The expression of Toll-like receptor in myelodysplastic syndrome

• Project/Area Number: 22590515
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Gunma University
• Principal Investigator: MURAKAMI Hirokazu 群馬大学, 大学院・保健学研究科, 教授 (40166260)
• Co-Investigator(Kenkyū-buntansha): SAITO Takayuki 群馬大学, 大学院・保健学研究科, 准教授 (80375542) ; HANDA Hiroshi 群馬大学, 医学部, 講師 (90282409) ; 小河原 はつ江 群馬大学, 大学院・保健学研究科, 教授 (60134293)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 骨髄異形成症候群 / Toll-like receptor / apoptosis / 白血病 / myelodysplastic syndrome / RCMD / RAEB

Research Abstract

Myelodysplastic syndrome (MDS) is a clonal disease, characterized by ineffective hematopoiesis due to apoptosis of blood cells, progression to acute leukemia, and high frequency of autoimmune disease complications. Toll-like receptors (TLR) is reported to be involved in apoptosis, tumor immunity, and autoimmune disease. According to these, it is suspected that TLRs are associated with the pathogenesis of MDS. Twenty-one patients with MDS are included in this study. TLRs may be associated with the apoptosis of blood cells in high-risk MDS patients; however not be involved in the progression of MDS to leukemia.

Research Products

• [Journal Article] TCL1A gene involvement in T-cel l prolymphocytic leukemia in Japanese patients (2012)
  • Author(s): Yokohama A, Saitoh A, Nakahashi H, Mitsui T, Koiso H, Kim Y, Uchiumi H, Saitoh T, Handa H, Jimbo T, Murayama K, Sakura T, Murakami H, Karasawa M, Nojima Y, Tsukamoto N
  • Journal Title: Int J Hematol Volume: 95 Pages: 77-85
  • NAID: 10030266898
  • Peer Reviewed
• [Journal Article] Long-term follow-up of EBV-positive lymphoproliferative disorders in a patient with systemic lupus erythematosus (2011)
  • Author(s): Tsukamoto N, Handa H, Yokohama A, Mitsui T, Saitoh T, Koiso H, Uchiumi H, Hoshino T, Karasawa M, Murakami H, Kojima M, Nojima Y
  • Journal Title: Med Mol Morphol Volume: 44 Issue: 4 Pages: 237-241
  • DOI: 10.1007/s00795-011-0551-6
  • NAID: 10030464181
  • Peer Reviewed
• [Journal Article] Interleukin-17F gene polymorphism in patients with chronic immune thrombocytopenia (2011)
  • Author(s): Saitoh T, Tsukamoto N, Koiso H, Mitsui T, Yokohama A, Handa H, Karasawa M, Ogawara H, Nojima Y, Murakami H
  • Journal Title: Eur J Haematol Volume: 87 Issue: 3 Pages: 253-258
  • DOI: 10.1111/j.1600-0609.2011.01651.x
  • Peer Reviewed
• [Journal Article] Sunitinib induced immune thrombocytopenia (2011)
  • Author(s): Matsumoto K, Yokohama A, Yuzuriha A, Toyama K, Mitsuin T, Hashimoto Y, Koiso H, Saitoh T, Uchiumi H, Handa H, Karasawa M, Murakami H, Matshui H, Suzuki K, Tsukamoto N, Nojima Y
  • Journal Title: Kitakanto Medical Journal Volume: 61 Pages: 175-177
  • NAID: 130000872629
  • Peer Reviewed
• [Journal Article] Successful treatment of autoimmune hemolytic anemia associated with multicentric castleman disease by anti-interleukin-6 receptor antibody (tocilizumab) therapy. 2011 : 126(3) (2011)
  • Author(s): Yuzuriha A, Saitoh T, Koiso H, Mitsui T, Uchiumi H, Yokohama A, Handa H. Kojima M. Tsukamoto N, Karaswa M, Murakami H, Nojima Y
  • Journal Title: Acta Haematol Volume: 126 Issue: 3 Pages: 147-50
