Discovery of drugs active at inwardly rectifying K^+ channels
| Project/Area Number |
22590512
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | 公益財団法人東京都医学総合研究所 (2012)
Tokyo Metropolitan Organization for Medical Research (2010-2011) |
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Principal Investigator |
KOBAYASHI Toru 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 研究員 (70450583)
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Kazutaka 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 参事研究員 (60281656)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 薬理学 / 創薬 / カリウムチャネル |
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| Research Abstract |
We examined the effects of a variety of drugs on classical inwardly rectifying K^+ (Kir2) channels and G-protein-activated inwardly rectifying K^+ (GIRK；Kir3) channels using the Xenopus oocyte expression system. We found that the selective norepinephrine reuptake inhibitors: atomoxetine and reboxetine, and phencyclidine inhibited GIRK channels. Furthermore, several classes of antidepressants inhibited GIRK channels with various degrees of potency and effectiveness. These findings may help advance our understanding of their clinical effects and side effects and suggest molecular basis of drug discovery and new indications of known drugs.
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Report
(4 results)
Research Products
(11 results)
