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Medical examinations for obesity and hyperlipidemia with a focus on pediatric metabolic syndrome, and abnormalities of plasma lipoprotein

Research Project

Project/Area Number 22590525
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionBukkyo University (2011-2013)
Osaka University (2010)

Principal Investigator

YAMAMURA Taku  佛教大学, 保健医療技術学部, 教授 (20132938)

Co-Investigator(Renkei-kenkyūsha) ISHIGAMI Masato  大阪大学, 大学院医学系研究科, 准教授 (10379266)
Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords生活習慣病 / リポ蛋白 / メタボリックシンドローム / 動脈硬化 / 肥満 / 血清脂質 / 脂質異常症 / 小児 / 高脂血症 / やせ / コレステロール / トリグリセライド / トリグリセリド / レムナントリポ蛋白
Research Abstract

Medical examinations of childhood obesity and dyslipidemia have been conducted as a preventive measure against lifestyle-related diseases in school students in a region in Nara Prefecture. We comparatively evaluated an initial set of data obtained during 3 fiscal years from 1980 (subjects: 1,365 elementary and junior high school students; males and females) and a recent set of data obtained during 3 fiscal years from 2012 to 2014 (subjects: 995 students). There was no marked difference in the serum lipid level between the two groups of students. Gender- and grade-based analyses indicated that the prevalence of childhood obesity increased in male elementary school students. On the other hand, the prevalence of being thin also increased. In both male and female junior high school students, the prevalence of childhood obesity showed a decreasing trend, presumably reflecting their growing interest in personal appearance.

Report

(5 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (21 results)

All 2014 2013 2012 2011 2010

All Journal Article (10 results) (of which Peer Reviewed: 6 results) Presentation (11 results)

  • [Journal Article] アポE異常の発見2014

    • Author(s)
      山村卓
    • Journal Title

      臨床検査

      Volume: 58(2) Pages: 261-270

    • Related Report
      2013 Final Research Report
  • [Journal Article] アポE異常の発見2014

    • Author(s)
      山村 卓
    • Journal Title

      臨床検査

      Volume: 58 Pages: 261-270

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Remnant lipoprotein-cholesterol is a predictive biomarker for large artery atherosclerosis in apparently healthy women : usefulness as a parameter for annual health examinations2011

    • Author(s)
      Taguchi M, Ishigami M, Nishida M, Moriyama T, Yamashita S, Yamamura T
    • Journal Title

      Ann Clin Biochem

      Volume: 48(Pt 4) Issue: 4 Pages: 332-337

    • DOI

      10.1258/acb.2011.010244

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel apolipoprotein E mutation, ApoE Osaka (Arg158 Pro), in a dyslipidemic patient with lipoprotein glomerulo- pathy2011

    • Author(s)
      Mitani A, Ishigami M, Watase K, Minakata T, Yamamura T
    • Journal Title

      J Atheroscler Thromb

      Volume: 18(6) Pages: 531-535

    • NAID

      130004444517

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Novel Apolipoprotein E Mutation, apoE Osaka (Arg158 Pro), in a Dyslipidemic Patient with Lipoprotein Glomerulopathy2011

    • Author(s)
      Mitani, A
    • Journal Title

      J Atheroscler Thromb

      Volume: 18 Pages: 531-535

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] marker for large artery atherosclerosis in apparently healthy women : usef2011

    • Author(s)
      Taguchi M
    • Journal Title

      Ann Clin Biochem

      Volume: 48 Pages: 332-337

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Novel Apolipoprotein E Mutation, apoE Osaka (Arg158 Pro), in a Dyslipidemic Patient with Lipoprotein Glomerulopathy2011

    • Author(s)
      Asuka Mitani
    • Journal Title

      J Atheroscler Thromb

      Volume: 18

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of adolescent hyperlipoproteinemia with xanthoma and acute pancreatitis, associated with decreased activities of lipoprotein lipase and hepatic triglyceride lipase2010

    • Author(s)
      Fujita K, Maeda N, Kozawa J, Murano K, Okita K, Iwahashi H, Kihara S, Ishigami M, Omura M, Nakamura T, Shirai K, Yamamura T, Funahashi T, Shimomura I
    • Journal Title