  • DOI: 10.1159/000328426
  • Peer Reviewed
• [Journal Article] Differences in the JAK2 and MPL Mutation status in the cell lineages of the bcr/abl-negative chronic myeloproliferative neoplasm subtypes (2011)
  • Author(s): Toyama K, Karasawa M, Yokohama A, Mitsui T, Uchiumi H, Saitoh T, Handa H, Murakami H, Nojima Y, Tsukamoto N
  • Journal Title: Intern Med Volume: 50 Pages: 2557-2561
  • NAID: 130001288611
  • Peer Reviewed
• [Journal Article] Efficacy of long-term treatment with low-dose thalidomide for patients with relapsed/refractory multiple myeloma (2011)
  • Author(s): Shimizu K, Murakami H, Sawamura M, Hattori Y, Okamoto S, Miwa A, Sugiura I, Shimazaki C, Taniwaki M, Ishida T, Hayashi T, Kosugi H, Yuge M, Iida S, Sunami K, Asaoku A, Sakai A, Abe M, Takagi T
  • Journal Title: Int J Clin Med Volume: 2 Pages: 570-575
  • Peer Reviewed
• [Journal Article] 巨赤芽球性貧血を合併したため定型的病像を欠いた慢性骨髄性白血病 (2011)
  • Author(s): 小磯博美、塚本憲史、島野俊一、唐沢正光、村上博和、野島美久
  • Journal Title: 臨床血液 Volume: 52 Pages: 1772-1776
  • NAID: 10030462518
  • Peer Reviewed
• [Journal Article] 唾液分泌物によるストレス評価の検証-国家試験直前の学生を対象として- (2011)
  • Author(s): 牛木和美、佐藤友香、新井勝哉、井出規文、松井直紀、半田寛、村上博和、小河原はつ江
  • Journal Title: 臨床病理 Volume: 59 Pages: 138-143
  • NAID: 10029426953
  • Peer Reviewed
• [Journal Article] Glossitis by mixed infection of cytomegalovirus and herpes simplex virus during therapy for pure red cell aplasia complicated with Good syndrome (2011)
  • Author(s): Koya H, Yokohama A, Miura A, Hoshino T, Mitsui T, Koiso H, Saitoh T, Uchiumi H, Handa H, Hirato J, Hiromura K, Karasawa M, Murakami H, Tsukamoto N, Nojima Y
  • Journal Title: 臨床血液 Volume: 52 Pages: 708-712
  • NAID: 10029615245
  • Peer Reviewed
• [Journal Article] 特集 多発性骨髄腫update-診療の進歩と新規治療の展望 (2011)
  • Author(s): 斉藤貴之、塚本憲史、村上博和
  • Journal Title: 血液内科 Volume: 62 Pages: 314-323
• [Journal Article] 多発性骨髄腫の分子病態 (2011)
  • Author(s): 横浜章彦、村上博和
  • Journal Title: 内科 Volume: 108 Pages: 192-198
• [Journal Article] 特集 リンパ系腫瘍のresearch questions再発・治療抵抗性骨髄腫治療におけるbortezomib, thalidomide, lenalidomideの合理的な選択法は? (2011)
  • Author(s): 村上博和、斉藤貴之、半田寛
  • Journal Title: 血液内科 Volume: 63 Pages: 66-74
• [Journal Article] 単クローン性γグロブリン血症における血清遊離軽鎖測定の臨床的有用性 (2011)
  • Author(s): 島崎千尋, 村上博和, 澤村守夫, 松田正之, 木下朝博, 畑裕之, 杉浦勇, 津下圭太郎, 名倉英一, 小杉浩史, 伊藤淳治, 清水一之
  • Journal Title: 臨床血液 Volume: 51 Pages: 245-252
  • NAID: 10026332474
  • Peer Reviewed
• [Journal Article] Lenalidomide plus dexamethasone treatment in Japanese patients with relapsed/refractory multiple myeloma. (2010)
  • Author(s): Iida S, Chou T, Okamoto S, Nagai H, Hatake K, Murakami H, Takagi T, Shimizu K, Lau H, Takeshita K, Takatoku M, Hotta T.
  • Journal Title: Int J Hematol Volume: 92 Pages: 118-126
  • NAID: 10026512193
  • Peer Reviewed
• [Presentation] Azacitidine therapy for patients with MDS and AML following MDS in our institute (2012)
  • Author(s): Akio Saitoh, Hiroshi Handa, Hirokazu Murakami, et al
  • Organizer: 74th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Kyoto
• [Presentation] Azacitidine therapy for patients with MDS and AML following MDS i our institute. (2012)
  • Author(s): Akio Saito, Hiroshi Handa, Hirokazu Murakami, et al.
