: 127-133
  • NAID: 10030146100
  • Peer Reviewed
• [Journal Article] High Temperature Separations on a Polymer-Coated Fibrous Stationary Phase in Microcolumn Liquid Chromatography (2011)
  • Author(s): K. Nakane, S. Shirai, Y. Saito, Y. Moriwake, I.Ueta, M. Inoue, K. Jinno;
  • Journal Title: Analytical Sciences Volume: 27 Pages: 811-816
  • NAID: 10029600211
  • Peer Reviewed
• [Journal Article] Needle-Type Sample Preparation Devices for Gas Chromatographic Analysis (2011)
  • Author(s): 植田郁生
  • Journal Title: BUNSEKI KAGAKU Volume: 60 Issue: 11 Pages: 833-844
  • DOI: 10.2116/bunsekikagaku.60.833
  • NAID: 10030038180
  • ISSN: 0525-1931
  • Peer Reviewed
• [Journal Article] Novel Fire Investigation Technique Using Needle Extraction in Gas Chromatography (2010)
  • Author(s): I. Ueta, Y. Saito, K. Teraoka, H. Matsuura, K.Fujimura, K. Jinno;
  • Journal Title: Analytical Sciences Volume: 26 Pages: 1127-1132
  • NAID: 10027315935
  • Peer Reviewed
• [Journal Article] Retention Behavior on Aminoethyl-Modified Poly(p-phenylene terephthalamide) Fiber Stationary Phases in Gas Chromatography (2010)
  • Author(s): S. Shirai, Y. Saito, Y. Sakurai, I. Ueta, K.Jinno;
  • Journal Title: Analytical Sciences Volume: 26 Pages: 1011-1014
  • NAID: 10026785477
  • Peer Reviewed
• [Journal Article] Rapid Temperature-Programmed Separation and Retention Prediction on Novel Packed-Capillary Column in Gas Chromatography (2010)
  • Author(s): M. Inoue, Y. Saito, I. Ueta, T. Miura, H.Ohkita, K. Fujimura, K. Jinno;
  • Journal Title: Analytical Sciences Volume: 26 Pages: 687-691
  • NAID: 10026784116
  • Peer Reviewed
• [Journal Article] Determination of Volatile OrganicCompounds for a Systematic Evaluation ofThird-Hand Smoking (2010)
  • Author(s): I. Ueta, Y. Saito, K. Teraoka, T. Miura, K.Jinno;
  • Journal Title: Analytical Sciences Volume: 26 Pages: 569-574
  • Peer Reviewed
• [Journal Article] Rapid Temperature-Programmed Separation and Retention Prediction on Novel Packed-Capillary Column in Gas Chromatography (2010)
  • Author(s): M.Inoue
  • Journal Title: Analytical Sciences Volume: 26巻 Pages: 687-691
  • Peer Reviewed
• [Journal Article] Retention Behavior on Aminoethyl-Modified Poly(p-phenyleneterephthalamide) Fiber Stationary Phases in Gas Chromatography (2010)
  • Author(s): S.Shirai
  • Journal Title: Analytical Sciences Volume: 26巻 Pages: 1011-1014
  • Peer Reviewed
• [Presentation] Miniaturized Sample Preparation Needle for Human Breath Analysis in Capillary Gas Chromatography (2012)
  • Author(s): Y. Saito, I. Ueta, K. Fujimura, S. Ellwood, H.Wada, M. Hosoe, M. Ishiguro, H. Sakamaki, M. Okamoto;
  • Organizer: 2012 International Breath Analysis Meeting (Breath 2012)
  • Place of Presentation: Fairmont Sonoma Mission Inn and Spa, Sonoma, CA, USA.
  • Year and Date: 2012-10-29
• [Presentation] Miniaturized Sample PreparationDevices for Various Analytical Situations (2011)
  • Author(s): Y. Saito;
  • Organizer: 11th Asia Pacific International Symposium onMicroscale Separations and Analysis (APCE2011)
  • Place of Presentation: University ofTasmania, Hobart, Tasmania, Australia.
  • Year and Date: 2011-11-26
• [Presentation] Miniaturized Sample Preparation Devices for Various Analytical Situations (2011)
  • Author(s): Y.Saito
  • Organizer: 11th Asia Pacific International Symposium on Microscale Separations and Analysis (APCE 2011)
  • Place of Presentation: タスマニア大学(オーストラリア,タスマニア州,ホバート市)(招待講演)
  • Year and Date: 2011-11-26
• [Presentation] 室内環境測定用新規針型試料前処理デバイスの開発 (2011)
  • Author(s): 植田郁生
  • Organizer: 第22回クロマトグラフィー科学会議
  • Place of Presentation: 東北大学(宮城県仙台市)(口頭発表)
  • Year and Date: 2011-10-22
• [Presentation] 針型試料前処理デバイスの開発と応用 (2011)
  • Author(s): 齊戸美弘
  • Organizer: 日本分析化学会第60年会ガスクロマトグラフィー研究懇談会特別講演会
  • Place of Presentation: 愛知県名古屋市・名古屋大学
  • Year and Date: 2011-09-14
• [Presentation] 針型試料前処理デバイスの開発と応用 (2011)
  • Author(s): 齊戸美弘
  • Organizer: 日本分析化学会第60年会
  • Place of Presentation: 名古屋大学(愛知県名古屋市)(招待講演)
  • Year and Date: 2011-09-14
• [Presentation] Miniaturized Sample Preparation Device Designed for Gas Chromatographic Analysis of Various Volatile Organic Compounds (2011)
  • Author(s): Y. Saito
  • Organizer: Separation Science Asia 2011--New Horizons in Separation and Detection Techniques--
  • Place of Presentation: The Biopolis Science Park, Singapore, Singapore.