      Intern Med

      Volume: 49(22) Pages: 2467-2472

    • NAID

      130000413378

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] レムナントリポ蛋白(RLP-C, RemL-C)2010

    • Author(s)
      山村卓
    • Journal Title

      Medical Technology

      Volume: 38(13) Pages: 1341-1346

    • Related Report
      2013 Final Research Report 2010 Annual Research Report
  • [Journal Article] レムナント代謝研究の最前線2010

    • Author(s)
      山村卓
    • Journal Title

      臨床病理

      Volume: 58(6) Pages: 613-621

    • NAID

      10027751698

    • Related Report
      2013 Final Research Report 2010 Annual Research Report
  • [Presentation] 小中学生における生活習慣病健診--肥満度と血清脂質値の40年間の推移--2013

    • Author(s)
      山村卓、鵜山光仁、山本章
    • Organizer
      第53回日本臨床化学会年次学術集会
    • Place of Presentation
      徳島
    • Year and Date
      2013-09-01
    • Related Report
      2013 Final Research Report
  • [Presentation] 小中学生における生活習慣病健診 --肥満度と血清脂質値の40年間の推移--2013

    • Author(s)
      山村 卓、鵜山 光仁、山本 章
    • Organizer
      第53回日本臨床化学会年次学術集会
    • Place of Presentation
      徳島市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 小中学生における小児生活習慣病健診2012

    • Author(s)
      山村卓、石神眞人、井上昌典、鵜山光仁、山本章
    • Organizer
      第34回日本臨床栄養学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-10-07
    • Related Report
      2013 Final Research Report
  • [Presentation] 小中学生における小児生活習慣病健診2012

    • Author(s)
      山村 卓
    • Organizer
      第34回日本臨床栄養学会総会
    • Place of Presentation
      東京都千代田区
    • Related Report
      2012 Annual Research Report
  • [Presentation] 小中学生における肥満と脂質異常症2011

    • Author(s)
      山村卓、石神眞人、井上昌典、鵜山光仁、山本章
    • Organizer
      第51回日本臨床化学会年次学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2011-08-27
    • Related Report
      2013 Final Research Report
  • [Presentation] 小中学生における肥満と脂質異常症2011

    • Author(s)
      山村卓
    • Organizer
      第43回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      札幌医科大学(札幌)
    • Year and Date
      2011-08-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] シンポジウム3「レムナントリホ?蛋白分析update」レムナント研究の歴史と今後の展望2011

    • Author(s)
      山村卓
    • Organizer
      第21回生物試料分析科学会年次学術集会
    • Place of Presentation
      松山
    • Year and Date
      2011-02-20
    • Related Report
      2013 Final Research Report
  • [Presentation] シンポジウム3「レムナントリポ蛋白分析update」レムナント研究の歴史と今後の展望2011

    • Author(s)
      山村卓
    • Organizer
      第21回生物試料分析科学会年次学術集会
    • Place of Presentation
      愛媛大学(松山市)
    • Year and Date
      2011-02-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] レムナントリポ蛋白コレステロール(RemL-C)の動脈硬化危険因子としての意義に関する研究2010

    • Author(s)
      石神眞人、山村卓
    • Organizer
      第50回日本臨床化学会年次学術集会
    • Place of Presentation
      甲府
    • Year and Date
      2010-09-24
    • Related Report
      2013 Final Research Report
  • [Presentation] 年次健康診断におけるレムナントリポ蛋白コレステロール2010

    • Author(s)
      石神眞人、山村卓
    • Organizer
      第57回日本臨床検査医学会学術集会
    • Place of Presentation
      岐阜
    • Year and Date
      2010-09-10
    • Related Report
      2013 Final Research Report
  • [Presentation] In vitro demonstration of plaque stabilizing effects of apo- lipoprotein E via inhibition of oxidized low-density lipoprotein-induced mac- rophage activation2010

    • Author(s)
      Ishigami M, Kitamura M, Yamashita S, Yamamura T
    • Organizer
      第42回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      岐阜
    • Year and Date
      2010-07-16
    • Related Report
      2013 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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