| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
We examined the effects of a variety of drugs on classical inwardly rectifying K^+ (Kir2) channels and G-protein-activated inwardly rectifying K^+ (GIRK；Kir3) channels using the Xenopus oocyte expression system. We found that the selective norepinephrine reuptake inhibitors: atomoxetine and reboxetine, and phencyclidine inhibited GIRK channels. Furthermore, several classes of antidepressants inhibited GIRK channels with various degrees of potency and effectiveness. These findings may help advance our understanding of their clinical effects and side effects and suggest molecular basis of drug discovery and new indications of known drugs.
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