Application of rapid gene analyzing method for susceptibility to cancer
| Project/Area Number |
22590516
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ALEXANDER LEZHAVA 独立行政法人理化学研究所, 上級研究員 (40443048)
USUI KENZGO 独立行政法人理化学研究所, 研究員 (10525372)
SUNAGA NORIAKI 群馬大学, 大学院・医学系研究科, 助教 (70400778)
TANAKA KAZUMI 群馬大学, 医学部, 医員 (30526843)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 肺癌 / 一塩基多型 / SNP / SmartAmp 法 / 喫煙 / MDM2 SNP309 / 発がん / SmartAmp法 / Smart Amplification Process法 / 禁煙外来 / MDM2 / Smart Amplification Process |
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| Research Abstract |
MDM2 is known as an oncoprotein that binds to p53 protein and inactivates the tumor suppressor activity of p53. Genetic polymorphisms in the MDM2 gene are suggested to be a tumor susceptibility marker and a prognostic factor for cancer. In this study, we have developed a new SNP detection method applied Smart Amplification Process (SmartAmp) method to detect the SNP c.309T>G in the MDM2 gene and conducted a large-scale case-controlled study. We found that there were no significant associations between MDM2 SNP309 genotypes and lung cancer risk. Subgroup analysis of smoking related lung cancer indicated that G/G genotype of SNP309 may be associated with lung cancer carcinogenesis.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Rapid Detection of SNP (c.309T>G) in the MDM2 Gene by the Duplex SmartAmp Method2013
Author(s)
Hanami, Yuki Kawai, Kengo Usui, Yasuko Okano, Seiichi Kakegawa, Hiroomi Ogawa, Yohei Miyamae, Yohei Miyagi, Haruhiko Nakayama, Toshihisa Ishikawa, Yoshihide Hayashizaki, Izumi Takeyoshi
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Journal Title
PLOS ONE
Volume: 8(4)
Issue: 4
Pages: 60151-60151
DOI
Related Report
Peer Reviewed
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