| Project/Area Number |
22590515
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Takayuki 群馬大学, 大学院・保健学研究科, 准教授 (80375542)
HANDA Hiroshi 群馬大学, 医学部, 講師 (90282409)
小河原 はつ江 群馬大学, 大学院・保健学研究科, 教授 (60134293)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 骨髄異形成症候群 / Toll-like receptor / apoptosis / 白血病 / myelodysplastic syndrome / RCMD / RAEB |
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| Research Abstract |
Myelodysplastic syndrome (MDS) is a clonal disease, characterized by ineffective hematopoiesis due to apoptosis of blood cells, progression to acute leukemia, and high frequency of autoimmune disease complications. Toll-like receptors (TLR) is reported to be involved in apoptosis, tumor immunity, and autoimmune disease. According to these, it is suspected that TLRs are associated with the pathogenesis of MDS. Twenty-one patients with MDS are included in this study. TLRs may be associated with the apoptosis of blood cells in high-risk MDS patients; however not be involved in the progression of MDS to leukemia.
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