  • Organizer: 74th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Kyoto
• [Presentation] Interleukin-10(IL-10)多型の高産生型は、多発性骨髄腫を進展させる (2011)
  • Author(s): 高荷智紀、斉藤貴之、森山紀彦、牛江千明、星野巧臣、三井健揮、小磯博美、横濱章彦、半田寛、塚本憲史、澤村守夫、小河原はつ江、村上博和
  • Organizer: 第36回日本骨髄腫研究会
  • Place of Presentation: 品川
  • Year and Date: 2011-11-12
• [Presentation] Common fragile site遺伝子FHITとWWOXの骨髄腫における変異 (2011)
  • Author(s): 半田寛、佐々木佳子、高橋範行、服部光、斉藤貴之、小磯博美、横濱章彦、塚本憲史、松本守生、磯田淳、澤村守夫、三井健揮、大崎洋平、村上博和
  • Organizer: 第36回日本骨髄腫研究会
  • Place of Presentation: 品川
  • Year and Date: 2011-11-12
• [Presentation] The IL-18-607A/C and -137G/C polymorphisms are not associated with risk for chronic immune ITP (2011)
  • Author(s): 斉藤貴之、森山紀彦、高荷智紀、牛江千明、星野巧臣、三井健揮、小磯博美、横濱章彦、塚本憲史、野島美久、村上博和
  • Organizer: 第73回日本血液学会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-16
• [Presentation] The cytokine polymorphisms affect the severity of chronic immune thrombocytopenia (ITP) (2011)
  • Author(s): 森山紀彦、高荷智紀、牛江千明、佐々木佳子、高橋範行、服部光、佐藤友香、新井勝哉、井出規文、牛木和美、渡部悟、半田寛、小河原はつ江、斉藤貴之、村上博和
  • Organizer: 第73回日本血液学会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-15
• [Presentation] Study on polymorphism of Interleukin-18 promoter on multiple myeloma (2011)
  • Author(s): 高荷智紀、森山紀彦、牛江千明、佐々木佳子、高橋範行、服部光、佐藤友香、新井勝哉、井出規文、牛木和美、渡部悟、半田寛、小河原はつ江、斉藤貴之、村上博和
  • Organizer: 第73回日本血液学会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-14
• [Presentation] 多発性骨髄腫細胞におけるmicroRNAおよびDNAメチル転移酵素発現とその関連 (2011)
  • Author(s): 服部光、半田寛、佐々木佳子、高橋範行、後藤奈美、ルブナ アブドラフセイン アルケビシ、松井直紀、佐藤あずさ、斉藤貴之、斉藤明夫、大崎洋平、横濱章彦、小磯博美、三井健揮、塚本憲史、野島美久、村上博和
  • Organizer: 第73回日本血液学会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-14
• [Presentation] Common fragile site gene FHIT and WWOX expression are frequently altered in multiple myeloma (2011)
  • Author(s): 佐々木佳子、半田寛、松井直紀、高橋範行、服部光、後藤奈美、斉藤貴之、斉藤明夫、大崎洋平、松本守生、澤村守夫、横濱章彦、小磯博美、三井健揮、塚本憲史、野島美久、村上博和
  • Organizer: 第73回日本血液学会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-14
• [Presentation] 急性骨髄性白血病(AML)の染色体異常における遺伝子発現およびDNAメチル化の検討 (2011)
  • Author(s): 松井直紀、半田寛、佐々木佳子、高橋範行、後藤奈美、森山紀彦、高荷智紀、斉藤貴之、小河原はつ江、村上博和
  • Organizer: 第12回日本検査血液学会
  • Place of Presentation: 倉敷
  • Year and Date: 2011-07-17
• [Presentation] Th1/Th2比測定法における2法の比較-細胞内サイトカイン染色法とケモカインレセプター染色法について (2011)
  • Author(s): 井出規文、新井勝哉、牛木和美、佐藤友香、半田寛、小河原はつ江、村上博和
  • Organizer: 第12回日本検査血液学会
  • Place of Presentation: 倉敷
  • Year and Date: 2011-07-17
• [Presentation] Helicobacter Pylori感染患者におけるリンパ球サブセットの分析 (2011)
  • Author(s): 佐藤友香、小河原はつ江、井出規文、新井勝哉、牛木和美、静怜子、早川昌基、半田寛、村上博和
  • Organizer: 第12回日本検査血液学会
  • Place of Presentation: 倉敷
  • Year and Date: 2011-07-17
• [Presentation] 多発性骨髄腫における塩基除去修復遺伝子OGG1の検討 (2011)
  • Author(s): 牛江千明、森山紀彦、高荷智紀、高橋範行、佐々木佳子、服部光、斉藤貴之、小河原はつ江、村上博和
  • Organizer: 第12回日本検査血液学会
  • Place of Presentation: 倉敷
  • Year and Date: 2011-07-17
• [Presentation] 多発性骨髄腫におけるWWOX・FHITのメチル化と発現の検討 (2011)
  • Author(s): 佐々木佳子、半田寛、松井直紀、高橋範行、後藤奈美、森山紀彦、高荷智紀、斉藤貴之、小河原はつ江、村上博和
  • Organizer: 第12回日本検査血液学会
  • Place of Presentation: 倉敷
  • Year and Date: 2011-07-17
