ESTABLISH THE INDIVIDUALIZED TREATMENT ON LUNG ADENOCARCINOMA USINGTHE EGFR GENE MUTATION ANALYSIS.
| Project/Area Number |
22590531
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKATOMI Katsumi 長崎大学, 長崎大学病院, 助教 (90457531)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 遺伝子検査学 / 非小細胞肺癌 / 上皮増殖因子受容体 / 遺伝子変異多型 / オーダーメイド治療 |
|---|
| Research Abstract |
Intra-tumor heterogeneity of EGFR mutations in patients with mixed-type lung adenocarcinoma was analyzed according to the distribution of histological subtypes. Intra-tumor heterogeneity of EGFR mutations was detected in 9 of 38 tumors, and there was a significant correlation between heterogeneity of EGFR mutations and smoking history (P<0.043).
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Report
(4 results)
Research Products
(26 results)
