| Project/Area Number |
22590510
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
TERAWAKI Kiyoshi 独立行政法人国立がん研究センター, 研究所, ユニット長 (20572465)
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| Co-Investigator(Kenkyū-buntansha) |
UEZONO Yasuhito 独立行政法人国立がん研究センター, 研究所, 分野長 (20213340)
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| Co-Investigator(Renkei-kenkyūsha) |
MATOBA Motohiro 独立行政法人国立がん研究センター, 中央病院, 医長 (20199904)
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| Research Collaborator |
YANAGIHARA Kazuyoshi 独立行政法人国立がん研究センター, 早期・探索臨床研究センター, 特任研究員 (20158025)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | がん悪液質 / 六君子湯 / グレリン / サイトカイン / 食欲不振 |
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| Research Abstract |
Cancer cachexia, a multi-factorial syndrome characterized by anorexia and the loss of body weight, causes poor quality of life (QOL). We developed a novel cancer cachexia animal model using a novel cell line derived from human gastric cancer cell line. In this model, the reduced susceptibility to the appetite promoting peptide ghrelin was observed. Rikkunshito, a traditional Japanese medicine, ameliorated cachexia status in the model and the ameliorative effects of cachexia by rikkunshito were suggested to be due to the enhancement of ghrelin-induced intracellular signaling. Our findings demonstrate that rikkunshito may contribute to the improvement of QOL in patients with cancer cachexia.
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