• [Presentation] 多発性骨髄腫細胞に対するCelastrolの抗腫瘍効果 (2011)
  • Author(s): 高橋範行、半田寛、松井直紀、服部光、佐々木佳子、森山紀彦、高荷智紀、斉藤貴之、小河原はつ江、村上博和
  • Organizer: 第12回日本検査血液学会
  • Place of Presentation: 倉敷
  • Year and Date: 2011-07-17
• [Presentation] Common fragile site gene FHIT (Fragile Histidine Triad Gene) and WWOX (WW domain containing oxidoreductase) expression are frequently altered in multiple myeloma (2011)
  • Author(s): Hand H, Sakaki Y, Matsui N, Hattori H, Takahashi N, Sato A, Saitoh T, Saitoh A, Osaki Y, Matsumoto M, Sawamura M, Koiso H, Mitsui T, Yokohama A, Tsukamoto N, Nojima Y, Murakami H
  • Organizer: 13^<th> International Myeloma Workshop
  • Place of Presentation: パリ
  • Year and Date: 2011-05-03
• [Presentation] Relation of IL-18 polymorphism to the susceptibility and clinical feature of multiple myeloma in Japanese patients (2011)
  • Author(s): Saitoh T, Moriyama N, Takani T, Hoshino T, Mitsui T, Koiso H, Yokohama A, Hand H, Tsukamoto N, Ogawara H, Sawamura M, Nojima Y, Murakami H
  • Organizer: 13^<th> International Myeloma Workshop
  • Place of Presentation: パリ
  • Year and Date: 2011-05-03
• [Presentation] 骨髄不全症での多項目自動血球分析装置XE-5000の末梢血球解析パラメーターとフローサイトメトリーによる骨髄造血細胞解析の検討 (2011)
  • Author(s): 井上まどか、神山知沙子、村上博和, 他
  • Organizer: 第12回日本検査血液学会
  • Place of Presentation: 倉敷
• [Presentation] Association of interleukin-18 gene polymorphism with severity of chronic immunethrombocytopenia (ITP). (2010)
  • Author(s): Saitoh T, Moriyama N, Takani T, Mitsui T, Hoshino T, Koiso H, Yokohama A, Handa H, Karasawa M, Ogawara H, Tsukamoto N, Murakami H.
  • Organizer: 第52回アメリカ血液学会
  • Place of Presentation: Orlalld, U.S.A.
  • Year and Date: 2010-12-06
• [Presentation] Significant reduced circulation plasmacytoid dendritic cells in patients with primary and Helicobacter pyroli-asociated immune thrombocytopenia. (2010)
  • Author(s): Saito A, Yokohama A, Osaki Y, Ogawa Y, Mitsui T, Uchiumi H, Saitoh T, Handa H, Sawamura M, Karasawa M, Murakami H, Nojima Y, Tsukamoto N.
  • Organizer: 第52回アメリカ血液学会
  • Place of Presentation: Orland, U.S.Aa
  • Year and Date: 2010-12-05
• [Presentation] Interleukin-17F gene polymorphism in patients with chronic immune thrombocytopeic purpura. (2010)
  • Author(s): Saitoh T, Tsukamoto N, Kasamatsu T, Koiso H, Yokohama A, Handa H, Karasawa M, Ogawara H, Nojima Y, Murakami H.
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2010-09-26
• [Presentation] Subclinical improvement of cardiac function in patients with iron over load after chelating therapy. (2010)
  • Author(s): Yokohama A, Negishi K, Ogawa Y, Osaki Y, Saito A, Kobayashi N, Mitsui T, Koiso H, Uchiumi H, Saitoh T, Handa H, Tsukamoto N, Karasawa M, Murakami H, Nojima Y.
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2010-09-25
• [Presentation] Pneumocystis jirovici pneumonia in patients with Hodgkin lymphoma. (2010)
  • Author(s): Koiso H, Saitoh T, Hoshino T, Mitsui T, Yokohama A, Uchiumi H, Handa H, Karasawa M, Murakami H, Nojima Y, Tsukamoto N.
