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Establishment of novel evaluation methods to measure endothelial functions as a clinical pharmacological tool

Research Project

Project/Area Number 22590499
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied pharmacology
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

TAKEUCHI Kazuhiko  浜松医科大学, 医学部, 准教授 (00419425)

Co-Investigator(Kenkyū-buntansha) WATANABE Hiroshi  浜松医科大学, 医学部, 教授 (50262803)
INUI Naoki  浜松医科大学, 医学部, 助教 (80402254)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2010: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords血管内皮機能 / 反応性充血 / 近赤外線時間分解分光法
Research Abstract

The evaluation method using reactive hyperemia (RHE) to measure endothelial function is useful for detecting the early phase of atherosclerotic changes. Atherosclerotic changes like peripheral arterial disease are found much more in legs than in arms, however, the current methods for evaluating endothelial function with ultrasound graph (FMD) or peripheral tonometry (EndoPAT) are limited to ‘arm’ RHE due to technical difficulties in measuring ‘leg’ RHE. The present study established a novel method to measure ‘leg’ RHE by using a near-infrared time-resolved spectroscopy (NIRTRS). In arm RHE measured by NIRTRS, there was no difference of RHE patterns among 20s, 50s and 70s men groups, however the leg RHE patterns of 50s and 70s men groups were lower than that of 20s men group. Thus, the leg RHE measured by NIRTRS could be a biomarker for detecting the early phase of aging changes in vascular function and evaluating drug effectson the vascular functional changes.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (9 results)

All 2012 2011 2010 Other

All Presentation (8 results) Remarks (1 results)

  • [Presentation] Biomarkers for Endothelial Function.2012

    • Author(s)
      Takeuchi K, Watanabe H
    • Organizer
      第33回日本臨床薬理学会学術総会 BPS/JSCPT Joint Symposium
    • Place of Presentation
      那覇
    • Year and Date
      2012-11-29
    • Related Report
      2012 Final Research Report
  • [Presentation] Biomarkers for Endothelial Function2012

    • Author(s)
      竹内和彦
    • Organizer
      第33 回日本臨床薬理学会学術総会 BPS/JSCPT Joint Symposium
    • Place of Presentation
      沖縄県那覇市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Inhibitory effects of Omega-6 polyunsaturated fatty acids on endothelial function2011

    • Author(s)
      Wei J, Takeuchi K, Inui N, Watanabe H
    • Organizer
      The 5th China-Japan Joint Meeting of Basic and Clinical Pharmacology
    • Place of Presentation
      Urumqi, China
    • Year and Date
      2011-08-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Omega-6 PUFA- induced endothelial dysfunction2011

    • Author(s)
      Wei J, Takeuchi K Watanabe H
    • Organizer
      第75 日本循環器学会学術年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Omega-6 PUFA-induced endothelial dysfunction2011

    • Author(s)
      Wei Jiazhag, Kazuhiko Takeuchi
    • Organizer
      第75日本循環器学会学術年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] 血管皮細胞機能に対する遊離脂肪酸の影響2011

    • Author(s)
      竹内和彦, Wei Jiazhang, 渡邉裕司
    • Organizer
      第4回静岡県血栓と血管フォーラム
    • Place of Presentation
      静岡
    • Year and Date
      2011-01-02
    • Related Report
      2012 Final Research Report
  • [Presentation] ω6-polyunsatulated fatty acids, but not other free fatty acids, evoke endothelial dysfunction by inhibiting store-operated Caentries.2010

    • Author(s)
      竹内和彦、Wei Jiazhang、乾直輝、渡邉裕司
    • Organizer
      16th World congress on Basic and Clinical Pharmacology
    • Place of Presentation
      デンマーク
    • Year and Date
      2010-07-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] The functional changes in regenerated endothelial cells.2010

    • Author(s)
      竹内和彦、渡邉裕司
    • Organizer
      XXth World Congress of the ISHR
    • Place of Presentation
      京都
    • Year and Date
      2010-05-13
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www2.hama-med.ac.jp/w1b/cpharm/clinpharm.html

    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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