| Project/Area Number |
22590516
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ALEXANDER LEZHAVA 独立行政法人理化学研究所, 上級研究員 (40443048)
USUI KENZGO 独立行政法人理化学研究所, 研究員 (10525372)
SUNAGA NORIAKI 群馬大学, 大学院・医学系研究科, 助教 (70400778)
TANAKA KAZUMI 群馬大学, 医学部, 医員 (30526843)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 肺癌 / 一塩基多型 / SNP / SmartAmp 法 / 喫煙 / MDM2 SNP309 / 発がん / SmartAmp法 / Smart Amplification Process法 / 禁煙外来 / MDM2 / Smart Amplification Process |
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| Research Abstract |
MDM2 is known as an oncoprotein that binds to p53 protein and inactivates the tumor suppressor activity of p53. Genetic polymorphisms in the MDM2 gene are suggested to be a tumor susceptibility marker and a prognostic factor for cancer. In this study, we have developed a new SNP detection method applied Smart Amplification Process (SmartAmp) method to detect the SNP c.309T>G in the MDM2 gene and conducted a large-scale case-controlled study. We found that there were no significant associations between MDM2 SNP309 genotypes and lung cancer risk. Subgroup analysis of smoking related lung cancer indicated that G/G genotype of SNP309 may be associated with lung cancer carcinogenesis.
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