| Project/Area Number |
22590517
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUJITA Masaki 慶應義塾大学, 医学部, 教授 (00211524)
OKAJIMA Fumikazu 群馬大学, 生体調節研究所, 教授 (30142748)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | スフィンゴシン 1-リン酸 / ポックリ病 / レムナント / 心臓性突然死 / スフィンゴシン1-リン酸 / リポタンパク二次元マップ / apoM / apoA-I / スフィンゴシン1-リン酸(S-1-P) / レムナントリポ蛋白質 / 2次元電気泳動マップ / S1P受容体 |
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| Research Abstract |
We have proposed that triglyceride-rich lipoprotein remnants are associated with the risk of sudden coronary death in younger cases without coronary atherosclerosis. However, it remains unclear how remnants are involved in coronary sudden death. In the present study, we tried to relate sphingosine1-phosphate (S1P), which is concentrated in lipoproteins, and apolipoprotein M, an S1P binding apolipoprotein, to sudden death. Our new assay method to detect S1P allowed to measure a low concentration of S1P in serum; however, there are any significant difference in S1P levels between normal and sudden death patients. We are now focusing on the difference in two dimensionalelectrophoresis pattern measured by anti-apoA-I and anti-apoM antidodies.
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