| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
The aim of this study is to find a biomarker for atherosclerosis or its comprehensive risk factors from the point of view of DNA damage/repair. The experiments using atherosclerotic mice lacking DNA damage response revealed that abnormality in DNA damage-repair accumulates DNA damage and accelerates atherosclerosis. According to the results, we established the method to quantify DNA damage, especially double strand breaks in human mononuclear cells. We showed that this method precisely detect one of the atherosclerotic risk factors, smoking. It isimportant for preventive medicine to further verify whether this method can estimateother risk factors comprehensively.
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