  • Year and Date: 2011-07-28
• [Presentation] Miniaturized Sample Preparation Device Designed for Gas Chromatographic Analysis of Various Volatile Organic Compounds (2011)
  • Author(s): Y.Saito
  • Organizer: Separation Science Asia 2011--New Horizons in Separation and Detection Techniques--
  • Place of Presentation: バイオポリスサイエンスパーク(シンガポール)(招待講演)
  • Year and Date: 2011-07-28
• [Presentation] Rapid Temperature Programming and Retention Prediction on Novel Packed-Capillary Columns in Gas Chromatography (2011)
  • Author(s): Y.Saito
  • Organizer: 62nd Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy(PITTCON2011)
  • Place of Presentation: Georgia World Congress Center(米国,アトランタ)
  • Year and Date: 2011-03-17
• [Presentation] Miniaturized Sample PreparationDevice for Gas Chromatographic Analysis of Volatile Organic Compounds (2010)
  • Author(s): Y. Saito;
  • Organizer: The International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
  • Place of Presentation: Hawaii Convention Center, Honolulu, Hawaii, HI, USA.
  • Year and Date: 2010-12-19
• [Presentation] Miniaturized Sample Preparation Device for Gas Chromatographic Analysis of Volatile Organic Compounds (2010)
  • Author(s): Y.Saito
  • Organizer: The International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
  • Place of Presentation: Hawaii Convention Center(米国,ホノルル)
  • Year and Date: 2010-12-19
• [Presentation] マイクロ試料前処理技術の新展開 (2010)
  • Author(s): 齊戸美弘
  • Organizer: 第41回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 愛知県豊橋市・豊橋技術科学大学
  • Year and Date: 2010-11-06
• [Presentation] マイクロ試料前処理技術の新展開 (2010)
  • Author(s): Y.Saito
  • Organizer: 第41回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 豊橋技術科学大学(愛知県豊橋市)
  • Year and Date: 2010-11-06
• [Presentation] Miniaturized Sample Preparation Needle in GC for the Clinical Field. (2010)
  • Author(s): M.Okamoto, H.Sakamakil, I.Ueda, M.Hosoe, Y.Saito
  • Organizer: 70th FIP World Congress of Pharmacy/Pharmaceutical Sciences
  • Place of Presentation: Lisbon Congress Centre(ポルトガル,リスボン)
  • Year and Date: 2010-08-31
• [Presentation] Sample Preparation Device for Human Breath Analysis in Capillary Gas Chromatography (2010)
  • Author(s): Y. Saito
  • Organizer: 34th International Symposium on Capillary Chromatography (ISCC 2010)
  • Place of Presentation: Palazzo dei Congressi, Riva del Garda, Italy.
  • Year and Date: 2010-06-04
• [Presentation] Sample Preparation Device for Human Breath Analysis in Capillary Gas Chromatography (2010)
  • Author(s): Y.Saito
  • Organizer: 34th International Symposium on Capillary Chromatography (ISCC 2010)
  • Place of Presentation: Palazzo dei Congressi(イタリア,リバデルガルダ)
  • Year and Date: 2010-06-04
• [Presentation] Novel Packed Capillary Columns in Gas Chromatography (2010)
  • Author(s): I.Ueta
  • Organizer: 34th International Symposium on Capillary Chromatography (ISCC 2010)
  • Place of Presentation: Palazzo dei Congressi(イタリア,リバデルガルダ)
  • Year and Date: 2010-06-04
• [Presentation] Miniaturized Sample Preparation Needle for Human Breath Analysis in Capillary Gas Chromatography
  • Author(s): Y. Saito
  • Organizer: 2012 International Breath Analysis Meeting
  • Place of Presentation: Sonoma, CA, USA.
• [Book] Needle Trap Devices for Environmental Sample Preparation" in "Comprehensive Sampling and Sample Preparation (2012)
  • Author(s): Y. Saito, I. Ueta, M. Ogawa, K. Jinno;
  • Total Pages: 23
  • Publisher: J. Pawliszyn (ed.), Elsevier Science B.V., Amsterdam
• [Book] Comprehensive Sampling and Sample Preparation (2012)
  • Author(s): Y. Saito
  • Total Pages: 3200
  • Publisher: Elsevier Science