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2010-09-25
• [Presentation] A woman with slowly progressive EBV associated lymphoproliferative disease had no immunosuppressant. (2010)
  • Author(s): Toyama K, Yuzuriha A, Mitsui I, Yokohama A, Uchiumi H, Saitoh T, Handa H, Tsukamoto N, Karasawa M, Murakami H, Nojima Y.
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2010-09-25
• [Presentation] High frequency of ralpase with granuloctic sarcoma in AML patients after allogeneic transplantation. (2010)
  • Author(s): Shimizu H, Saitoh T, Osaki Y, Hoshino T, Hatsumi N, Takada S, Yokohama A, Handa H, Jimbo T, Sakura T, Tsukamoto N, Murakami H.
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2010-09-24
• [Presentation] Relationship between circulation dendritic cells and T cell differentiation in patients with ITP. (2010)
  • Author(s): Saito A, Yokohama A, Osaki Y, Ogawa Y, Mitsui T, Hashimoto Y, Koiso H, Saitoh T, UchiUmi H, Handa H, Sawamura M, Kaiasawa M, Murakami H, Nojima Y, Tsukamoto N.
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2010-09-24
• [Presentation] Description of two cases of CD4+/CD56+ blastic plasmacytoid dendritic cell neoplasm (BPDC). (2010)
  • Author(s): Kobayashi N, Handa H, Mitsui T, Hayashi T, Mihara M, Ogawa Y, Uchiumi H, Yokohama A, Saitoh T, Yuzuriha A, Thyama K, Koiso H, Hoshino T, Tsukamoto N, Karasawa M, Murakami H, Nojima Y.
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2010-09-24
• [Presentation] 特発性血小板減少性紫斑病におけるIL-17Fの多型解析 (2010)
  • Author(s): 森山紀彦、斉藤貴之、高荷智紀、後藤奈美、佐々木佳子、松井直紀、佐藤友香、半田寛、小河原はつ江、村上博和
  • Organizer: 第11回日本検査血液学会
  • Place of Presentation: 東京ビックサイト、東京
  • Year and Date: 2010-07-25
• [Presentation] 悪性貧血における制御性T細胞測定の臨床的意義 (2010)
  • Author(s): 井出規文、新井勝哉、牛木和美、松井直紀、佐藤友香、早川昌基、静怜子、半田寛、小河原はっ江、村上博和
  • Organizer: 第11回日本検査血液学会
  • Place of Presentation: 東京ビックサイト、東京
  • Year and Date: 2010-07-24
• [Presentation] Human telomerase reverse transcriptase expression detected by flow cytometry inCD34 positive progenitor fraction in myelodysplastic syndrome and acute myeloid leukemia. (2010)
  • Author(s): Handa H, Murakami H, Matsushima T, Nishimoto N, Inoue M, Saitoh T, Yokohama A, Koiso H, Mitsui T, Tsukamoto N, Ogawara H, Karasawa M, Nojima Y.
  • Organizer: 第15回ヨーロッパ血液学会
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-06-11
• [Presentation] Human telomerase reverse transcriptase expression (HTERT) detected by flow cytometry in CD34 positive progenitor fraction in myelodysplastic syndrome and acute myeloid leukemia (2010)
  • Author(s): Handa H, Murakami H, et al
  • Organizer: 15^<th> Congress of the European Hematology Association
  • Place of Presentation: Barcelona
• [Book] 7.多発性骨髄腫、3.若年者多発性骨髄腫の治療.白血病リンパ腫骨髄腫 今日の診断と治療第4版(木崎昌弘編) (2011)
  • Author(s): 村上博和、斉藤貴之
  • Total Pages: 544
  • Publisher: 中外医学社
• [Book] 血液疾患における分子標的治療 ドラッグラグ解消に向けて (2010)
  • Author(s): 斉藤貴之、塚本憲史、村上博和
  • Total Pages: 350
  • Publisher: 医薬ジャーナル
• [Book] 造血貴腫瘍治療 2版 これは困ったぞ、どうしよう (2010)
  • Author(s): 半田寛、村上博和
  • Total Pages: 361
  • Publisher: 中外医学社
• [Book] 看護学大事典第2版 (2010)
  • Author(s): 村上博和
  • Total Pages: 3042
  • Publisher: 医学書院
• [Book] 造血器腫瘍取扱い規約 第4部多発性骨髄腫 (2010)
  • Author(s): 村上博和
  • Total Pages: 265
  • Publisher: 金原出版
• [Book] IMiDsの基礎と臨床 (2010)
  • Author(s): 村上博和、半田寛、斉藤貴之
  • Total Pages: 159
  • Publisher: 医薬ジャーナル